Results 81 to 90 of about 228,208 (202)
Histone Deacetylase: A Regulator of Transcription [PDF]
Science, 1996 Histones are DNA binding proteins that bind without regard to the sequence of the DNA and help determine the three-dimensional organization of the chromatin into chromosomes. A paper in this week's issue (Taunton et al ., p.
openaire +3 more sources
The role of HDAC2 in chromatin remodelling and response to chemotherapy in ovarian cancer [PDF]
, 2015 This study was supported by financial support from the University of Edinburgh/China Scholarship Council joint Scholarship Scheme. We are also grateful to support from the Scottish Funding Council.Chromatin undergoes structural changes in response to ...
Mullen, Peter +8 more
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Histone Deacetylase Inhibitors: Novel advances in Cancer Therapy
, 2018 Nowadays, it became evident that the onset of cancer and its progression may not occur only due to genetic mutations but also because of changes in the patterns of epigenetic modifications.
Quach, Khong Tri
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Histone deacetylase inhibitors and methods of use [PDF]
, 2023 Disclosed are methods of treating an acute myeloid leukemia patient of cytogenetic subgroups having increased histone deacetylase recruitment by administering a histone deacetylase inhibitor to the ...
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Data in Brief, 2018 This data article contains descriptive and experimental data on ion channel gene expressions following the histone deacetylase (HDAC) inhibitor treatment of neural induced human adipose tissue-derived mesenchymal stem cells (NI-hADSCs).
Sujeong Jang, Han-Seong Jeong
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Histone methylation by PRC2 is inhibited by active chromatin marks [PDF]
, 2013 Chromatin modifiers serve as regulatory switches that control the cell cycle, maintain pluripotency and drive differentiation and development. Positive feedback mechanisms help to pass on transcriptional information from one generation of cells to the ...
Schmitges, Frank W.
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Role of histone deacetylase inhibitors in non-neoplastic diseases
HeliyonBackground: Epigenetic dysregulation has been implicated in the development and progression of a variety of human diseases, but epigenetic changes are reversible, and epigenetic enzymes and regulatory proteins can be targeted using small molecules ...
Chunxiao Zhou +7 more
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Lysine acetylome profiling uncovers novel histone deacetylase substrate proteins in Arabidopsis
Molecular Systems Biology, 2017 Histone deacetylases have central functions in regulating stress defenses and development in plants. However, the knowledge about the deacetylase functions is largely limited to histones, although these enzymes were found in diverse subcellular ...
Markus Hartl +15 more
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MiR-376a and Histone Deacetylation 9 Form A Regulatory Circuitry in Hepatocellular Carcinoma
Cellular Physiology and Biochemistry, 2015 Background/Aims: Our previous study has demonstrated that down-regulation of miR-376a might contribute to the development of hepatocellular carcinoma (HCC), but the mechanism underlying this down-regulation remains obscure.
Yongxia Zheng +8 more
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NoRC, a novel chromatin remodeling complex involved in ribosomal RNA gene silencing [PDF]
, 2004 Regulation of gene expression takes place in the nucleus in a highly structured and condensed nucleoprotein environment, called chromatin (Felsenfeld and Groudine, 2003; Khorasanizadeh, 2004; Vaquero et al., 2003).
Strohner, Ralf
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