Results 141 to 150 of about 776,666 (283)

The Use of Histone Deacetylase Inhibitors: Novel Advances in Cancer Treatment

This thesis explores the role of histone deacetylase inhibitors (HDACis) as promising epigenetic therapies in cancer treatment. HDACis modulate gene expression by inhibiting histone deacetylases, leading to the reactivation of tumor suppressor genes ...
Raad , Lara
core  

The association between neural crest‐derived glia and melanocyte lineages throughout development and disease

Developmental Dynamics, EarlyView.
Abstract Neural crest cells are a transient cell population that emerges from the dorsal neural tube during neurulation and migrates extensively throughout the embryo. Among their diverse derivatives, glial cells (such as Schwann and satellite ganglionic cells) and melanocytes represent two major lineages. In vitro studies suggested they share a common
Chaya Kalcheim
wiley   +1 more source

Systemic aging fuels heart failure: Molecular mechanisms and therapeutic avenues

ESC Heart Failure, Volume 12, Issue 2, Page 1059-1080, April 2025.
Abstract Systemic aging influences various physiological processes and contributes to structural and functional decline in cardiac tissue. These alterations include an increased incidence of left ventricular hypertrophy, a decline in left ventricular diastolic function, left atrial dilation, atrial fibrillation, myocardial fibrosis and cardiac ...
Zhuyubing Fang, Umar Raza, Jia Song, Junyan Lu, Shun Yao, Xiaohong Liu, Wei Zhang, Shujuan Li   +7 more
wiley   +1 more source

Histone deacetylase inhibitors enhance the amoebicidal activity of amphotericin B against Naegleria fowleri. [PDF]

Int J Parasitol Drugs Drug Resist
Lee HA, Jo HJ, Hong JY, Quan FS, Moon EK.   +4 more
europepmc   +1 more source

Gut microbiota‐related modulation of immune mechanisms in post‐infarction remodelling and heart failure

ESC Heart Failure, Volume 12, Issue 2, Page 942-954, April 2025.
Abstract The immune system has long been recognized as a key driver in the progression of heart failure (HF). However, clinical trials targeting immune effectors have consistently failed to improve patient outcome across different HF aetiologies. The activation of the immune system in HF is complex, involving a broad network of pro‐inflammatory and ...
Johann Roessler, Friederike Zimmermann, Bettina Heidecker, Ulf Landmesser, Arash Haghikia   +4 more
wiley   +1 more source

Design, Synthesis, and Antitumor Activities of Novel Coumarin-Based Histone Deacetylase Inhibitors. [PDF]

Biomolecules
Yan S, Chang J, Lei D, Lv X, Li Y, Zhuo Y, Jin L, Pan L.   +7 more
europepmc   +1 more source

Sustainable Iron Catalysis for Chemodivergent Oxidation of Lignin‐Based Vanillyl Alcohol: Selective Access to Vanillin and Vanillic Acid

European Journal of Organic Chemistry, EarlyView.
Green reaction media enable chemodivergent oxidation of vanillyl alcohol, selectively affording vanillin or its fully oxidized counterpart, vanillic acid. The use of an earth‐abundant, inexpensive, and nontoxic iron catalyst for the transformation of lignin‐derived alcohol to fine chemicals underscores the sustainability of the process. A low E‐factor (
Rasmiranjan Hota, Chinmaya Kumar Meher, Bidraha Bagh   +2 more
wiley   +1 more source

Current Research in Polypharmacology for Cancer Treatment Using Dual-Target Histone Deacetylase Inhibitors. [PDF]

Int J Mol Sci
Yudaev P, Aleksandrova Y, Neganova M.
europepmc   +1 more source

Synthesis of β‐ and γ‐Carbolinones Through a Fe(III)‐Mediated Radical 6‐Endo‐Trig Cyclization of Indole‐Based Ugi 4‐CR Adducts

European Journal of Organic Chemistry, EarlyView.
A practical strategy for synthesizing β‐ and γ‐carbolinones from indole‐based Ugi 4‐CR adducts through an intramolecular radical cyclization using Fe(III)–H species is presented. This approach enables the efficient synthesis of spiro‐carbolinones under mild reaction conditions and demonstrates the effectiveness of secondary radicals in both cyclization
María F. Olvera‐Granados, Luis A. Polindara‐García   +1 more
wiley   +1 more source

Zinc Affinity of Benzamide-Based Histone Deacetylase Inhibitors: A DFT Study. [PDF]

Molecules
Toshev N, Velichkov K, Uzunova Y, Cheshmedzhieva D, Dudev T.   +4 more
europepmc   +1 more source