Results 231 to 240 of about 196,399 (287)

Autoantibody signatures in children with celiac disease, juvenile idiopathic arthritis, and polyautoimmunity

JPGN Reports, EarlyView.
Abstract Objective To determine if multiplex autoantibody arrays can identify novel biomarker signatures in children with one or multiple autoimmune diseases (polyautoimmunity). Methods Plasma collected from children (18 years or younger) in the Boston Children's Hospital Precision Link Biobank for Health Discovery between January 2007 and June 2021 ...
Nan Du, Denis Chang, Madison Wong, Jay R. Thiagarajah, Erin Janssen, Lauren A. Henderson, Krishnan Raghunathan, Jocelyn A. Silvester   +7 more
wiley   +1 more source

Histone H3 Lysine 9 Acetylation Plays a Role in Adipogenesis of Periodontal Ligament-Derived Stem Cells. [PDF]

Epigenomes
Montero-Del-Toro JA, Serralta-Interian AA, Nic-Can GI, Lamas M, Rivera-Solís RA, Rodas-Junco BA.   +5 more
europepmc   +1 more source

Human Breast Milk‐Derived Exosomal FP671120.4 Inhibits Macrophage M1 Polarization via Modulating the ELAVL1/Nrf2 Axis in Sepsis‐Associated Liver Injury

The Kaohsiung Journal of Medical Sciences, EarlyView.
ABSTRACT Sepsis‐associated liver injury (SALI) plays a major role in aggravating disease progression and worsening prognosis in patients with sepsis. Macrophage polarization is a key factor in the modulation of SALI progression. Recent studies have shown that human breast milk‐derived exosomes (HBM‐Exos) regulate processes involved in macrophage ...
Zhao‐Bin Yang, Yi‐Bin Gao, Xiao‐Mei Cheng, Lu‐Zhen Qiu   +3 more
wiley   +1 more source

Histone H3 mutations and their impact on genome stability maintenance. [PDF]

Biochem Soc Trans
Caeiro LD, Verdun RE, Morey L.
europepmc   +1 more source

HOXA5 Suppresses NEK7‐Mediated Alveolar Epithelial Pyroptosis in Acute Lung Injury by Transcriptionally Inhibiting KAT2A

The Kaohsiung Journal of Medical Sciences, EarlyView.
ABSTRACT Alveolar epithelial cell pyroptosis exacerbates inflammation and tissue damage by releasing inflammatory mediators, thereby promoting the development of acute lung injury (ALI). However, the fundamental mechanism underlying alveolar epithelial cell pyroptosis in ALI has not yet been elucidated. Lipopolysaccharide (LPS) was used to simulate ALI
Lei Wang, Heng Fan, Qi Wang, Cheng‐Jie Jiang, Dan‐Hui Li, Ji‐Hui Ye   +5 more
wiley   +1 more source

Evaluation of Protein Ion Relative Ratio Quantification in Top-down Electrospray Ionization-Mass Spectrometry Using Site-Specific Acetylated Recombinant Histone H3 Proteoforms. [PDF]

J Am Soc Mass Spectrom
Lui KW, Ngai SM, Chan TF.
europepmc   +1 more source

Involvement of the miR‐128‐3p/KDM3A/NLRP3 Axis in High Glucose‐Induced Inflammatory Injury in Retinal Endothelial Cells

The Kaohsiung Journal of Medical Sciences, EarlyView.
ABSTRACT This study explores the regulatory mechanism of the miR‐128‐3p in diabetic retinopathy (DR)‐associated inflammatory injury. A cellular model of DR was established by inducing immortalized human retinal endothelial cells (IM‐HRECs) with high‐glucose (HG).
Wei‐Ming Wen, Jian‐Bo Feng, Yin‐Sheng Cai, Nan Lin, Fei Lv, Zhu‐Sheng Guo   +5 more
wiley   +1 more source

KDM4C inhibition blocks tumor growth in basal breast cancer by promoting cathepsin L-mediated histone H3 cleavage. [PDF]

Nat Genet
Li Z, Peluffo G, Stevens LE, Qiu X, Seehawer M, Tawawalla A, Huang XY, Egri SB, Raval S, McFadden M, D'Santos CS, Papachristou E, Kingston NL, Nishida J, Evans KE, Seo JH, Clement K, Temko D, Ekram M, Li R, Rees MG, Ronan MM, Roth JA, Simeonov A, Kales SC, Rai G, Lal-Nag M, Maloney DJ, Jadhav A, Michor F, Meissner A, Balko JM, Carroll JS, Freedman ML, Jaffe JD, Papanastasiou M, Long HW, Polyak K.   +37 more
europepmc   +1 more source

Role of ZNF652 in Regulating Hepatocellular Carcinoma Cell Proliferation and Apoptosis via the circRHOT1/SLC38A6 Axis

The Kaohsiung Journal of Medical Sciences, EarlyView.
ABSTRACT Hepatocellular carcinoma (HCC) is a heterogeneous malignancy characterized by high mortality rates. This article presents a discussion of the role of ZNF652 in HCC cell proliferation and apoptosis, thereby identifying a new target for HCC treatment. The expression levels of ZNF652, circRHOT1, and SLC38A6 in HCC and healthy cells were analyzed.
Kang Chen, Fei‐Hu Sun, Chen Fan, Wei Ding, Hao‐Huan Tang, Lei Sun, Wei‐Tao Wang, Wei‐Dong Wang   +7 more
wiley   +1 more source

The ortholog of human DNAJC9 promotes histone H3-H4 degradation and is counteracted by Asf1 in fission yeast. [PDF]

Nucleic Acids Res
Ding Y, Li J, Jiang HL, Suo F, Shao GC, Zhang XR, Dong MQ, Liu CP, Xu RM, Du LL.   +9 more
europepmc   +1 more source