Results 31 to 40 of about 28,454 (236)
Histone Demethylase AMX-1 Regulates Fertility in a p53/CEP-1 Dependent Manner
Frontiers in Genetics, 2022 Histone methylation shapes the epigenetic configuration and adjusts multiple fundamental nuclear processes, including transcription, cell cycle control and DNA repair.
Xiaojing Ren +4 more
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Histone demethylation maintains Prdm14 and Tsix expression and represses xIst in embryonic stem cells. [PDF]
PLoS ONE, 2015 Epigenetic reprogramming is exemplified by the remarkable changes observed in cellular differentiation and X-chromosome inactivation (XCI) in mammalian female cells.
Yasunao F Kamikawa, Mary E Donohoe
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Histone demethylases in chromatin cross‐talks [PDF]
Biology of the Cell, 2011 The ‘histone code’ hypothesis states that chromatin‐based regulation of nuclear processes such as transcription is brought about by the combination of distinct modifications (histone marks) at specific loci. Its correct establishment involves chromatin cross‐talks, ensuring an ordered and concerted deposition/removal of a particular set of ...
Laure, Verrier +2 more
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Breast Cancer: Basic and Clinical Research, 2016 The Jumonji-containing domain protein, KDM4C, is a histone demethylase associated with the development of several forms of human cancer. However, its specific function in the viability of tumoral lineages is yet to be determined.
Jeison Garcia, Fernando Lizcano
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The Plant Pathology Journal, 2017 Histone methylation plays important roles in regulating chromatin dynamics and transcription in eukaryotes. Implication of histone modifications in fungal pathogenesis is, however, beginning to emerge.
Aram Huh +4 more
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JMJD3 is a histone H3K27 demethylase [PDF]
Cell Research, 2007 Histone methylation is an important epigenetic phenomenon that participates in a diverse array of cellular processes and has been found to be associated with cancer. Recent identification of several histone demethylases has proved that histone methylation is a reversible process.
Yang, Xiang +5 more
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Discovery and structural studies of histone demethylases
Frontiers in Epigenetics and EpigenomicsThe discovery and structural elucidation of histone demethylases represent a groundbreaking advancement in the field of epigenetics. Histone methylation, a critical chromatin modification, was long regarded as irreversible until the identification of ...
Longfei Peng +5 more
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Toxicology Reports, 2014 Background: Epigenetic modifications, particularly DNA methylation and posttranslational histone modifications regulate heritable changes in transcription without changes in the DNA sequence.
Divya Teja Vavilala +6 more
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Essential functions of the histone demethylase lid. [PDF]
PLoS Genetics, 2010 Drosophila Little imaginal discs (Lid) is a recently described member of the JmjC domain class of histone demethylases that specifically targets trimethylated histone H3 lysine 4 (H3K4me3). To understand its biological function, we have utilized a series
Ling Li +3 more
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Histone demethylase lysine demethylase 5B in development and cancer
Oncotarget, 2016 Histone methylation is one of the most important chromatin posttranslational modifications. It has a range of influences on nuclear functions including epigenetic inheritance, transcriptional regulation and the maintenance of genome integrity. Changes in histone methylation status take part in various physiological and pathological processes.
Han, Mengjiao +4 more
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