Results 271 to 280 of about 53,238 (282)

A cyclodextrin-capped histone deacetylase inhibitor

Bioorganic & Medicinal Chemistry Letters, 2013
We have synthesized a β-cyclodextrin (βCD)-capped histone deacetylase (HDAC) inhibitor 3 containing an alkyl linker and a zinc-binding hydroxamic acid motif. Biological evaluation (HDAC inhibition studies) of 3 enabled us to establish the effect of replacing an aryl cap (in SAHA (vorinostat,)) 1 by a large saccharidic scaffold "cap".
Jahangir, Amin, Antonino, Puglisi, James, Clarke, John, Milton, Minghua, Wang, Ronald M, Paranal, James E, Bradner, John, Spencer   +7 more
openaire   +2 more sources

Histone Deacetylase Inhibitors in Psoriasis Therapy

Current Drug Target -Inflammation & Allergy, 2004
Psoriasis is recognised as a multifactorial disease with inflammatory, proliferative, angiogenic and genetic components contributing to the pathology. The disease, which may vary in intensity, remains clinically unmet although there have been several recent advances that have had a substantial impact on suffering.
Fiona, McLaughlin, Nicholas B, La Thangue   +1 more
openaire   +2 more sources

Histone deacetylase inhibitors in cancer therapy

Expert Opinion on Investigational Drugs, 2007
Histones are a family of nuclear proteins that interact with DNA, resulting in DNA being wrapped around a core of histone octamer within the nucleosome. Acetylation/deacetylation of histones is an important mechanism that regulates gene expression and chromatin remodeling.
Walid K, Rasheed, Ricky W, Johnstone, H Miles, Prince   +2 more
openaire   +2 more sources

Histone deacetylase inhibitors: novel anticancer agents

Expert Opinion on Investigational Drugs, 1999
Previous studies have established that the regulation of gene expression is dependent upon the nucleosomal integrity of nuclear DNA. To a large extent, this integrity is dictated by the acetylation status of the core histone particles. The acetylation of histones is, in turn, controlled by the combined activity of specific acetylases and deacetylases ...
Saunders, Nicholas A., Popa, Claudia, Serewko, Magdalena M., Jones, Susan J., Dicker, Anthony J., Dahler, Alison L.   +5 more
openaire   +3 more sources

Novel Histone Deacetylase Inhibitors

2002
Abstract : Advanced breast cancer is not curable by existing treatment regimens. The purpose of this project is to discover new drugs to treat breast cancer that act to restore the differentiated and non-growing state of breast tumor cells by inhibition of histone deacetylase.
Anna R. Martirosyan, Jeannine S. Strobl
openaire   +1 more source

Histone Deacetylase Inhibitors in Cancer Therapy

Cancer Investigation, 2006
Histone acetylation is an important determinant of chromatin organization and gene expression. The nucleosome is the basic repeating unit of chromatin structure and consists of a 146 base pairs of ...
openaire   +2 more sources

Inhibitors of Histone-deacetylases

Tumori Journal, 2001
openaire   +3 more sources

Histone Deacetylase Inhibitors

2010
Michael H. Bloch, Michael H. Bloch, Mark A. Geyer, David C. S. Roberts, Eileen M. Joyce, Jonathan P. Roiser, John H. Halpern, Joji Suzuki, Pedro E. Huertas, Torsten Passie, John H. Halpern, Joji Suzuki, Pedro E. Huertas, Torsten Passie, Joji Suzuki, Torsten Passie, Pedro E. Huertas, John H. Halpern, Joji Suzuki, Torsten Passie, Pedro E. Huertas, John H. Halpern, David E. Nichols, Marie-Louise G. Wadenberg, Trevor W. Robbins, David S. Baldwin, Sophie Tambour, John C. Crabbe, Lucio Tremolizzo, Gessica Sala, Carlo Ferrarese, Brian L. Odlaug, Jon E. Grant, Paul D. Callaghan, Iain S. McGregor, Murray R. Thompson, Sarah Morgan, Angus Mackay, E. Ernst, Lawrence H. Price, Michael M. Morgan, MacDonald J. Christie, Susan Jones, Andrew Young, Elizabeth C. Warburton, Stephen J. Hill, Anthony R. Isles, Lawrence S. Wilkinson, Subhash C. Pandey, Subhash C. Pandey, Subhash C. Pandey, Aldo Badiani, James Winslow, Susan Jones, Jill B. Becker, Lucio Tremolizzo, Gessica Sala, Carlo Ferrarese, Paul D. Callaghan, Iain S. McGregor, Murray R. Thompson, David E. Nichols, Jason C. G. Halford, Stephen B. Dunnett, Martine Cador, Naheed (Max) Mirza, Andrea Bari, Yesne Alici, William Breitbart, Andrea Bari, Becky Kinkead, Charles B. Nemeroff, Lucy C. Guillory, Jason C. G. Halford, Ennio Esposito, William Invernizzi, Gary Remington, Tomasz Schneider, Michel Billiard, Michel Billiard, Alyson J. Bond, Paolo Nencini, Michele S. Milella, Brian E. Leonard, Yesne Alici, William Breitbart, Luis de Lecea, Michel Billiard, Samuel B. Hutton, Jason C. G. Halford, R. H. De Rijk, E. R. de Kloet, Tooru M. Mizuno, Maria Isabel Colado, A. Richard Green   +94 more
openaire   +1 more source

Histone Deacetylase Inhibitors

2014
openaire   +1 more source

209 Histone deacetylase inhibitors

Lung Cancer, 2006
openaire   +1 more source