Results 271 to 280 of about 360,616 (327)

Dual Targeting EZH2 and Histone Deacetylases in Human Uterine Sarcoma Cells Under Both 2D and 3D Culture Conditions. [PDF]

J Cell Mol Med
Omran MM, Vafaei S, Alkhrait S, Yang Q, Al-Hendy A.   +4 more
europepmc   +1 more source

Histone deacetylases: potential therapeutic targets for idiopathic pulmonary fibrosis. [PDF]

Front Cell Dev Biol
Cheng HP, Jiang SH, Cai J, Luo ZQ, Li XH, Feng DD.   +5 more
europepmc   +1 more source

Histone Deacetylases

, 2008
Deacetylation of histones is required for gene regulation and cell cycle progression and the mediators, the histone deacetylases, are being vigorously pursued as drug targets for cancer chemotherapy. The deacetylases are also potential drug targets against infectious diseases and genome sequencing revealed proteins of this class in each of three ...
Horn, David, Horn, David; id_orcid, David Horn   +2 more
openaire   +4 more sources

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Histone deacetylases and atherosclerosis.

Atherosclerosis, 2015
Atherosclerosis is the most common pathological process that leads to cardiovascular diseases, a disease of large- and medium-sized arteries that is characterized by a formation of atherosclerotic plaques consisting of necrotic cores, calcified regions, accumulated modified lipids, smooth muscle cells (SMCs), endothelial cells, leukocytes, and foam ...
Xia-Xia Zheng, T. Zhou, Xin-An Wang, Xiao-hong Tong, Jia-Wang Ding   +4 more
semanticscholar   +3 more sources

Histone deacetylase inhibitors

European Journal of Medicinal Chemistry, 2005
AbstractFor Abstract see ChemInform Abstract in Full Text.
BRESSI JEROME C, GANGLOFF ANTHONY R, KWOK LILY   +2 more
openaire   +6 more sources

Histone deacetylases

Current Opinion in Pharmacology, 2003
Post-translational modification of the histones of chromatin has a fundamental role in regulating gene expression. Enzymes involved in these epigenetic events include histone deacetylases (class I and class II), which can be inhibited by a structurally diverse group of small molecules.
Paul A, Marks, Thomas, Miller, Victoria M, Richon   +2 more
openaire   +2 more sources

Histone Deacetylase Inhibitors

ChemInform, 2003
AbstractFor Abstract see ChemInform Abstract in Full Text.
Thomas A, Miller, David J, Witter, Sandro, Belvedere   +2 more
openaire   +2 more sources

Assays for Histone Deacetylases

Current Topics in Medicinal Chemistry, 2009
Epigenetics is defined as heritable changes in gene expression, i.e. the presentation of a certain phenotype, without alterations to the genetic code. This is a central phenomenon in developmental biology but also for the pathogenesis of a variety of diseases, e.g. for cancer in the case of silencing of tumor suppressor proteins.
Hauser, Alexander-Thomas, Jung, Manfred, Jung, Mira   +2 more
openaire   +2 more sources