Results 21 to 30 of about 19,155 (194)
Histone H4K20 Demethylation by Two hHR23 Proteins
Cell Reports, 2020 Summary: Histone methyl groups can be removed by demethylases. Although LSD1 and JmjC domain-containing proteins have been identified as histone demethylases, enzymes for many histone methylation states or sites are still unknown.
Xiongwen Cao +13 more
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Histone demethylase Jumonji D3 (JMJD3) as a tumor suppressor by regulating p53 protein nuclear stabilization. [PDF]
PLoS ONE, 2012 Histone methylation regulates normal stem cell fate decisions through a coordinated interplay between histone methyltransferases and demethylases at lineage specific genes.
Chibawanye I Ene +18 more
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Biomolecules, 2021 Histone methylation tightly regulates chromatin accessibility, transcription, proliferation, and cell differentiation, and its perturbation contributes to oncogenic reprogramming of cells.
Hans Felix Staehle +2 more
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Histone Lysine Demethylase Inhibitors [PDF]
Cold Spring Harbor Perspectives in Medicine, 2016 The dynamic regulation of covalent modifications to histones is essential for maintaining genomic integrity and cell identity and is often compromised in cancer. Aberrant expression of histone lysine demethylases has been documented in many types of blood and solid tumors, and thus demethylases represent promising therapeutic targets.
Ashwini, Jambhekar +2 more
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JMJD3 is a histone H3K27 demethylase [PDF]
Cell Research, 2007 Histone methylation is an important epigenetic phenomenon that participates in a diverse array of cellular processes and has been found to be associated with cancer. Recent identification of several histone demethylases has proved that histone methylation is a reversible process.
Yang, Xiang +5 more
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eLife, 2017 Certain mutations affecting central metabolism cause accumulation of the oncometabolite D-2-hydroxyglutarate which promotes progression of certain tumors.
Ryan Janke +2 more
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Current Perspectives on Histone Demethylases [PDF]
Acta Biochimica et Biophysica Sinica, 2007 The posttranslational modification of histones plays an important role in chromatin regulation. Histone methylation influences constitutive heterochromatin, genomic imprinting, X-chromosome inactivation and gene transcription. Histone demethylase catalyzes the removal of methyl groups on lysine or arginine residues of histones.
Xiaoqing, Tian, Jingyuan, Fang
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Depletion of Histone Demethylase Jarid1A Resulting in Histone Hyperacetylation and Radiation Sensitivity Does Not Affect DNA Double-Strand Break Repair. [PDF]
PLoS ONE, 2016 Histone demethylases have recently gained interest as potential targets in cancer treatment and several histone demethylases have been implicated in the DNA damage response.
Corina Penterling +15 more
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Histone Demethylases in Colon Cancer [PDF]
Current Colorectal Cancer Reports, 2014 Cell growth and proliferation are controlled through different posttranslational modifications including demethylation, a process regulated by regulated by the demethylase enzymes. This review focuses on our current understanding of functional and therapeutic potentials of histone demethylases in colon cancer.
Santanu, Paul +5 more
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In Vitro Histone Demethylase Assay [PDF]
Cold Spring Harbor Protocols, 2010 INTRODUCTIONPost-translational modifications of histones play an important role in regulating chromatin dynamics and function. One of the modifications, methylation, occurs on both lysine and arginine residues, and methylation status defines the epigenetic program of a cell by determining chromatin structure and thereby regulating DNA-dependent ...
Yu-ichi, Tsukada, Keiichi I, Nakayama
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