Additional sex combs interacts with enhancer of zeste and trithorax and modulates levels of trimethylation on histone H3K4 and H3K27 during transcription of hsp70. [PDF]
, 2017 BACKGROUND: Maintenance of cell fate determination requires the Polycomb group for repression; the trithorax group for gene activation; and the enhancer of trithorax and Polycomb (ETP) group for both repression and activation.
Brock, Hugh W +4 more
core +2 more sources
Epigenetic therapy in urologic cancers: an update on clinical trials [PDF]
, 2016 Epigenetic dysregulation is one of many factors that contribute to cancer development and progression. Numerous epigenetic alterations have been identified in urologic cancers including histone modifications, DNA methylation changes, and microRNA ...
Agarwal +111 more
core +1 more source
JARID1 Histone Demethylases: Emerging Targets in Cancer. [PDF]
Trends Cancer, 2017 JARID1 proteins are histone demethylases that both regulate normal cell fates during development and contribute to the epigenetic plasticity that underlies malignant transformation. This H3K4 demethylase family participates in multiple repressive transcriptional complexes at promoters and has broader regulatory effects on chromatin that remain ill ...
Harmeyer KM +3 more
europepmc +4 more sources
Targeting Histone Demethylases in Cancer Therapy [PDF]
Clinical Cancer Research, 2009 Abstract A novel oligoamine analog inhibitor of histone demethylases blocks colon tumor cell growth in association with histone methylation and gene re-expression. It also markedly potentiates the activity of hypomethylating agents in vitro and in vivo, suggesting that histone demethylase inhibitors may represent a valuable addition ...
openaire +2 more sources
Oncometabolites: tailoring our genes [PDF]
, 2015 Increased glucose metabolism in cancer cells is a phenomenon that has been known for over 90 years, allowing maximal cell growth through faster ATP production and redistribution of carbons towards nucleotide, protein and fatty acid synthesis.
Avril N, Buck AC, Gimm O, Higashi K
core +1 more source
Expanding the Role of the Histone Lysine-Specific Demethylase LSD1 in Cancer [PDF]
, 2019 Studies of alterations in histone methylation in cancer have led to the identification of histone methyltransferases and demethylases as novel targets for therapy.
Amente, Stefano +3 more
core +1 more source
LSD1 Histone Demethylase Assays and Inhibition [PDF]
, 2016 The lysine-specific demethylase (LSD1) is a flavin-dependent amine oxidase that selectively removes one or two methyl groups from histone H3 at the Lys4 position. Along with histone deacetylases 1 and 2, LSD1 is involved in epigenetically silencing gene expression. LSD1 has been implicated as a potential therapeutic target in cancer and other diseases.
D, Hayward, P A, Cole
openaire +2 more sources
Jumonji family histone demethylases in neural development [PDF]
Cell and Tissue Research, 2014 Central nervous system (CNS) development is driven by coordinated actions of developmental signals and chromatin regulators that precisely regulate gene expression patterns. Histone methylation is a regulatory mechanism that controls transcriptional programs.
Fueyo, Raquel +2 more
openaire +3 more sources
Homeobox gene expression in acute myeloid leukemia is linked to typical underlying molecular aberrations [PDF]
, 2014 __Background:__ Although distinct patterns of homeobox (HOX) gene expression have been described in defined cytogenetic and molecular subsets of patients with acute myeloid leukemia (AML), it is unknown whether these patterns are the direct result of ...
Drabkin, H.A. (Harry) +10 more
core +1 more source
Poly(ADP-ribosyl)ation is involved in the epigenetic control of TET1 gene transcription [PDF]
, 2014 TET enzymes are the epigenetic factors involved in the formation of the Sixth DNA base 5-hydroxymethylcytosine, whose deregulation has been associated with tumorigenesis.
Bacalini, MARIA GIULIA +9 more
core +6 more sources