Results 251 to 260 of about 98,157 (333)

Evaluation of Anti-Cancer Properties of Selective Histone Deacetylase 6 Inhibitors in Uveal Melanoma

, 2021
Husvinee Sundaramurthi, S. Garcia Mulero, Melody Buckley, Josep M. Piulats, Breandán N. Kennedy   +4 more
openalex   +1 more source

Identification and Validation of Biomarkers in Chronic Rhinosinusitis With Nasal Polyps and Study of Their Associated Mechanisms

World Journal of Otorhinolaryngology - Head and Neck Surgery, EarlyView.
ABSTRACT Background Cell senescence (CS) and lipid metabolism (LM) disorders have been reported in chronic rhinosinusitis with nasal polyps (CRSwNP). However, the mechanism is still unclear. Methods Data were obtained from public databases; differential expression analysis and machine learning were performed to identify biomarkers and to understand the
Hui‐Yi Deng, Hui‐Jun Qiu, Ming‐Rui Pan, Qin‐Tai Yang   +3 more
wiley   +1 more source

Regulation of cardiovascular diseases by histone deacetylases and NADPH oxidases. [PDF]

Redox Biol
Yan H, Yin Y, Zhou Y, Li Z, Li Y, Ren L, Wen J, Wang W.   +7 more
europepmc   +1 more source

Allergic Sensitization to Inhalant Allergens in the Upper Respiratory Tract—the B Cell Side

Allergy, EarlyView.
ABSTRACT Allergic diseases are on the rise worldwide, driven by respiratory epithelial barrier dysfunction that promotes sensitization to inhalant allergens such as pollen, dust mites, pet dander, and fungal spores. These antigens trigger IgE‐mediated immune responses that lead to diseases such as allergic rhinitis (AR) and asthma.
Ola Grimsholm, Mohammed Zghaebi, Bita Hambrecht, Tanja Kalic, Christopher C. Udoye, Rudolf Manz, Barbara Bohle, Katarzyna M. Sitnik, Julia Eckl‐Dorna, Heimo Breiteneder   +9 more
wiley   +1 more source

Epigenomics Nutritional Insights of <i>Crocus sativus</i> L.: Computational Analysis of Bioactive Molecules Targeting DNA Methyltransferases and Histone Deacetylases. [PDF]

Int J Mol Sci
Piergentili A, Saraceni PR, Demurtas OC, Benassi B, Arcangeli C.   +4 more
europepmc   +1 more source

Targeted Degradation of Histone Deacetylase 8 Using Proteolysis Targeting Chimeras Technology: A Promising Approach for Glioblastoma Treatment

Jiranan Chotitumnavee, Peeratchai Seemaung, Rapeewan Settacomkul, Ratchanon Sukprasert, Yukihiro Itoh, Takayoshi Suzuki, Sirada Srihirun, Christopher Power, Pornpun Vivithanaporn   +8 more
openalex   +1 more source

Identification of MEF2A, MEF2C, and MEF2D interactomes in basal and Fsk‐stimulated mouse MA‐10 Leydig cells

Andrology, EarlyView.
Abstract Background Myocyte enhancer factor 2 transcription factors regulate essential transcriptional programs in various cell types. The activity of myocyte enhancer factor 2 factors is modulated through interactions with cofactors, chromatin remodelers, and other regulatory proteins, which are dependent on cell context and physiological state.
Karine de Mattos, Marie‐Pier Scott‐Boyer, Arnaud Droit, Robert S. Viger, Jacques J. Tremblay   +4 more
wiley   +1 more source

HIV-1 accessory protein Vpr possesses a cryptic p300-dependent transcription-promoting activity that is blocked by histone deacetylases in CD4+ T cells. [PDF]

PLoS Pathog
Lewis CA, Margolis DM, Browne EP.
europepmc   +1 more source

Clonal haematopoiesis in T‐follicular helper cell lymphoma: A prognostic biomarker and early event in lymphoma evolution

British Journal of Haematology, EarlyView.
Summary T‐follicular helper cell lymphomas (TFHLs) are frequently associated with epigenetic mutations and clonal haematopoiesis (CH), but the clinical and prognostic implications of CH in TFHL remains unclear. We performed next‐generation sequencing on paired peripheral blood (PB) and tumour tissue samples from 30 patients with TFHL. CH was defined by
Chong Wei, Yan Zhang, Danqing Zhao, Wei Zhang, Daobin Zhou   +4 more
wiley   +1 more source

Mycosis fungoides and Sézary syndrome

British Journal of Haematology, EarlyView.
Summary Mycosis fungoides (MF) and Sézary syndrome (SS) are the most common cutaneous T‐cell lymphomas, arising from mature CD4+ memory T cells. Diagnosis is complex and relies on clinicopathological correlation, immunophenotyping and molecular clonality testing, while management is stage‐adapted, with potentially curative outcomes achievable only in ...
Francisco Martins, Joana Calvão
wiley   +1 more source