Results 51 to 60 of about 197,157 (312)
chroGPS, a global chromatin positioning system for the functional analysis and visualization of the epigenome [PDF]
, 2013 Development of tools to jointly visualize the genome and the epigenome remains a challenge. chroGPS is a computational approach that addresses this question.
Font-Burgada, Joan +3 more
core +1 more source
JMJD family proteins in cancer and inflammation
Signal Transduction and Targeted Therapy, 2022 The occurrence of cancer entails a series of genetic mutations that favor uncontrollable tumor growth. It is believed that various factors collectively contribute to cancer, and there is no one single explanation for tumorigenesis.
Wang Manni +4 more
doaj +1 more source
Hitting histone demethylases [PDF]
Science-Business eXchange, 2012 A GSK–Structural Genomics Consortium team has identified the first potent and selective histone demethylase inhibitor and shown that the molecule dampens the macrophage inflammatory response. The pharma now is focusing on internal efforts and external approaches to exploring potential therapeutic applications of the inhibitor.
openaire +1 more source
Lung Cancer Therapy Targeting Histone Methylation: Opportunities and Challenges
Computational and Structural Biotechnology Journal, 2018 Lung cancer is one of the most common malignancies. In spite of the progress made in past decades, further studies to improve current therapy for lung cancer are required.
Yuchen Chen +5 more
doaj +1 more source
Targeting epigenetic regulators to overcome drug resistance in cancers
Signal Transduction and Targeted Therapy, 2023 Drug resistance is mainly responsible for cancer recurrence and poor prognosis. Epigenetic regulation is a heritable change in gene expressions independent of nucleotide sequence changes.
Nan Wang, Ting Ma, Bin Yu
doaj +1 more source
Poly(ADP-ribosyl)ation is involved in the epigenetic control of TET1 gene transcription [PDF]
, 2014 TET enzymes are the epigenetic factors involved in the formation of the Sixth DNA base 5-hydroxymethylcytosine, whose deregulation has been associated with tumorigenesis.
Bacalini, MARIA GIULIA +9 more
core +6 more sources
Genomics Data, 2015 Histone lysine (K) methylation is a type of epigenetic modification involved in regulation of DNA-based processes, including transcription, replication and repair.
Wei Zhao +3 more
doaj +1 more source
The emerging roles for histone demethylases in the modulation of signaling pathways
Biomolecular Concepts, 2013 Since their discovery in 2004, histone demethylases have emerged as key regulators of chromatin. Recent studies have started to reveal the interconnections between histone demethylases and signaling pathways, suggesting that this interplay drives ...
Di Stefano Luisa, Dyson Nicholas J.
doaj +1 more source
Highly selective inhibition of histone demethylases by de novo macrocyclic peptides
Nature Communications, 2017 The JmjC histone demethylases (KDMs) are linked to tumour cell proliferation and are current cancer targets; however, very few highly selective inhibitors for these are available.
A. Kawamura +18 more
semanticscholar +1 more source
Histone lysine demethylases in breast cancer [PDF]
Critical Reviews in Oncology/Hematology, 2013 Histone lysine demethylases (KDMs) have been recently discovered in mammals and have been nicknamed "erasers" for their ability to remove methyl groups from histone substrates. In cancer cells, KDMs can activate or repress gene transcription, behaving as oncogenes or tumor suppressors depending upon the cellular context.
PAOLICCHI, ELISA +4 more
openaire +2 more sources