Results 31 to 40 of about 19,155 (194)
SMARCA4 deficient tumours are vulnerable to KDM6A/UTX and KDM6B/JMJD3 blockade
Nature Communications, 2021 SMARCA4 is commonly inactivated in lung and ovarian cancers. Here the authors show that SMARCA4-deficient tumours have significantly reduced levels of the histone demethylases KDM6s and a strong dependency on these demethylases for tumour growth, so that
Octavio A. Romero +19 more
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Cells, 2022 Epigenetic aberrations, associated with altered DNA methylation profiles and global changes in the level of histone modifications, are commonly detected in head and neck squamous cell carcinomas (HNSCC).
Dawid Dorna, Jarosław Paluszczak
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Targeting epigenetic regulators to overcome drug resistance in cancers
Signal Transduction and Targeted Therapy, 2023 Drug resistance is mainly responsible for cancer recurrence and poor prognosis. Epigenetic regulation is a heritable change in gene expressions independent of nucleotide sequence changes.
Nan Wang, Ting Ma, Bin Yu
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Lung Cancer Therapy Targeting Histone Methylation: Opportunities and Challenges
Computational and Structural Biotechnology Journal, 2018 Lung cancer is one of the most common malignancies. In spite of the progress made in past decades, further studies to improve current therapy for lung cancer are required.
Yuchen Chen +5 more
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JMJD family proteins in cancer and inflammation
Signal Transduction and Targeted Therapy, 2022 The occurrence of cancer entails a series of genetic mutations that favor uncontrollable tumor growth. It is believed that various factors collectively contribute to cancer, and there is no one single explanation for tumorigenesis.
Wang Manni +4 more
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Human Histone Demethylase LSD1 Reads the Histone Code [PDF]
Journal of Biological Chemistry, 2005 Human histone demethylase LSD1 is a flavin-dependent amine oxidase that catalyzes the specific removal of methyl groups from mono- and dimethylated Lys4 of histone H3. The N-terminal tail of H3 is subject to various covalent modifications, and a fundamental question in LSD1 biology is how these epigenetic marks affect the demethylase activity.
F. Forneris +4 more
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Genomics Data, 2015 Histone lysine (K) methylation is a type of epigenetic modification involved in regulation of DNA-based processes, including transcription, replication and repair.
Wei Zhao +3 more
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The emerging roles for histone demethylases in the modulation of signaling pathways
Biomolecular Concepts, 2013 Since their discovery in 2004, histone demethylases have emerged as key regulators of chromatin. Recent studies have started to reveal the interconnections between histone demethylases and signaling pathways, suggesting that this interplay drives ...
Di Stefano Luisa, Dyson Nicholas J.
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Demethylase Activity Is Directed by Histone Acetylation [PDF]
Journal of Biological Chemistry, 2001 Mammalian genomes are compartmentalized into dense inactive chromatin that is hypermethylated and active open chromatin that is hypomethylated. It is generally accepted that this bimodal pattern of methylation is established during development and is then faithfully inherited through subsequent cell divisions by a maintenance DNA methyltransferase ...
N, Cervoni, M, Szyf
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Histone Demethylases and Their Roles in Cancer Epigenetics [PDF]
Journal of Medical Oncology and Therapeutics, 2016 The genetic abnormalities that drive tumorigenesis are usually coupled with epigenetic alterations, such as DNA methylation and aberrant histone modifications, which may help oncogenic drivers accelerate cancer progression, metastasis, and therapy resistance.
Alexandra, D'Oto +3 more
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