Results 111 to 120 of about 237,704 (293)

Epigenetic Silencing of CYYR1 Promotes Lung Adenocarcinoma Progression Through TRIM21‐Dependent Regulation of HMMR Stability

Advanced Science, EarlyView.
CYYR1 as an epigenetically dysregulated tumor‐suppressive factor that influences oncoprotein stability through TRIM21‐dependent HMMR regulation and reveals a potential therapeutic vulnerability in CYYR1‐deficient LUAD. The graphical illustration was created using FigDraw (www.figdraw.com).
Fengsheng Dai, Jingyi Tang, Huan Rong, Yu Wang, Xiangyi Zhou, Can Xu, Jianhua Wang, Lili Li, Yue Wu, Fei Deng, Dan Yang, Xiao Yang, Renyan Li, Yongzhong Wu, Dongxi Xiang, Tingxiu Xiang   +15 more
wiley   +1 more source

RIPK3 dampens mitochondrial bioenergetics and lipid droplet dynamics in metabolic liver disease

Hepatology, EarlyView., 2022
RIPK3 dampens mitochondrial bioenergetics and lipid droplet dynamics in metabolic liver disease. Abstract Background and Aims Receptor‐interacting protein kinase 3 (RIPK3) mediates NAFLD progression, but its metabolic function is unclear. Here, we aimed to investigate the role of RIPK3 in modulating mitochondria function, coupled with lipid droplet (LD)
Marta B. Afonso, Tawhidul Islam, Julie Magusto, Ricardo Amorim, Véronique Lenoir, Rui F. Simões, José Teixeira, Liana C. Silva, Dominique Wendum, Isabelle Jéru, Corinne Vigouroux, Rui E. Castro, Paulo J. Oliveira, Carina Prip‐Buus, Vlad Ratziu, Jérémie Gautheron, Cecília M. P. Rodrigues   +16 more
wiley   +1 more source

Role of histone deacetylase inhibitors in non-neoplastic diseases

Heliyon
Background: Epigenetic dysregulation has been implicated in the development and progression of a variety of human diseases, but epigenetic changes are reversible, and epigenetic enzymes and regulatory proteins can be targeted using small molecules ...
Chunxiao Zhou, Dengke Zhao, Chunyan Wu, Zhimin Wu, Wen Zhang, Shilv Chen, Xindong Zhao, Shaoling Wu   +7 more
doaj   +1 more source

Lysine acetylome profiling uncovers novel histone deacetylase substrate proteins in Arabidopsis

Molecular Systems Biology, 2017
Histone deacetylases have central functions in regulating stress defenses and development in plants. However, the knowledge about the deacetylase functions is largely limited to histones, although these enzymes were found in diverse subcellular ...
Markus Hartl, Magdalena Füßl, Paul J Boersema, Jan‐Oliver Jost, Katharina Kramer, Ahmet Bakirbas, Julia Sindlinger, Magdalena Plöchinger, Dario Leister, Glen Uhrig, Greg BG Moorhead, Jürgen Cox, Michael E Salvucci, Dirk Schwarzer, Matthias Mann, Iris Finkemeier   +15 more
doaj   +1 more source

MiR-376a and Histone Deacetylation 9 Form A Regulatory Circuitry in Hepatocellular Carcinoma

Cellular Physiology and Biochemistry, 2015
Background/Aims: Our previous study has demonstrated that down-regulation of miR-376a might contribute to the development of hepatocellular carcinoma (HCC), but the mechanism underlying this down-regulation remains obscure.
Yongxia Zheng, Huan Chen, Manxiang Yin, Xiaoqian Ye, Guiqian Chen, Xinmei Zhou, Lei Yin, Chengwen Zhang, Baoyue Ding   +8 more
doaj   +1 more source

ERα–PADI4–CXCL8 Axis Drives MDSC‐Mediated Immune Evasion in Anaplastic Thyroid Carcinoma

Advanced Science, EarlyView.
MAPK‐driven ligand‐independent ERα activation drives PADI4 transcription and translation. This enzyme then modifies CXCL8 chemokines through citrullination, generating a potent chemoattractant gradient specifically for myeloid‐derived suppressor cells.
Dongdong Zhang, Ying Cai, Junbin Zhang, Jianyong Zhang, Ran Jing, Ming Cai   +5 more
wiley   +1 more source

Molecular Landscapes of Tumor Dormancy in Gynecologic Malignancies: From Survival Mechanisms to Precision Interception

Advanced Science, EarlyView.
This Review outlines the biological framework of entry, maintenance, and awakening in dormant minimal residual disease across gynecologic cancers. By mapping critical biological dependencies—from metabolic plasticity to microenvironment interactions—it evaluates novel interception concepts and presents a translational framework combining single‐cell ...
Shih‐Hsuan Cheng, Ren‐Wang Peng, Chang‐Cheng Wu, Chi‐Wen Luo, Emmanuel Naveen Raj, Zhi‐Hong Wen, Tzu‐Hung Hsiao, Chia‐Jung Li   +7 more
wiley   +1 more source

The Potential Role of Epigenetic Drugs in the Treatment of Anxiety Disorders

Neuropsychiatric Disease and Treatment, 2020
Jacob Peedicayil Department of Pharmacology & Clinical Pharmacology, Christian Medical College, Vellore, IndiaCorrespondence: Jacob PeedicayilDepartment of Pharmacology & Clinical Pharmacology, Christian Medical College, Vellore, IndiaTel/Fax +91-
Peedicayil J
doaj  

Supplementary Data from Histone Deacetylase 8 in Neuroblastoma Tumorigenesis

, 2009
Supplementary Data from Histone Deacetylase 8 in Neuroblastoma ...
Annette Kopp-Schneider (331828), Scott M. Ulrich (14973777), Matthias Fischer (76016), Ina Oehme (1463521), Olaf Witt (1463524), Diana Pickert (14973771), Frank Westermann (41848), Jan-Peter Linke (14973774), Andreas von Deimling (88694), Barbara Hero (3561296), Hedwig E. Deubzer (2822921), Dennis Wegener (8161593)   +11 more
core   +1 more source

ACAT1‐Mediated SP1‐K694 Lactylation Promotes M1 Macrophage Polarization via TREM1 Transcription in COPD

Advanced Science, EarlyView.
Upon cigarette smoke exposure(CSE), LDHA expression is increased in lung macrophages, promoting the conversion of pyruvate to lactate and elevating the lactylation level of SP1 at the K694 site. This, in turn, enhances SP1 enrichment at the TREM1 promoter, increases TREM1 expression, promoted M1 macrophage polarization, and triggers the secretion of ...
Ling Lin, Ping Zhang, Qing Song, Tao Li, Yuqin Zeng, Ping Chen   +5 more
wiley   +1 more source