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Histone deacetylase in neuropathology
2021Neuroepigenetics, a new branch of epigenetics, plays an important role in the regulation of gene expression. Neuroepigenetics is associated with holistic neuronal function and helps in formation and maintenance of memory and learning processes. This includes neurodevelopment and neurodegenerative defects in which histone modification enzymes appear to ...
Rohan, Gupta +2 more
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Histone deacetylases and cancer: causes and therapies
Nature Reviews. Cancer, 2001 Together, histone acetyltransferases and histone deacetylases (HDACs) determine the acetylation status of histones. This acetylation affects the regulation of gene expression, and inhibitors of HDACs have been found to cause growth arrest ...
P. Marks +5 more
semanticscholar +2 more sources
HISTONE DEACETYLASE INHIBITORS
2004The base sequence of DNA provides the genetic code for proteins. The regulation of expression or suppression of gene transcription is largely determined by the structure of the chromatin--referred to as epigenetic gene regulation (Agalioti et al., 2002; Jenuwein and Allis, 2001; Richards and Elgin, 2002; Spotswood and Turner, 2002; Zhang and Reinberg ...
JOEL SIMON, MARSON CHARLES, SAVY PASCAL
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Histone deacetylases in cardiovascular and metabolic diseases.
Journal of Molecular and Cellular Cardiology, 2019Histone deacetylases (HDACs) regulate gene transcription by catalyzing the removal of acetyl groups from key lysine residues in nucleosomal histones and via the recruitment of other epigenetic regulators to DNA promoter/enhancer regions.
Rushita A. Bagchi, K. Weeks
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The role of histone deacetylases in cardiac energy metabolism in heart diseases
Metabolism: Clinical and Experimental, 2023Bo Wei, Xueli Xu
exaly
Histone deacetylases and their inhibitors in cancer, neurological diseases and immune disorders
Nature reviews. Drug discovery, 2014K. Falkenberg, R. Johnstone
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Role of Histone Deacetylases in T-Cell Development and Function
International Journal of Molecular Sciences, 2022Katarzyna Iżykowska
exaly