Results 101 to 110 of about 123,729 (215)

Epigenetic dynamics of Helicobacter pylori-induced COX-2 activation

, 2009
Background and Aims: Cyclooxigenase (COX)-2 is over expressed in gastrointestinal neoplasia and Helicobacter pylori (H. pylori) infection is casually linked to gastric cancer. We undertook this study to investigate the mechanism mediating H.
Peluso, Silvia
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Starch nanoparticles for delivery of the histone deacetylase inhibitor CG-1521 in breast cancer treatment

, 2019
Esma Alp,1–4 Fehmi Damkaci,2 Eylem Guven,1 Martin Tenniswood3,4 1Department of Nanotechnology and Nanomedicine, Hacettepe University, Beytepe, Ankara 06800, Turkey; 2Department of Chemistry, State University of New York at Oswego, Oswego, NY 13126,
Damkaci F, Tenniswood M, Guven E, Alp E
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Advanced Progress of Histone Deacetylases in Rheumatic Diseases

Journal of Inflammation Research
Xue-Mei Liu,1,2,* Liu Yang,1,2,* Qi-Bin Yang1 1Department of Rheumatology and Immunology, Affiliated Hospital of North Sichuan Medical College, Nanchong, Sichuan Province, 637000, People’s Republic of China; 2Department of Clinical Medicine ...
Liu XM, Yang L, Yang QB
doaj  

Untersuchungen zur Regulation der 5-Lipoxygenase-Gen-Expression durch DNA-Methylierung und Histon-Deacetylierung/Acetylierung

, 2007
5-LO is the key enzyme in the biosynthesis of proinflammatory leukotrienes, converting arachidonic acid to 5-HPETE, and in a second step 5-HPETE to leukotriene A4. Although the 5-LO promoter possesses characteristics of so called housekeeping genes, such
Schnur, Nicole
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Pan-histone deacetylase inhibitor panobinostat sensitizes gastric cancer cells to anthracyclines via induction of CITED2

, 2012
Chemotherapy modestly prolongs survival of patients with advanced gastric cancer, but strategies are needed to increase its efficacy. Histone deacetylase (HDAC) inhibitors modify chromatin and can block cancer cell proliferation and promote ...
Herrmann, Ken, Zimmermann, Wolfgang, Hofheinz, Ralf, Friedrich, Teresa, Röcken, Christoph, Regel, Ivonne, Burgermeister, Elke, Ebert, Matthias P, Einwächter, Henrik, Merkl, Lisa, Schmid, Roland, Langer, Rupert   +11 more
core   +1 more source

Ets-2 repressor factor recruits histone deacetylase to silence human cytomegalovirus immediate-early gene expression in non-permissive cells

, 2005
Previous work from this laboratory has shown that expression of human cytomegalovirus (HCMV) immediate-early (IE) genes from the major immediate-early promoter (MIEP) is likely to be regulated by chromatin remodelling around the promoter affecting the ...
Bain, M., Mark Bain, Edward Wright, Linda Teague, John Sinclair, Wright, E., Jane Murphy, Teague, L., Murphy, J., Sinclair, J.   +9 more
core   +1 more source

Divergent Access to Histone Deacetylase Inhibitory Cyclopeptides via Late- Stage Cyclopropane Ring Cleavage Strategy. Short Synthesis of Chlamydocin

, 2019
We present a unified step-economical strategy to access histone deacetylase inhibitory peptides, based on late-stage installation of zinc-binding functionalities via the cleavage of the strained cyclopropane ring in the common pluripotent cyclopropanol ...
Dzmitry, Zubrytski, Nele, Konrad, Gabor Zoltan, Elek, Kaur, Koppel, Margus, Lopp, Dzmitry, Kananovich, Ivar, Järving   +6 more
core   +1 more source

The CBX7 protein, whose expression is decreased in human carcinomas, positively regulates E-cadherin expression by interacting with the HDAC2 protein.

, 2009
CBX7, chromobox homolog 7, is a chromobox family protein encoding a novel Polycomb protein, component of the Polycomb repressive complex 1 (PRC1). The Polycomb group (PcG) proteins are epigenetic transcriptional repressors involved in the control of ...
Bianco, Mimma
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Discovery and validation of SIRT2 inhibitors based on tenovin-6 : use of a 1H-NMR method to assess deacetylase activity

, 2012
The search for potent and selective sirtuin inhibitors continues as chemical tools of this type are of use in helping to assign the function of this interesting class of deacetylases.
Pirrie, L, Sonia Lain, Major, LL, Zubriene, Asta, Lebl, T, Matulis, Daumantas, Lisa Pirrie, Morkunaite, Vaida, Tomas Lebl, McCarthy, Anna R., Asta Zubrienė, Louise L. Major, Matulis, D, Lain, Sonia, Daumantas Matulis, Morkunaite, V, Nicholas J. Westwood, Vaida Morkūnaitė, Major, Louise L., Westwood, NJ, Anna R. McCarthy, McCarthy, AR, Zubriene, A, Lebl, Tomas, Lain, S, Westwood, Nicholas J., Pirrie, Lisa   +26 more
core   +1 more source

Design, synthesis, and antitumor evaluation of histone deacetylase inhibitors with L-phenylglycine scaffold

, 2015
Yingjie Zhang,1 Xiaoguang Li,1 Jinning Hou,1 Yongxue Huang,2 Wenfang Xu1 1Department of Medicinal Chemistry, School of Pharmacy, Shandong University, Ji’nan, 2Weifang Bochuang International Biological Medicinal Institute, Weifang, Shandong, People&
Li X, Hou J, Huang Y, Zhang Y, Xu W
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