Methylation-Demethylation Dynamics: Implications of Changes in Acute Kidney Injury
Analytical Cellular Pathology, 2018 Over the years, the epigenetic landscape has grown increasingly complex. Until recently, methylation of DNA and histones was considered one of the most important epigenetic modifications.
Anubhav Chakraborty +1 more
doaj +1 more source
SETDB1 prevents TET2-dependent activation of IAP retroelements in naïve embryonic stem cells
Genome Biology, 2018 Background Endogenous retroviruses (ERVs), which are responsible for 10% of spontaneous mouse mutations, are kept under control via several epigenetic mechanisms. The H3K9 histone methyltransferase SETDB1 is essential for ERV repression in embryonic stem
Özgen Deniz +4 more
doaj +1 more source
Practitioner Review: Infant mental health meets cell and molecular biology – a look to the future
Journal of Child Psychology and Psychiatry, EarlyView.Background A major research effort in the past two decades has begun to illuminate how experience ‘gets under the skin’ – that is – the cellular and molecular processes that are associated with adversity and resilience. Methods We selectively review three areas of this research: epigenetics, especially DNA methylation, telomere length, and inflammatory
Charles H. Zeanah +3 more
wiley +1 more source
Journal of Integrative Plant Biology, EarlyView.The rice transcription factor genes NAC20 and NAC26 regulate grain filling and show allele‐specific maternal expression due to transposable element insertions and paternal hypermethylation in their 5' upstream regions. Geographical analyses showed that japonica varieties that originated at high latitudes carried these transposable elements.
Ming‐Wei Wu +9 more
wiley +1 more source
Suppression of Gluconeogenic Gene Expression by LSD1-Mediated Histone Demethylation
PLoS ONE, 2013 Aberrant gluconeogenic gene expression is associated with diabetes, glycogen storage disease, and liver cancer. However, little is known how these genes are regulated at the chromatin level. In this study, we investigated in HepG2 cells whether histone demethylation is a potential mechanism.
Pan, Dongning +2 more
openaire +5 more sources
Histone Demethylation Profiles in Nonalcoholic Fatty Liver Disease and Prognostic Values in Hepatocellular Carcinoma: A Bioinformatic Analysis. [PDF]
Curr Issues Mol Biol, 2023 Liu Y, Chen M.
europepmc +1 more source
Epigenetic Regulation in the Pathogenesis of Periodontitis
Journal of Periodontal Research, EarlyView.The aim of this narrative literature review was to identify epigenetic marks associated with periodontitis and to place them in a biological context. The literature was reviewed based on pre‐defined criteria. Cell type specific chromatin and mRNA modifications were included.
Henrik Dommisch +3 more
wiley +1 more source
The epigenetic control of E-box and Myc-dependent chromatin modifications regulate the licensing of lamin B2 origin during cell cycle [PDF]
, 2012 Recent genome-wide mapping of the mammalian replication origins has suggested the role of transcriptional regulatory elements in origin activation. However, the nature of chromatin modifications associated with such trans-factors or epigenetic marks ...
Kumar, V, Singh, AK, Swarnalatha, M
core +1 more source
New Phytologist, EarlyView.Summary Subject to an ever‐changing world, plants must respond to harmful conditions and environmental fluctuations. Their evolutionary success can be attributed to their plasticity in both perceiving and integrating these variations to facilitate adaptation.
Rory Osborne
wiley +1 more source
KDM6A missense variants hamper H3 histone demethylation in lung squamous cell carcinoma. [PDF]
Comput Struct Biotechnol J, 2022 Biagini T +9 more
europepmc +1 more source