Results 41 to 50 of about 19,155 (194)

Disruption of Methionine Metabolism in Drosophila melanogaster Impacts Histone Methylation and Results in Loss of Viability

G3: Genes, Genomes, Genetics, 2016
Histone methylation levels, which are determined by the action of both histone demethylases and methyltransferases, impact multiple biological processes by affecting gene expression activity.
Mengying Liu, Valerie L. Barnes, Lori A. Pile   +2 more
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The Histone H3K27me3 Demethylases KDM6A/B Resist Anoikis and Transcriptionally Regulate Stemness-Related Genes

Frontiers in Cell and Developmental Biology, 2022
Epithelial cancer cells that lose attachment from the extracellular matrix (ECM) to seed in a distant organ often undergo anoikis’s specialized form of apoptosis. Recently, KDM3A (H3K9 demethylase) has been identified as a critical effector of anoikis in
Mohammed Razeeth Shait Mohammed, Mohammed Razeeth Shait Mohammed, Mazin Zamzami, Hani Choudhry, Hani Choudhry, Firoz Ahmed, Firoz Ahmed, Bushra Ateeq, Mohammad Imran Khan, Mohammad Imran Khan   +9 more
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Identification of Histone Demethylases in Saccharomyces cerevisiae [PDF]

Journal of Biological Chemistry, 2007
Based on the prediction that histone lysine demethylases may contain the JmjC domain, we examined the methylation patterns of five knock-out strains (ecm5Delta, gis1Delta, rph1Delta, jhd1Delta, and jhd2Delta (yjr119cDelta)) of Saccharomyces cerevisiae.
Shengjiang, Tu, Esther M M, Bulloch, Lanhao, Yang, Chen, Ren, Wei-Chieh, Huang, Pang-Hung, Hsu, Chein-Hung, Chen, Chung-Lin, Liao, Hui-Ming, Yu, Wan-Sheng, Lo, Michael A, Freitas, Ming-Daw, Tsai   +11 more
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Discovery and structural studies of histone demethylases

Frontiers in Epigenetics and Epigenomics
The discovery and structural elucidation of histone demethylases represent a groundbreaking advancement in the field of epigenetics. Histone methylation, a critical chromatin modification, was long regarded as irreversible until the identification of ...
Longfei Peng, Xinze Li, Hao Yang, Haonan Chen, Yue Yang, Shunfeng Peng   +5 more
doaj   +1 more source

Histone Demethylase LSD1 Regulates Adipogenesis [PDF]

Journal of Biological Chemistry, 2010
Epigenetic mechanisms, in particular the enzymatic modification of histones, are a crucial element of cell differentiation, a regulated process that allows a precursor cell basically to turn into a different cell type while maintaining the same genetic equipment.
Melina M, Musri, Mari Carmen, Carmona, Felicia A, Hanzu, Perla, Kaliman, Ramon, Gomis, Marcelina, Párrizas   +5 more
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Hairless is a histone H3K9 demethylase

The FASEB Journal, 2013
The hairless (HR) protein contains a Jumonji C (JmjC) domain that is conserved among a family of proteins with histone demethylase (HDM) activity. To test whether HR possesses HDM activity, we performed a series of in vitro demethylation assays, which demonstrated that HR can demethylate mono‐
Liang, Liu, Hyunmi, Kim, Alex, Casta, Yuki, Kobayashi, Lawrence S, Shapiro, Angela M, Christiano   +5 more
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Quantitative high-throughput screening identifies 8-hydroxyquinolines as cell-active histone demethylase inhibitors.

PLoS ONE, 2010
BackgroundSmall molecule modulators of epigenetic processes are currently sought as basic probes for biochemical mechanisms, and as starting points for development of therapeutic agents.
Oliver N F King, Xuan Shirley Li, Masaaki Sakurai, Akane Kawamura, Nathan R Rose, Stanley S Ng, Amy M Quinn, Ganesha Rai, Bryan T Mott, Paul Beswick, Robert J Klose, Udo Oppermann, Ajit Jadhav, Tom D Heightman, David J Maloney, Christopher J Schofield, Anton Simeonov   +16 more
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Histone Demethylase Modulation: Epigenetic Strategy to Combat Cancer Progression

Epigenomes, 2023
Epigenetic modifications are heritable, reversible changes in histones or the DNA that control gene functions, being exogenous to the genomic sequence itself. Human diseases, particularly cancer, are frequently connected to epigenetic dysregulations. One
Rashmi Srivastava, Rubi Singh, Shaurya Jauhari, Niraj Lodhi, Rakesh Srivastava   +4 more
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The complex roles of histone demethylases in vivo [PDF]

Cell Cycle, 2011
Eukaryotic genomes are organized into complex chromatin structures. The dynamic regulation of these structures is essential for development and their alterations have been implicated in diseases such as cancer. The combination of post-translational modifications in histones tails determines chromatin structure and influences the transcriptional status ...
Luisa, Di Stefano, Nicholas J, Dyson
openaire   +2 more sources

Evolutionary history of histone demethylase families: distinct evolutionary patterns suggest functional divergence

BMC Evolutionary Biology, 2008
Background Histone methylation can dramatically affect chromatin structure and gene expression and was considered irreversible until recent discoveries of two families of histone demethylases, the KDM1 (previously LSD1) and JmjC domain-containing ...
Zhou Xiaofan, Ma Hong
doaj   +1 more source