Results 191 to 200 of about 181,554 (237)

CHIP mediates glucagon action on hepatic glucose production via regulating Smad3 ubiquitination

Diabetes, Obesity and Metabolism, EarlyView.
Abstract Aims Excessive hepatic glucose production (HGP) driven by glucagon contributes to hyperglycaemia in obesity and type 2 diabetes (T2D), yet the molecular mechanisms underlying this dysregulation remain incompletely defined. This study investigates the role of Smad3 signaling and its regulation by CHIP (Carboxy‐terminus of Hsc70‐interacting ...
Quan Pan, Weiqi Ai, Yunmei Chen, Zheng Shen, Wanbao Yang, Wen Jiang, Shaodong Guo   +6 more
wiley   +1 more source

The role of histone H3 leucine 126 in fine-tuning the copper reductase activity of nucleosomes. [PDF]

J Biol Chem
Tod NP, Vogelauer M, Cheng C, Karimian A, Schmollinger S, Camacho D, Kurdistani SK.   +6 more
europepmc   +1 more source

Cardioprotective effects of the extracellular chaperone clusterin in acute myocardial infarction

European Journal of Clinical Investigation, EarlyView.
In vivo, CLU−/− mice were more susceptible to acute myocardial infarction than CLU+/+ mice. Moreover, inflammation and histone levels were significantly increased in CLU−/− mice compared to CLU+/+ mice following ischemia/reperfusion. In vitro, CLU protects cardiomyocytes from histone‐ and/or hypoxia‐induced cell death.
Louwana Allawa, Antoine Poirier, Pascale Pignon, Justine Beaumont, Lucie Lebeau, Agnès Barbelivien, Thomas Bochaton, Céline Beauvillain, Daniel Henrion, Yves Delneste, Pascale Jeannin, Fabrice Prunier, Sophie Tamareille   +12 more
wiley   +1 more source

SHP2 as a primordial epigenetic enzyme expunges histone H3 pTyr-54 to amend androgen receptor homeostasis. [PDF]

Nat Commun
Chouhan S, Sridaran D, Weimholt C, Luo J, Li T, Hodgson MC, Santos LN, Le Sommer S, Fang B, Koomen JM, Seeliger M, Qu CK, Yart A, Kontaridis MI, Mahajan K, Mahajan NP.   +15 more
europepmc   +1 more source

Sensitization of Non‐M3 Acute Myeloid Leukemia Blasts to All‐Trans Retinoic Acid by the LSD1 Inhibitor Tranylcypromine: TRANSATRA Phase I Study

European Journal of Haematology, EarlyView.
ABSTRACT The treatment of elderly, nonfit acute myeloid leukemia (AML)/MDS patients with relapsed/refractory (R/R) disease remains challenging. As histone demethylase LSD1 (KDM1A) is a rational therapeutic target in AML, we conducted a phase I trial (“rolling‐six design”) with the LSD1 inhibitor tranylcypromine (TCP, dose levels [DL] 20, 40, 60, 80 mg ...
Michael Kruszewski, Claudia Schmoor, Tobias Berg, Usama‐Ur Rehman, Marcus Schittenhelm, Katharina Götze, Andrea Kündgen, Caroline Pabst, Tobias Ma, Anna Frey, Julia Stomper, Dietmar Pfeifer, Eric Metzger, Johannes Jung, Kevin Moschallski, Johanna Thomas, Gesine Bug, Justus Duyster, Manfred Jung, Roland Schüle, Ralph Wäsch, Olga Grishina, Michael Lübbert   +22 more
wiley   +1 more source

Cancer-associated Histone H3 N-terminal arginine mutations disrupt PRC2 activity and impair differentiation. [PDF]

Nat Commun
Nacev BA, Dabas Y, Paul MR, Pacheco C, Mitchener M, Perez Y, Fang Y, Soshnev AA, Barrows D, Carroll T, Socci ND, St Jean SC, Tiwari S, Gruss MJ, Monette S, Tap WD, Garcia BA, Muir T, Allis CD.   +18 more
europepmc   +1 more source

In vitro models of valproic acid to assess neurodevelopmental toxicity: A scoping review

Epilepsia, EarlyView.
Abstract Valproic acid (VPA) is a first‐line antiseizure medication (ASM) that is highly efficacious for treating generalized and focal epilepsy disorders. Unfortunately, due to its strong association with teratogenic effects culminating in fetal valproate spectrum disorder (FVSD), which may include neurocognitive and neurobehavioral deficits, the drug
Daniel Sandvik, Elena Vianca, Alison Anderson, Muhammad Shahid Javaid, Terence J. O'Brien, Ana Antonic‐Baker   +5 more
wiley   +1 more source

Retracted: The Early Diagnostic Efficacy of Serum Histone H3 in Rabbit Urosepsis Model. [PDF]

Biomed Res Int
International BR.
europepmc   +1 more source

Protective immune response against Rhodococcus equi: An innate immunity‐focused review

Equine Veterinary Journal, Volume 57, Issue 3, Page 563-586, May 2025.
Abstract Rhodococcus equi causes pyogranulomatous pneumonia in foals and immunocompromised people. Despite decades of research efforts, no vaccine is available against this common cause of disease and death in foals. The purpose of this narrative review is to summarise the current understanding of interactions between R. equi and the host innate immune
Bibiana Petri da Silveira, Noah D. Cohen, Sara D. Lawhon, Robert O. Watson, Angela I. Bordin   +4 more
wiley   +1 more source

DNA polymerase δ subunit Pol32 binds histone H3-H4 and couples nucleosome assembly with Okazaki fragment processing. [PDF]

Sci Adv
Shi G, Yang C, Wu J, Lei Y, Hu J, Feng J, Li Q.   +6 more
europepmc   +1 more source