Results 241 to 250 of about 60,846 (261)
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Neuroblastoma and Histone Demethylation
New England Journal of Medicine, 2018Histone Methylation in Neuroblastoma A recent study of inhibitors of histone demethylases in vitro and in an animal model of neuroblastoma underscores the potential of a new pharmacologic approach ...
Steven G, DuBois, Julie R, Park
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Histone demethylation and androgen-dependent transcription
Current Opinion in Genetics & Development, 2006Covalent modifications of histones play important roles in the regulation of chromatin dynamics and gene activity. Until recently, it was believed that methyl groups could not be removed from histones; as such, the discovery of the first demethylases opens a novel era in understanding how chromatin dynamic is regulated and shows that active ...
Metzger, Eric +2 more
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Enzymatic demethylation of calf thymus histones
Biochemical and Biophysical Research Communications, 1973Abstract Enzymatic demethylation of e-N-methyllysine residues of calf thymus histone has been investigated. Kidney contains the highest enzyme activity among the rat organs tested, and the enzyme activity is associated with the nuclear and mitocondrial fractions.
W K, Paik, S, Kim
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Histone Demethylation by Hydroxylation: Chemistry in Action
ACS Chemical Biology, 2006Histone methylation plays an essential role in epigenetic regulation and has been thought to be an irreversible and stable modification of histones. However, several enzymes have recently been discovered to demethylate mono- and dimethylated lysine residues of histone H3 as well as monomethylated arginines via either amine oxidation or deimination ...
Jessica, Schneider, Ali, Shilatifard
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8 Demethylation pathways for histone methyllysine residues
2006Histone lysine methylation is one of the posttranslational modifications involved in transcriptional regulation and chromatin remodeling. The first lysine specific histone demethylase (LSD1) has been recently discovered, whichrules out the hypothesis that histone methylation represents a permanent epigenetic mark.
FORNERIS, FEDERICO +4 more
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Histone demethylation and steroid receptor function in cancer
Molecular and Cellular Endocrinology, 2012Steroid receptors recruit various cofactors to form multi-protein complexes which locally alter chromatin structure and control DNA accessibility in order to regulate gene transcription. Some of these factors are enzymes that add or remove histone marks in the vicinity of regulatory regions of target genes.
Antje, Stratmann, Bernard, Haendler
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Control of histone demethylation by nuclear-localized α-ketoglutarate dehydrogenase
Science, 2023Methylations on nucleosomal histones play fundamental roles in regulating eukaryotic transcription. Jumonji C domain–containing histone demethylases (JMJs) dynamically control the level of histone methylations. However, how JMJ activity is generally regulated is unknown.
Fei Huang +7 more
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Asparagine starvation suppresses histone demethylation through iron depletion
2022AbstractNutrient availability can impact epigenome to modify gene expression and dictate cell fate decision (Etchegaray and Mostoslavsky, 2016; Kinnaird et al., 2016). α-ketoglutarate is an indispensable substrate for the Jumonji family of histone demethylases (JHDMs) mediating most of the cellular demethylation reactions on histone subunits ...
Jie Jiang +12 more
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Histone lysine methylation and demethylation pathways in cancer
Biochimica et Biophysica Acta (BBA) - Reviews on Cancer, 2011The genetic changes leading to the development of human cancer are accompanied by alterations in the structure and modification status of chromatin, which represent powerful regulatory mechanisms for gene expression and genome stability. These epigenetic alterations have sparked interest into deciphering the regulatory pathways and function of post ...
Radhika A, Varier, H T Marc, Timmers
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Phosphorylation of histone H3T6 by PKCβI controls demethylation at histone H3K4
Nature, 2010Demethylation at distinct lysine residues in histone H3 by lysine-specific demethylase 1 (LSD1) causes either gene repression or activation. As a component of co-repressor complexes, LSD1 contributes to target gene repression by removing mono- and dimethyl marks from lysine 4 of histone H3 (H3K4).
Metzger, Eric +14 more
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