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Current Perspectives on Histone Demethylases [PDF]
Acta Biochimica et Biophysica Sinica, 2007 The posttranslational modification of histones plays an important role in chromatin regulation. Histone methylation influences constitutive heterochromatin, genomic imprinting, X-chromosome inactivation and gene transcription. Histone demethylase catalyzes the removal of methyl groups on lysine or arginine residues of histones.
Xiaoqing, Tian, Jingyuan, Fang
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Histone Demethylases in Colon Cancer [PDF]
Current Colorectal Cancer Reports, 2014 Cell growth and proliferation are controlled through different posttranslational modifications including demethylation, a process regulated by regulated by the demethylase enzymes. This review focuses on our current understanding of functional and therapeutic potentials of histone demethylases in colon cancer.
Santanu, Paul +5 more
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The emerging roles for histone demethylases in the modulation of signaling pathways
Biomolecular Concepts, 2013 Since their discovery in 2004, histone demethylases have emerged as key regulators of chromatin. Recent studies have started to reveal the interconnections between histone demethylases and signaling pathways, suggesting that this interplay drives ...
Di Stefano Luisa, Dyson Nicholas J.
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Genomics Data, 2015 Histone lysine (K) methylation is a type of epigenetic modification involved in regulation of DNA-based processes, including transcription, replication and repair.
Wei Zhao +3 more
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In Vitro Histone Demethylase Assay [PDF]
Cold Spring Harbor Protocols, 2010 INTRODUCTIONPost-translational modifications of histones play an important role in regulating chromatin dynamics and function. One of the modifications, methylation, occurs on both lysine and arginine residues, and methylation status defines the epigenetic program of a cell by determining chromatin structure and thereby regulating DNA-dependent ...
Yu-ichi, Tsukada, Keiichi I, Nakayama
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G3: Genes, Genomes, Genetics, 2016 Histone methylation levels, which are determined by the action of both histone demethylases and methyltransferases, impact multiple biological processes by affecting gene expression activity.
Mengying Liu +2 more
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Frontiers in Cell and Developmental Biology, 2022 Epithelial cancer cells that lose attachment from the extracellular matrix (ECM) to seed in a distant organ often undergo anoikis’s specialized form of apoptosis. Recently, KDM3A (H3K9 demethylase) has been identified as a critical effector of anoikis in
Mohammed Razeeth Shait Mohammed +9 more
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Human Histone Demethylase LSD1 Reads the Histone Code [PDF]
Journal of Biological Chemistry, 2005 Human histone demethylase LSD1 is a flavin-dependent amine oxidase that catalyzes the specific removal of methyl groups from mono- and dimethylated Lys4 of histone H3. The N-terminal tail of H3 is subject to various covalent modifications, and a fundamental question in LSD1 biology is how these epigenetic marks affect the demethylase activity.
F. Forneris +4 more
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PLoS ONE, 2010 BackgroundSmall molecule modulators of epigenetic processes are currently sought as basic probes for biochemical mechanisms, and as starting points for development of therapeutic agents.
Oliver N F King +16 more
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BMC Evolutionary Biology, 2008 Background Histone methylation can dramatically affect chromatin structure and gene expression and was considered irreversible until recent discoveries of two families of histone demethylases, the KDM1 (previously LSD1) and JmjC domain-containing ...
Zhou Xiaofan, Ma Hong
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