Results 11 to 20 of about 19,208 (197)
JmjC histone demethylases act as chromatin oxygen sensors [PDF]
Molecular & Cellular Oncology, 2019 Oxygen sensing is important in physiology but also in disease. We find that hypoxia (oxygen deficiency) triggers rapid and hypoxia-inducible factor (HIF)-independent histone methylation changes which are reversible upon reoxygenation.
Michael Batie, Sonia Rocha
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Discovery and structural studies of histone demethylases
Frontiers in Epigenetics and EpigenomicsThe discovery and structural elucidation of histone demethylases represent a groundbreaking advancement in the field of epigenetics. Histone methylation, a critical chromatin modification, was long regarded as irreversible until the identification of ...
Longfei Peng +5 more
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The emerging role of histone demethylases in renal cell carcinoma [PDF]
Journal of Kidney Cancer and VHL, 2017 Renal cell carcinoma (RCC), the most common kidney cancer, is responsible for more than 100,000 deaths per year worldwide. The molecular mechanism of RCC is poorly understood.
Xiaoqiang Guo, Qiaoxia Zhang
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JmjC Family of Histone Demethylases Form Nuclear Condensates [PDF]
International Journal of Molecular Sciences, 2022 Marta Vicioso Mantis +2 more
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Histone Demethylases ELF6 and JMJ13 Antagonistically Regulate Self-Fertility in Arabidopsis [PDF]
Frontiers in Plant Science, 2021 Keyzor C +4 more
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Relationship between histone demethylase LSD family and development and prognosis of gastric cancer
Frontiers in Immunology, 2023 Objectiveto elucidate the correlation between histone demethylase and gastric cancerResearch objecthistone demethylase and gastric cancerResultsAs one of the important regulatory mechanisms in molecular biology and epigenetics, histone modification plays
Liyan Dong +8 more
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The Discovery of Histone Demethylases [PDF]
Cold Spring Harbor Perspectives in Biology, 2013 Histone methylation is a key element of the eukaryotic epigenome. Since the discovery of the first histone demethylase (HDM) in 2004, more than 20 demethylases have been identified and characterized. They belong to either the LSD family or the JmjC family, demonstrating the reversibility of all methylation states at almost all major histone lysine ...
Yujiang Geno, Shi, Yuichi, Tsukada
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Histone H4K20 Demethylation by Two hHR23 Proteins
Cell Reports, 2020 Summary: Histone methyl groups can be removed by demethylases. Although LSD1 and JmjC domain-containing proteins have been identified as histone demethylases, enzymes for many histone methylation states or sites are still unknown.
Xiongwen Cao +13 more
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Histone demethylase Jumonji D3 (JMJD3) as a tumor suppressor by regulating p53 protein nuclear stabilization. [PDF]
PLoS ONE, 2012 Histone methylation regulates normal stem cell fate decisions through a coordinated interplay between histone methyltransferases and demethylases at lineage specific genes.
Chibawanye I Ene +18 more
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Biomolecules, 2021 Histone methylation tightly regulates chromatin accessibility, transcription, proliferation, and cell differentiation, and its perturbation contributes to oncogenic reprogramming of cells.
Hans Felix Staehle +2 more
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