Results 131 to 140 of about 197,157 (312)

Losing the maternal effect gene Nlrp2 alters the ovulated mouse oocytes transcriptome and impacts histone demethylase KDM1B expression [PDF]

, 2022
Zahra Anvar, Imen Chakchouk, Momal Sharif, Sangeetha Mahadevan, Eleni Nasiotis, Li Su, Zhandong Liu, Ying‐Wooi Wan, Ignatia B. Van den Veyver   +8 more
openalex   +1 more source

Histone H3K27me3 demethylases regulate human Th17 cell development and effector functions by impacting on metabolism

Proceedings of the National Academy of Sciences of the United States of America, 2019
Significance T cells control many immune functions, with Th17 cells critical in regulating inflammation. Following activation, T cells undergo metabolic reprogramming and utilize glycolysis to increase the ATP availability.
A. Cribbs, S. Terlecki-Zaniewicz, M. Philpott, J. Baardman, D. Ahern, M. Lindow, S. Obad, H. Oerum, B. Sampey, P. Mander, H. Penn, Paul Wordsworth, P. Bowness, R. Prinjha, M. Winther, M. Feldmann, U. Oppermann   +16 more
semanticscholar   +1 more source

Bridging maternal effects and epitranscriptomics: A novel perspective in developmental biology

Developmental Dynamics, EarlyView.
Abstract Maternal effects, encompassing both genetic (maternally expressed gene products) and non‐genetic (maternal state) influences, are powerful determinants of offspring phenotype, yet their RNA‐level mechanisms remain incompletely resolved. In parallel, epitranscriptomics, an emerging field centered on chemical modifications to RNA, has revealed ...
Ehsan Pashay Ahi
wiley   +1 more source

Protein complex interactor analysis and differential activity of KDM3 subfamily members towards H3K9 methylation.

PLoS ONE, 2013
Histone modifications play an important role in chromatin organization and gene regulation, and their interpretation is referred to as epigenetic control. The methylation levels of several lysine residues in histone tails are tightly controlled, and JmjC
Michael Brauchle, Zhiping Yao, Rishi Arora, Sachin Thigale, Ieuan Clay, Bruno Inverardi, Joy Fletcher, Paul Taslimi, Michael G Acker, Bertran Gerrits, Johannes Voshol, Andreas Bauer, Dirk Schübeler, Tewis Bouwmeester, Heinz Ruffner   +14 more
doaj   +1 more source

Histone H3 K4/9/27 Trimethylation Levels Affect Wound Healing and Stem Cell Dynamics in Adult Skin

Stem Cell Reports, 2020
Summary: Epigenetic mechanisms controlling adult mammalian stem cell (SC) dynamics might be critical for tissue regeneration but are poorly understood.
Sangjo Kang, Kylie Long, Sherry Wang, Aiko Sada, Tudorita Tumbar   +4 more
doaj   +1 more source

Histone demethylases in chromatin biology and beyond

EMBO Reports, 2015
Histone methylation plays fundamental roles in regulating chromatin‐based processes. With the discovery of histone demethylases over a decade ago, it is now clear that histone methylation is dynamically regulated to shape the epigenome and regulate ...
Emilia Dimitrova, Anne H. Turberfield, R. Klose   +2 more
semanticscholar   +1 more source

Epigenotoxicity: Decoding the epigenetic imprints of genotoxic agents and their implications for regulatory genetic toxicology

Environmental and Molecular Mutagenesis, EarlyView.
Abstract Regulatory genetic toxicology focuses on DNA damage and subsequent gene mutations. However, genotoxic agents can also affect epigenetic marks, and incorporation of epigenetic data into the regulatory framework may thus enhance the accuracy of risk assessment.
Roger Godschalk, Christopher Faulk, Jessica LaRocca, Jan van Benthem, Francesco Marchetti   +4 more
wiley   +1 more source

Elevated H3K27me3 levels sensitize osteosarcoma to cisplatin

Clinical Epigenetics, 2019
Background In osteosarcoma (OS), chemotherapy resistance has become one of the greatest issues leading to high mortality among patients. However, the mechanisms of drug resistance remain elusive, limiting therapeutic efficacy. Here, we set out to explore
Chao He, Jian Sun, Chao Liu, Yuhang Jiang, Yongqiang Hao   +4 more
doaj   +1 more source

Histone Posttranslational Modifications of CD4+ T Cell in Autoimmune Diseases [PDF]

, 2016
published_or_final_versio
Lau, WCS, Lu, Q, Wang, Z, Yin, H
core   +1 more source

Loss of the Y Chromosome in Oral Potentially Premalignant Disorders Predicts Malignant Progression: An Integrative Cross‐Species Multi‐Cohort Bioinformatic Study

Head &Neck, EarlyView.
ABSTRACT Background The loss of the Y chromosome (LOY) and the extreme down‐regulation of Y chromosome gene expression (EDY) are frequently observed in oral squamous cell carcinoma (OSCC). However, their roles in oral potentially malignant disorders (OPMDs) are unclear.
Rui Han, Jos B. Poell, Cristina Conde‐Lopez, Tuula Salo, Ina Kurth, Ruud H. Brakenhoff, Jochen Hess   +6 more
wiley   +1 more source