Results 91 to 100 of about 228,208 (202)

Genome-scale network model of metabolism and histone acetylation reveals metabolic dependencies of histone deacetylase inhibitors

Genome Biology, 2019
Histone acetylation plays a central role in gene regulation and is sensitive to the levels of metabolic intermediates. However, predicting the impact of metabolic alterations on acetylation in pathological conditions is a significant challenge.
Fangzhou Shen, Luigi Boccuto, Rini Pauly, Sujata Srikanth, Sriram Chandrasekaran   +4 more
doaj   +1 more source

HDAC3 (histone deacetylase 3) [PDF]

, 2008
Review on HDAC3 (histone deacetylase 3), with data on DNA, on the protein encoded, and where the gene is ...
Escaffit, F
core   +1 more source

The Potential Role of Epigenetic Drugs in the Treatment of Anxiety Disorders

Neuropsychiatric Disease and Treatment, 2020
Jacob Peedicayil Department of Pharmacology & Clinical Pharmacology, Christian Medical College, Vellore, IndiaCorrespondence: Jacob PeedicayilDepartment of Pharmacology & Clinical Pharmacology, Christian Medical College, Vellore, IndiaTel/Fax +91-
Peedicayil J
doaj  

Use of Histone Deacetylase Inhibitors (HDI): Novel Advances in Cancer Treatment

, 2020
Histone deacetylase inhibitors are powerful epigenetic modifiers, altering gene expression and on a larger aspect, the fate of individual cells. The Food and Drugs Administration has approved the use of four new HDIs, bringing about a revolutionary dawn ...
Savani, Vandan
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Untersuchungen zur Regulation der 5-Lipoxygenase-Gen-Expression durch DNA-Methylierung und Histon-Deacetylierung/Acetylierung [PDF]

, 2007
5-LO is the key enzyme in the biosynthesis of proinflammatory leukotrienes, converting arachidonic acid to 5-HPETE, and in a second step 5-HPETE to leukotriene A4. Although the 5-LO promoter possesses characteristics of so called housekeeping genes, such
Schnur, Nicole
core  

HDACiDB: a database for histone deacetylase inhibitors

, 2015
Kasi Murugan,1 Shanmugasamy Sangeetha,2 Shanmugasamy Ranjitha,2 Antony Vimala,2 Saleh Al-Sohaibani,1 Gopal Rameshkumar21Department of Botany and Microbiology, College of Science, King Saud University, Riyadh, Saudi Arabia; 2Bioinformatics Laboratory ...
Vimala A, Murugan K, Sangeetha S, Rameshkumar G, Ranjitha S, Al-Sohaibani S   +5 more
core  

Targeted intervention of tumor microenvironment with HDAC inhibitors and their combination therapy strategies

European Journal of Medical Research
Histone deacetylation represents a significant epigenetic mechanism that involves the removal of acetyl groups from histones, subsequently influencing gene transcription.
Wanli Zhang, Luqi Ge, Yiwen Zhang, Zhentao Zhang, Wen Zhang, Feifeng Song, Ping Huang, Tong Xu   +7 more
doaj   +1 more source

Advanced Progress of Histone Deacetylases in Rheumatic Diseases

Journal of Inflammation Research
Xue-Mei Liu,1,2,* Liu Yang,1,2,* Qi-Bin Yang1 1Department of Rheumatology and Immunology, Affiliated Hospital of North Sichuan Medical College, Nanchong, Sichuan Province, 637000, People’s Republic of China; 2Department of Clinical Medicine ...
Liu XM, Yang L, Yang QB
doaj  

Starch nanoparticles for delivery of the histone deacetylase inhibitor CG-1521 in breast cancer treatment

, 2019
Esma Alp,1–4 Fehmi Damkaci,2 Eylem Guven,1 Martin Tenniswood3,4 1Department of Nanotechnology and Nanomedicine, Hacettepe University, Beytepe, Ankara 06800, Turkey; 2Department of Chemistry, State University of New York at Oswego, Oswego, NY 13126,
Damkaci F, Tenniswood M, Guven E, Alp E
core  

Use of histone deacetylase inhibitors: Novel advances in cancer treatment

, 2020
Histone deacetylase inhibitors (HDACIs) are a reassuring group of anti-cancer drugs that alters the gene expression patterns of cancer cells through epigenetic modulation.
Dogantimur, Ozge
core