Results 191 to 200 of about 98,638 (334)

In vivoBiological Activity of the Histone Deacetylase Inhibitor LAQ824 Is detectable with 3′-Deoxy-3′-[18F]Fluorothymidine Positron Emission Tomography [PDF]

, 2006
Julius Leyton, John P. Alao, Marco Da Costa, Alexandra Stavropoulou, John Latigo, Meg Perumal, Radhakrishna G. Pillai, Qimin He, Peter Atadja, Eric W.‐F. Lam, Paul Workman, David M. Vigushin, Eric O. Aboagye   +12 more
openalex   +1 more source

Data from The Histone Deacetylase Inhibitor MGCD0103 Induces Apoptosis in B-Cell Chronic Lymphocytic Leukemia Cells through a Mitochondria-Mediated Caspase Activation Cascade

, 2023
Victoria El‐Khoury, Etienne Moussay, Bassam Janji, Valérie Palissot, Nasséra Aouali, Nicolaas H. C. Brons, Kris Van Moer, Sandrine Pierson, Eric Van Dyck, Guy Berchem   +9 more
openalex   +1 more source

Non‐Histone Lactylation: A New Frontier in Cerebral Ischemia‐Reperfusion Injury

Med Research, EarlyView.
ABSTRACT Reperfusion therapy is the mainstay of treatment for ischemic stroke (IS) but frequently exacerbates secondary injury. Following cerebral ischemia and hypoxia, lactate accumulates markedly. Traditionally regarded as a metabolic byproduct, lactate has gained new significance with the discovery of protein lactylation. In addition to experimental
Minghui Tang, Yuying Mo, Zhishan Ling, Yuting Zeng, Qi Zhang, Shuqi Zheng, Shuyang Wen, Yupeng Xiao, Siying Long, Tingting Yang, Qianru Li, Wenjie Shi, Guozhi Huang, Qing Zeng   +13 more
wiley   +1 more source

Stage-Specific Expression of Histone Deacetylases in the Mouse Mandibular Condylar Cartilage. [PDF]

Cartilage
Yang C, Li H, Kong J, Wang M, Wang J, Guo X, Zhan Y.   +6 more
europepmc   +1 more source

Dynamic Structure-Based Pharmacophore Model Development: A New and Effective Addition in the Histone Deacetylase 8 (HDAC8) Inhibitor Discovery [PDF]

, 2011
Sundarapandian Thangapandian, Shalini John, Yuno Lee, Songmi Kim, Keun Woo Lee   +4 more
openalex   +1 more source

Vorinostat combined with osimertinib prompts transcription of active BIM isoform in cells which are homozygous for the BIM deletion polymorphism. from Histone Deacetylase 3 Inhibition Overcomes <i>BIM</i> Deletion Polymorphism–Mediated Osimertinib Resistance in <i>EGFR-</i>Mutant Lung Cancer

, 2023
Azusa Tanimoto, Shinji Takeuchi, Sachiko Arai, Koji Fukuda, Tadaaki Yamada, Xavier Roca, S. Tiong Ong, Seiji Yano   +7 more
openalex   +1 more source

Circadian Immunity and Vascular Inflammation in Cardiovascular Disease Chronotherapy Windows: Time for a Re‐Assessment

Med Research, EarlyView.
ABSTRACT Circadian rhythms orchestrate cardiovascular physiology by regulating immune and inflammatory pathways. Disruption of these rhythms profoundly alters vascular homeostasis, thereby promoting the onset and progression of cardiovascular diseases (CVD).
Tian Zhang, Ge Zhang, Tian‐Ding Liu, Tianshu Gu, Fengyi Yu, Pengyuan Xu, Wunan Mi, Xuanjiang Zhao, Qian Guo, Honglin Zheng, Taiqi Zhao, Qiang Li, Di Lu, Mingxuan Duan, Chaoyang Yu, Ruhao Wu, Shiqian Zhang, Haonan Zhang, Zeyu Wang, Youyang Zheng, Yan Xiao, Zenglei Zhang, Ge Zhang   +22 more
wiley   +1 more source

Research progress on histone deacetylases in peritoneal dialysis-associated peritoneal fibrosis. [PDF]

Ren Fail
Qiu W, Chen J, Behera TR, Huang Y, Chu C, Xu B, Shen Q, Yan J.   +7 more
europepmc   +1 more source

Supplementary Figure 4 from Histone Deacetylase Regulation of ATM-Mediated DNA Damage Signaling

, 2023
K. Ted Thurn, Scott Thomas, Paromita Raha, Ian Qureshi, Pamela N. Münster   +4 more
openalex   +1 more source

Design and Synthesis of Polyamine‐Proteolysis Targeting Chimera Conjugates for Histone Deacetylase (HDAC) Degradation with Enhanced Cellular Uptake

ChemistryOpen, EarlyView.
In this article, proteolysis targeting chimeras (PROTACs) bearing a polyamine linker capable of crossing cancer cell membranes via the polyamine transport system are synthesized and evaluated. The results provide valuable insights for the design of PROTACs with enhanced cellular uptake efficiency.
Yanran Liu, Wentian Chen, Yanwei Shang, Chaonan Tang, Xianming Zeng, Jun Li, Wenting Du   +6 more
wiley   +1 more source