Results 221 to 230 of about 166,151 (260)

Reversing histone methylation

Nature, 2005
Histones package DNA, and post-translational modifications of histones can regulate access to DNA. Until recently, histone methylation-unlike all other histone modifications-was considered a permanent mark. The discovery of enzymes that reverse the methylation of lysines and arginines challenges our current thinking on the unique nature of histone ...
Andrew J, Bannister, Tony, Kouzarides
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Inhibitors of histone methylation

Chemico-Biological Interactions, 1974
Two classes of inhibitors of histone methyltransferase I from calf thymus are reported. High concentrations (≧ 10 mM) of various alkyl or aralkyl amines and polyamines were inhibitory to the enzyme. Spermine and spermidine were among the most potent compounds in this group.
M, Cory, D W, Henry, D L, Taylor, K J, Koskela   +3 more
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Histone Methylation: Recognizing the Methyl Mark

2003
Publisher Summary Histone N-terminal tails are subject to a variety of covalent modifications that ultimately affect chromatin structure. One such modification is N-methylation, which occurs on Lys (K) and Arg (R) amino acids. The enzymes performing these modifications are the histone N-methyl transferases (HMTs) that catalyze the transfer of a ...
Andrew J, Bannister, Tony, Kouzarides
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SET domains and histone methylation

Current Opinion in Structural Biology, 2003
The realisation that SET domains, which are found in numerous proteins involved in chromatin regulation, catalyse the methylation of lysine residues has led to intense interest in their cellular, biochemical and structural properties. The structures of five SET domain proteins have been reported over the past year. SET domains possess a novel fold, and
Bing, Xiao, Jonathan R, Wilson, Steven J, Gamblin   +2 more
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DNA and histone methylation in plants

Trends in Genetics, 2004
Heritable patterns of gene activity and gene silencing arise by the formation and the propagation of specific chromatin states that restrict or permit gene expression. In mammals and in plants, restrictive heterochromatin is associated with the hypermethylation of DNA at CG sites and with the specific modification of histones, such as the methylation ...
Tariq, Muhammad, Paszkowski, Jerzy
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The Generation and Recognition of Histone Methylation

2006
The posttranslational modification of histone proteins via methylation has important functions in gene activation, transcriptional silencing, establishment of chromatin states, and likely many aspects of DNA metabolism. The identification of numerous effector protein domains with the capability of binding methylated histones has significantly advanced ...
Michael S, Torok, Patrick A, Grant
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Targeting Histone Methylation in Cancer

The Cancer Journal, 2017
Abstract Most, if not all, human cancers exhibit altered epigenetic signatures that promote aberrant gene expression that contributes to cellular transformation. Historically, attempts to pharmacologically intervene in this process have focused on DNA methylation and histone acetylation.
Michael T, McCabe, Helai P, Mohammad, Olena, Barbash, Ryan G, Kruger   +3 more
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Posttranslational Modifications of Histones by Methylation

2004
Publisher Summary This chapter demonstrates that an RNA polymerase II elongation factor—the Paf1 complex—is required for the recruitment of histone methyltransferases to the elongating RNA polymerase and suggests that it is possible that modification by methylation may serve as a mark of transcriptional memory for transcribed genes.
Adam, Wood, Ali, Shilatifard
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DNA methylation, histone H3 methylation, and histone H4 acetylation in the genome of a crustacean

Genome, 2006
In this work, we used antibodies against histone H3 trimethylated at lysine 9 (H3K9m3); against histone H4 acetylated at lysines 5, 8, 12, and 16 (H4ac); and against DNA methylated at 5C cytosine (m5C) to study the presence and distribution of these markers in the genome of the isopod crustacean Asellus aquaticus.
Rita Barzotti, PELLICCIA, Franca, ROCCHI, Angela   +2 more
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The Sounds of Silence – Histone Deacetylation Meets hisTone Methylation

Genetica, 2003
The repression of gene activity and the maintenance of the repressed state are fundamental requirements of cell differentiation, ordered embryonic development and tissue integrity. Furthermore, large regions of the genome such as centromeres and telomeres have a structural function and have to be kept transcriptionally inactive to be functional.
Birgit, Czermin, Axel, Imhof
openaire   +2 more sources