Results 11 to 20 of about 27,890 (158)

Histone demethylases in autophagy and inflammation. [PDF]

Cell Commun Signal
Autophagy dysfunction is associated with changes in autophagy-related genes. Various factors are connected to autophagy, and the mechanism regulating autophagy is highly complicated. Epigenetic changes, such as aberrant expression of histone demethylase, are actively associated not only with oncogenesis but also with inflammatory responses.
Ma Y, Lv W, Guo Y, Yin T, Bai Y, Liu Z, Chen C, WenjuanYang, Feng J, Qian W, Tang R, Su Y, Shan S, Dong H, Bao Y, Qu L.   +15 more
europepmc   +4 more sources

Histone demethylases regulate adipocyte thermogenesis. [PDF]

Diabetol Int, 2018
Adipocytes play a pivotal role in the regulation of energy metabolism. While white adipocyte stores energy, brown adipocyte dissipates energy by producing heat. In addition, another type of heat-producing adipocyte, beige adipocyte, emerges in white adipose tissue in response to chronic coldness.
Inagaki T.
europepmc   +4 more sources

Histone Lysine Demethylase Inhibitors [PDF]

Cold Spring Harbor Perspectives in Medicine, 2016
The dynamic regulation of covalent modifications to histones is essential for maintaining genomic integrity and cell identity and is often compromised in cancer. Aberrant expression of histone lysine demethylases has been documented in many types of blood and solid tumors, and thus demethylases represent promising therapeutic targets.
Ashwini, Jambhekar, Jamie N, Anastas, Yang, Shi   +2 more
openaire   +2 more sources

Allele-Specific Inhibition of Histone Demethylases. [PDF]

Chembiochem, 2019
AbstractHistone demethylases play a critical role in mammalian gene expression by removing methyl groups from lysine residues in degree‐ and site‐specific manner. To specifically interrogate members and isoforms of this class of enzymes, we have developed demethylase variants with an expanded active site.
Wagner S, Waldman M, Arora S, Wang S, Scott V, Islam K.   +5 more
europepmc   +4 more sources

Histone Demethylase LSD1 Regulates Adipogenesis [PDF]

Journal of Biological Chemistry, 2010
Epigenetic mechanisms, in particular the enzymatic modification of histones, are a crucial element of cell differentiation, a regulated process that allows a precursor cell basically to turn into a different cell type while maintaining the same genetic equipment.
Melina M, Musri, Mari Carmen, Carmona, Felicia A, Hanzu, Perla, Kaliman, Ramon, Gomis, Marcelina, Párrizas   +5 more
openaire   +2 more sources

Current Perspectives on Histone Demethylases [PDF]

Acta Biochimica et Biophysica Sinica, 2007
The posttranslational modification of histones plays an important role in chromatin regulation. Histone methylation influences constitutive heterochromatin, genomic imprinting, X-chromosome inactivation and gene transcription. Histone demethylase catalyzes the removal of methyl groups on lysine or arginine residues of histones.
Xiaoqing, Tian, Jingyuan, Fang
openaire   +2 more sources

Histone Demethylases in Colon Cancer [PDF]

Current Colorectal Cancer Reports, 2014
Cell growth and proliferation are controlled through different posttranslational modifications including demethylation, a process regulated by regulated by the demethylase enzymes. This review focuses on our current understanding of functional and therapeutic potentials of histone demethylases in colon cancer.
Santanu, Paul, Satish, Ramalingam, Dharmalingam, Subramaniam, Joaquina, Baranda, Shrikant, Anant, Animesh, Dhar   +5 more
openaire   +2 more sources

The Discovery of Histone Demethylases [PDF]

Cold Spring Harbor Perspectives in Biology, 2013
Histone methylation is a key element of the eukaryotic epigenome. Since the discovery of the first histone demethylase (HDM) in 2004, more than 20 demethylases have been identified and characterized. They belong to either the LSD family or the JmjC family, demonstrating the reversibility of all methylation states at almost all major histone lysine ...
Yujiang Geno, Shi, Yuichi, Tsukada
openaire   +3 more sources

In Vitro Histone Demethylase Assay [PDF]

Cold Spring Harbor Protocols, 2010
INTRODUCTIONPost-translational modifications of histones play an important role in regulating chromatin dynamics and function. One of the modifications, methylation, occurs on both lysine and arginine residues, and methylation status defines the epigenetic program of a cell by determining chromatin structure and thereby regulating DNA-dependent ...
Yu-ichi, Tsukada, Keiichi I, Nakayama
openaire   +2 more sources

Human Histone Demethylase LSD1 Reads the Histone Code [PDF]

Journal of Biological Chemistry, 2005
Human histone demethylase LSD1 is a flavin-dependent amine oxidase that catalyzes the specific removal of methyl groups from mono- and dimethylated Lys4 of histone H3. The N-terminal tail of H3 is subject to various covalent modifications, and a fundamental question in LSD1 biology is how these epigenetic marks affect the demethylase activity.
F. Forneris, C. Binda, M.A. Vanoni, E. Battaglioli, A. Mattevi   +4 more
openaire   +4 more sources