Results 61 to 70 of about 197,157 (312)

Disruption of Methionine Metabolism in Drosophila melanogaster Impacts Histone Methylation and Results in Loss of Viability

G3: Genes, Genomes, Genetics, 2016
Histone methylation levels, which are determined by the action of both histone demethylases and methyltransferases, impact multiple biological processes by affecting gene expression activity.
Mengying Liu, Valerie L. Barnes, Lori A. Pile   +2 more
doaj   +1 more source

Emerging roles of telomeric chromatin alterations in cancer [PDF]

, 2019
Telomeres, the nucleoprotein structures that cap the ends of eukaryotic chromosomes, play important and multiple roles in tumorigenesis. Functional telomeres need the establishment of a protective chromatin structure based on the interplay between the ...
Biroccio, Annamaria, Cacchione, Stefano, Rizzo, Angela   +2 more
core   +1 more source

Discovery and structural studies of histone demethylases

Frontiers in Epigenetics and Epigenomics
The discovery and structural elucidation of histone demethylases represent a groundbreaking advancement in the field of epigenetics. Histone methylation, a critical chromatin modification, was long regarded as irreversible until the identification of ...
Longfei Peng, Xinze Li, Hao Yang, Haonan Chen, Yue Yang, Shunfeng Peng   +5 more
doaj   +1 more source

Epigenetic Control and Cancer: The Potential of Histone Demethylases as Therapeutic Targets

Pharmaceuticals, 2012
The development of cancer involves an immense number of factors at the molecular level. These factors are associated principally with alterations in the epigenetic mechanisms that regulate gene expression profiles.
Jeison Garcia, Fernando Lizcano
doaj   +1 more source

Targeting histone methyltransferases and demethylases in clinical trials for cancer therapy [PDF]

, 2016
Drawing of Object No ...
Ludovica Morera, Michael Lübbert, Manfred Jung   +2 more
core   +1 more source

Histone demethylases in chromatin cross‐talks [PDF]

Biology of the Cell, 2011
The ‘histone code’ hypothesis states that chromatin‐based regulation of nuclear processes such as transcription is brought about by the combination of distinct modifications (histone marks) at specific loci. Its correct establishment involves chromatin cross‐talks, ensuring an ordered and concerted deposition/removal of a particular set of ...
Laure, Verrier, Marie, Vandromme, Didier, Trouche   +2 more
openaire   +2 more sources

Histone Demethylase Modulation: Epigenetic Strategy to Combat Cancer Progression

Epigenomes, 2023
Epigenetic modifications are heritable, reversible changes in histones or the DNA that control gene functions, being exogenous to the genomic sequence itself. Human diseases, particularly cancer, are frequently connected to epigenetic dysregulations. One
Rashmi Srivastava, Rubi Singh, Shaurya Jauhari, Niraj Lodhi, Rakesh Srivastava   +4 more
doaj   +1 more source

Hypoxia Promotes Resistance to EGFR Inhibition in NSCLC Cells via the Histone Demethylases, LSD1 and PLU-1

Molecular Cancer Research, 2018
The development of small-molecule tyrosine kinase inhibitors (TKI) specific for epidermal growth factor receptors (EGFR) with activating mutations has led to a new paradigm in the treatment of non–small cell lung cancer (NSCLC) patients.
Yuhong Lu, Yanfeng Liu, S. Oeck, P. Glazer   +3 more
semanticscholar   +1 more source

JMJD3 is a histone H3K27 demethylase [PDF]

Cell Research, 2007
Histone methylation is an important epigenetic phenomenon that participates in a diverse array of cellular processes and has been found to be associated with cancer. Recent identification of several histone demethylases has proved that histone methylation is a reversible process.
Yang, Xiang, Ziqi, Zhu, Gang, Han, Hanqing, Lin, Longyong, Xu, Charlie Degui, Chen   +5 more
openaire   +2 more sources

Quantitative high-throughput screening identifies 8-hydroxyquinolines as cell-active histone demethylase inhibitors.

PLoS ONE, 2010
BackgroundSmall molecule modulators of epigenetic processes are currently sought as basic probes for biochemical mechanisms, and as starting points for development of therapeutic agents.
Oliver N F King, Xuan Shirley Li, Masaaki Sakurai, Akane Kawamura, Nathan R Rose, Stanley S Ng, Amy M Quinn, Ganesha Rai, Bryan T Mott, Paul Beswick, Robert J Klose, Udo Oppermann, Ajit Jadhav, Tom D Heightman, David J Maloney, Christopher J Schofield, Anton Simeonov   +16 more
doaj   +1 more source