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Histone Deacetylase Activity Assay
2009Histone deacetylases (HDACs) are enzymes that catalyze the removal of acetyl groups from the epsilon-amino groups of conserved lysine residues in the amino terminal tail of histones. In humans, there are 18 potential deacetylase enzymes that are responsible for the removal of acetyl groups and maintenance of the equilibrium of lysine acetylation on ...
Zhigang, Yuan +3 more
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Histone deacetylases (HDAC) are enzymes that regulate biological activity through removal of acetyl groups from histones and non-histone proteins. A few HDAC inhibitors have been approved for use as anti-cancer agents, but their clinical uptake so far has been limited, presumably due to their adverse effect profiles.
Shunsheng Zheng +3 more
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Shunsheng Zheng +3 more
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Modulation of cellular processes by histone and non-histone protein acetylation
Nature Reviews Molecular Cell Biology, 2022Maria Shvedunova, Asifa Akhtar
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Histone deacetylases and their inhibitors in cancer, neurological diseases and immune disorders
Nature Reviews Drug Discovery, 2014Ricky w Johnstone
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The Rpd3/Hda1 family of lysine deacetylases: from bacteria and yeast to mice and men
Nature Reviews Molecular Cell Biology, 2008Xiang-Jiao Yang, Edward Seto
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Transcriptional Repression by Histone Deacetylases in Plants
Molecular Plant, 2014Xun-Cheng Liu +2 more
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