Results 51 to 60 of about 27,890 (158)

Identification of Histone Demethylases in Saccharomyces cerevisiae [PDF]

Journal of Biological Chemistry, 2007
Based on the prediction that histone lysine demethylases may contain the JmjC domain, we examined the methylation patterns of five knock-out strains (ecm5Delta, gis1Delta, rph1Delta, jhd1Delta, and jhd2Delta (yjr119cDelta)) of Saccharomyces cerevisiae.
Shengjiang, Tu, Esther M M, Bulloch, Lanhao, Yang, Chen, Ren, Wei-Chieh, Huang, Pang-Hung, Hsu, Chein-Hung, Chen, Chung-Lin, Liao, Hui-Ming, Yu, Wan-Sheng, Lo, Michael A, Freitas, Ming-Daw, Tsai   +11 more
openaire   +2 more sources

Contrasting roles of histone 3 lysine 27 demethylases in acute lymphoblastic leukaemia [PDF]

, 2013
T-cell acute lymphoblastic leukaemia (T-ALL) is a haematological malignancy with a dismal overall prognosis, including a relapse rate of up to 25%, mainly because of the lack of non-cytotoxic targeted therapy options.
A Subramanian, A Tsirigos, AA Mansour, Adolfo A. Ferrando, Alexandros Strikoudis, AM Jankowska, AP Weng, Aristotelis Tsirigos, B King, B Langmead, BG Mar, Bryan King, C Morales Torres, C Simon, C Wang, CG Mullighan, CG Mullighan, Charles G. Mullighan, DI Marks, Elisabeth Paietta, Evangelia Loizou, F Armstrong, F De Santa, G van Haaften, G. Grant Welstead, GG Welstead, Giovanni Tonon, GL Sen, H Wang, Iannis Aifantis, J Zhang, J Zhang, Jacob M. Rowe, Jared Becksfort, Jasper Mullenders, Jelena Nedjic, JK Wang, K Agger, K Chen, K Jepsen, L Espinosa, L Kruidenier, L Wang, Laurens Kruidenier, Linda Holmfeldt, Luyao Xu, M Barradas, Martin S. Tallman, MR Hubner, P Ntziachristos, P Van Vlierberghe, Panagiotis Ntziachristos, Pieter Van Vlierberghe, PJ Valk, Q Li, RA Dickins, Rab Prinjha, RG Verhaak, Rudolf Jaenisch, S Thieme, S Zhong, SB Baylin, Shizuo Akira, SM Kooistra, Sofia Bakogianni, T Palomero, T Satoh, Takashi Satoh, Thomas Trimarchi, VM Sharma, W Zhao, WA Dik, Y Zhang   +72 more
core   +2 more sources

Hairless is a histone H3K9 demethylase

The FASEB Journal, 2013
The hairless (HR) protein contains a Jumonji C (JmjC) domain that is conserved among a family of proteins with histone demethylase (HDM) activity. To test whether HR possesses HDM activity, we performed a series of in vitro demethylation assays, which demonstrated that HR can demethylate mono‐
Liang, Liu, Hyunmi, Kim, Alex, Casta, Yuki, Kobayashi, Lawrence S, Shapiro, Angela M, Christiano   +5 more
openaire   +3 more sources

Functional Crosstalk between Lysine Methyltransferases on Histone Substrates: The Case of G9A/GLP and Polycomb Repressive Complex 2 [PDF]

, 2015
Significance: Methylation of histone H3 on lysine 9 and 27 (H3K9 and H3K27) are two epigenetic modifications that have been linked to several crucial biological processes, among which are transcriptional silencing and cell differentiation.
Ait Si Ali, Slimane, Mozzetta, Chiara, Pontis, Julien   +2 more
core   +2 more sources

Intrinsic protein disorder in histone lysine methylation [PDF]

, 2016
Histone lysine methyltransferases (HKMTs), catalyze mono-, di- and trimethylation of lysine residues, resulting in a regulatory pattern that controls gene expression.
Horvath, T., Lazar, T., Mészáros, A., Schad, E., Szabó, B., Tantos, Ágnes, Tompa, Péter   +6 more
core   +1 more source

Regulation of NF-κB activity through lysine monomethylation of p65 [PDF]

, 2009
NF-κB is a key activator of inflammatory and immune responses with important pathological roles in cancer, heart disease, and autoimmune diseases. Transcriptional activity of NF-κB is regulated by different posttranslational modifications.
Baltimore, David, Ea, Chee-Kwee
core   +3 more sources

Current epigenetic aspects the clinical kidney researcher should embrace [PDF]

, 2017
Chronic kidney disease (CKD), affecting 10-12% of the world's adult population, is associated with a considerably elevated risk of serious comorbidities, in particular, premature vascular disease and death.
Ekström, Tomas J., Nordfors, Louise, Shiels, Paul G., Stenvinkel, Peter, Van Craenenbroeck, Amaryllis H., Witasp, Anna   +5 more
core   +1 more source

KDM2 family members are regulated by HIF-1 in hypoxia. [PDF]

, 2017
Hypoxia is not only a developmental cue but also a stress and pathological stimulus in many human diseases. The response to hypoxia at the cellular level relies on the activity of the transcription factor family, hypoxia inducible factor (HIF).
Batie, Michael, D'Ignazio, Laura, Druker, Jimena, Rocha, Sonia   +3 more
core   +4 more sources

Polymyxins and quinazolines are LSD1/KDM1A inhibitors with unusual structural features [PDF]

, 2016
Because of its involvement in the progression of several malignant tumors, the histone lysine-specific demethylase 1 (LSD1) has become a prominent drug target in modern medicinal chemistry research.
Ciossani, Giuseppe, Forgione, Mariantonietta, Forneris, Federico, Lucidi, Alessia, Mai, Antonello, Marrocco, Biagina, Mattevi, Andrea, Mehdipour, Parinaz, Pilotto, Simona, Rotili, Dante, Speranzini, Valentina, Velankar, Sameer   +11 more
core   +2 more sources

The histone demethylase UTX regulates the lineage-specific epigenetic program of invariant natural killer T cells [PDF]

, 2018
Invariant natural killer T cells (iNKT cells) are innate-like lymphocytes that protect against infection, autoimmune disease and cancer. However, little is known about the epigenetic regulation of iNKT cell development.
Barnitz, R Anthony, Beyaz, Semir, Das, Partha P, Dogum, Rizkullah, Haining, W Nicholas, Herault, Aurelie, Hu, Yu,M.C.P.Massachusetts Institute of Technology., Huang, Jialiang, Kerenyi, Marc A, Kim, Ji Hyung, Orkin, Stuart H, Passegue, Emmanuelle, Pinello, Luca, Winau, Florian, Xifaras, Michael, Yilmaz, Omer, Yuan, Guo-Cheng   +16 more
core   +1 more source