Results 81 to 90 of about 123,729 (215)
Nitric oxide induces chromatin remodelling in the developing central nervous system [PDF]
, 2009 The development of the nervous system is a complex task that involves precise connections between billions of neurons. This is achieved, at least in part, by the overproduction of neurons and the survival of a select few that compete for limited ...
Nott, A, Nott, A.
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Data in Brief, 2018 This data article contains descriptive and experimental data on ion channel gene expressions following the histone deacetylase (HDAC) inhibitor treatment of neural induced human adipose tissue-derived mesenchymal stem cells (NI-hADSCs).
Sujeong Jang, Han-Seong Jeong
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Histone deacetylase inhibitors and methods of use [PDF]
, 2023 Disclosed are methods of treating an acute myeloid leukemia patient of cytogenetic subgroups having increased histone deacetylase recruitment by administering a histone deacetylase inhibitor to the ...
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Butyrate Histone Deacetylase Inhibitors
BioResearch Open Access, 2012 In addition to being a part of the metabolic fatty acid fuel cycle, butyrate is also capable of inducing growth arrest in a variety of normal cell types and senescence-like phenotypes in gynecological cancer cells, inhibiting DNA synthesis and cell growth in colonic tumor cell lines, suppressing hTERT mRNA expression and telomerase activity in human ...
Steliou, Kosta +4 more
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HDAC3 (histone deacetylase 3) [PDF]
, 2008 Review on HDAC3 (histone deacetylase 3), with data on DNA, on the protein encoded, and where the gene is ...
Escaffit, F
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Role of histone deacetylase inhibitors in non-neoplastic diseases
HeliyonBackground: Epigenetic dysregulation has been implicated in the development and progression of a variety of human diseases, but epigenetic changes are reversible, and epigenetic enzymes and regulatory proteins can be targeted using small molecules ...
Chunxiao Zhou +7 more
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Lysine acetylome profiling uncovers novel histone deacetylase substrate proteins in Arabidopsis
Molecular Systems Biology, 2017 Histone deacetylases have central functions in regulating stress defenses and development in plants. However, the knowledge about the deacetylase functions is largely limited to histones, although these enzymes were found in diverse subcellular ...
Markus Hartl +15 more
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Genome Biology, 2019 Histone acetylation plays a central role in gene regulation and is sensitive to the levels of metabolic intermediates. However, predicting the impact of metabolic alterations on acetylation in pathological conditions is a significant challenge.
Fangzhou Shen +4 more
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Histone deacetylases in viral infections
Clinical Epigenetics, 2010 Abstract Chromatin remodeling and gene expression are regulated by histone deacetylases (HDACs) that condense the chromatin structure by deacetylating histones. HDACs comprise a group of enzymes that are responsible for the regulation of both cellular and viral genes at the transcriptional level.
Herbein, Georges, Wendling, Daniel
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, 2008 We investigated the cytotoxicity and biology of the novel broad-spectrum hydroxamic acid-based histone deacetylase inhibitor (HDACi), PCI-24781. PCI-24781 was studied alone and combined with bortezomib in Hodgkin lymphoma (L428) and non-Hodgkin's ...
Kevin David +9 more
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