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The Molecular Basis of Histone Demethylation
2017The methylation of lysine residues on histone tails--and their subsequent demethylation--is among some of the most important covalent post-translational modifications controlling gene expression. When gene expression goes awry, disease ensues and often this disease is some form of cancer.
John R. Horton +3 more
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DNA Demethylating Agents and Histone Deacetylase Inhibitors in Hematologic Malignancies
The Cancer Journal, 2007The pivotal role of aberrant promoter methylation in gene silencing and cancer development has fueled the interest in DNA methyltransferase inhibitors as novel anticancer drugs. Modulation of gene expression through targeting of epigenetic marks is one of the emerging and promising strategies that has demonstrated successful clinical outcome in ...
Tamer E, Fandy +2 more
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Histone demethylation tones down leukemia through innate immunity
Science ImmunologyHistone demethylation by PHF8 initiates innate immune signaling in acute myeloid leukemia, elucidating a novel therapeutic strategy.
Andre, Monteleone, Gabriel K, Griffin
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Histone demethylation by a family of JmjC domain-containing proteins
Nature, 2005Covalent modification of histones has an important role in regulating chromatin dynamics and transcription. Whereas most covalent histone modifications are reversible, until recently it was unknown whether methyl groups could be actively removed from histones.
Yu-ichi, Tsukada +6 more
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Demethylation pathways for histone methyllysine residues
2006Histone lysine methylation is one of the posttranslational modifications involved in transcriptional regulation and chromatin remodeling. The first lysine specific histone demethylase (LSD1) has been recently discovered, which rules out the hypothesis that histone methylation represents a permanent epigenetic mark.
F. Forneris +4 more
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[Histone methylation and demethylation--focusing on demethylation--].
Seikagaku. The Journal of Japanese Biochemical Society, 2007openaire +1 more source