Results 11 to 20 of about 19,155 (194)
Histone Demethylases in Cancer [PDF]
Current Pharmacology Reports, 2015 Epigenetic regulation, which involves with covalent modifications of DNA and the protein that bundles DNA, namely histones, is an exciting and variable phenomenon that affects normal cellular genetic character and contributes to human diseases. One key histone modification is methylation, regulated by methyl transferases and demethylases.
Satheesh Sainathan +2 more
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The role of histone demethylases in cancer therapy [PDF]
Molecular Oncology, 2012 Reversible histone methylation has emerged in the last few years as an important mechanism of epigenetic regulation. Histone methyltransferases and demethylases have been identified as contributing factors in the development of several diseases, especially cancer.
Martin Roatsch +2 more
exaly +4 more sources
Epigenetic Control and Cancer: The Potential of Histone Demethylases as Therapeutic Targets
Pharmaceuticals, 2012 The development of cancer involves an immense number of factors at the molecular level. These factors are associated principally with alterations in the epigenetic mechanisms that regulate gene expression profiles.
Fernando Lizcano, Lizcano Fernando
exaly +3 more sources
JmjC histone demethylases act as chromatin oxygen sensors [PDF]
Molecular & Cellular Oncology, 2019 Oxygen sensing is important in physiology but also in disease. We find that hypoxia (oxygen deficiency) triggers rapid and hypoxia-inducible factor (HIF)-independent histone methylation changes which are reversible upon reoxygenation.
Michael Batie, Sonia Rocha
doaj +2 more sources
Histone demethylases regulate adipocyte thermogenesis. [PDF]
Diabetol Int, 2018 Adipocytes play a pivotal role in the regulation of energy metabolism. While white adipocyte stores energy, brown adipocyte dissipates energy by producing heat. In addition, another type of heat-producing adipocyte, beige adipocyte, emerges in white adipose tissue in response to chronic coldness.
Inagaki T.
europepmc +4 more sources
The emerging role of histone demethylases in renal cell carcinoma [PDF]
Journal of Kidney Cancer and VHL, 2017 Renal cell carcinoma (RCC), the most common kidney cancer, is responsible for more than 100,000 deaths per year worldwide. The molecular mechanism of RCC is poorly understood.
Xiaoqiang Guo, Qiaoxia Zhang
doaj +2 more sources
Allele-Specific Inhibition of Histone Demethylases. [PDF]
Chembiochem, 2019 AbstractHistone demethylases play a critical role in mammalian gene expression by removing methyl groups from lysine residues in degree‐ and site‐specific manner. To specifically interrogate members and isoforms of this class of enzymes, we have developed demethylase variants with an expanded active site.
Wagner S +5 more
europepmc +4 more sources
Technology in Cancer Research and Treatment, 2020 Background & Aims: Methylation of lysines on histones, controlled by various methyltransferases and demethylases, is an important component of epigenetic modifications, and abnormal regulation of such enzymes serves as common events in hepatocellular ...
Guojiang Chen, Ziling Liu
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Relationship between histone demethylase LSD family and development and prognosis of gastric cancer
Frontiers in Immunology, 2023 Objectiveto elucidate the correlation between histone demethylase and gastric cancerResearch objecthistone demethylase and gastric cancerResultsAs one of the important regulatory mechanisms in molecular biology and epigenetics, histone modification plays
Liyan Dong +8 more
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The Discovery of Histone Demethylases [PDF]
Cold Spring Harbor Perspectives in Biology, 2013 Histone methylation is a key element of the eukaryotic epigenome. Since the discovery of the first histone demethylase (HDM) in 2004, more than 20 demethylases have been identified and characterized. They belong to either the LSD family or the JmjC family, demonstrating the reversibility of all methylation states at almost all major histone lysine ...
Yujiang Geno, Shi, Yuichi, Tsukada
openaire +3 more sources