Results 181 to 190 of about 257,789 (305)

Adss1–HDAC3 Interaction: A Novel Mechanism for Epigenetic Regulation of Metabolism in Adipose Tissue

iNew Medicine, EarlyView.
ABSTRACT Obesity and its related metabolic disorders have emerged as global public health challenges with underlying mechanisms involving an imbalance between energy storage and expenditure in the adipose tissue. In recent years, with the deepening research on adipose tissue metabolism, the cross talk between metabolic enzymes and epigenetic regulation
Jiarui Zhao, Jingjing Sun, Yan Lu, Ying Yang   +3 more
wiley   +1 more source

Human opsin restoration by histone methylation using methyltransferase fusion protein SETD7-dCas9. [PDF]

Mol Ther Nucleic Acids
Tran NL, Kang YE, Jeong H, Kim Y, Shin SC, Kim SH, Park B, Oh SJ.   +7 more
europepmc   +1 more source

Epileptic encephalopathy with spike‐and‐wave activation in sleep associated with Tatton–Brown–Rahman syndrome responsive to highly purified cannabidiol

Epileptic Disorders, EarlyView.
Anita N. Datta
wiley   +1 more source

N6‐Methyladenosine (m6A) in Liver Disease: Pathogenic Mechanisms and Therapeutic Potential

iNew Medicine, EarlyView.
ABSTRACT Accumulating evidence highlights the critical role of epigenetic modifications, particularly N6‐methyladenosine (m6A), in liver disease. As the most abundant RNA modification in eukaryotic cells, m6A is dynamically regulated by multicomponent m6A methyltransferases (e.g., METTL3 and METTL14), demethylases (FTO and ALKBH5), and m6A‐binding ...
Yingfen Chen, Ru Ya, Ziling Zhang, Siyue Dong, Seol Hee Park, Wonhyo Seo, Yong He   +6 more
wiley   +1 more source

SETD3 regulates Bcl-6 expression and Tfh differentiation in SLE CD4⁺ T cells by manipulating histone methylation and acetylation. [PDF]

Clin Epigenetics
Ding S, Xue S, Rao Y, Hu LX, Liao JY.
europepmc   +1 more source

SUMOylation regulates tumorigenesis and progression: Molecular mechanisms and therapeutic applications

Interdisciplinary Medicine, EarlyView.
SUMOylation, a dynamic post‐translational modification, acts as a master regulator at the heart of tumor malignancy. Our work delineates how the SUMOylation cycle—mediated by E1/E2/E3 enzymes and reversed by SENPs—orchestrates multiple hallmarks of cancer. The central pathway converges on three critical pathological axes: 1.
Yimao Wu, Zichang Chen, Yinting Hu, Gokhan Zengin, Qian Zhang, Meng‐Yao Li, Wenlong Sun   +6 more
wiley   +1 more source

Distinct classes of lamina-associated domains are defined by differential patterns of repressive histone methylation. [PDF]

Genome Res
Martin CJ, Oser EA, Nagarajan P, Popova LV, Sunkel BD, Stanton BZ, Parthun MR.   +6 more
europepmc   +1 more source

Insights into the Role of Histone Methylation in Brain Aging and Potential Therapeutic Interventions. [PDF]

Int J Mol Sci, 2023
Vitorakis N, Piperi C.
europepmc   +1 more source

Paternal Exposure to the Neonicotinoid Pesticide Clothianidin Alters Sperm MicroRNA Profiles in Mice and Intergenerationally Reduces Locomotor Activity in Male Offspring

Journal of Applied Toxicology, EarlyView.
ABSTRACT Accumulating evidence suggests that paternal environmental factors have epigenetic effects on sperm and influence offspring. Neonicotinoid pesticides (NNs), which are widely used around the world, are known to affect offspring phenotypes through maternal exposure in mice, but the effect of the paternal exposure remains unknown.
Makiko Ito, Tetsushi Hirano, Sarika Nunobiki, Ayano Yoshimoto, Yukako Hara, Yuya Ishida, Sakura Yonoichi, Youhei Mantani, Toshifumi Yokoyama, Yoshiaki Tabuchi, Yoshinori Ikenaka, Nobuhiko Hoshi   +11 more
wiley   +1 more source

Ectopic transcription due to inherited histone methylation may interfere with the ongoing function of differentiated neurons. [PDF]

Proc Natl Acad Sci U S A
Rodriguez JD, Reeves MN, Chavez SR, Wang HV, Chavez JZ, Rastogi R, Sun LI, Roberson MS, Preston EA, Massenburg Z, Cruz KN, Chadha MS, Hill EJ, Soares ML, Corces VG, Carpenter BS, Schmeichel KL, Murray JI, Katz DJ.   +18 more
europepmc   +1 more source