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Histone Modification Therapy of Cancer
2010The state of modification of histone tails plays an important role in defining the accessibility of DNA for the transcription machinery and other regulatory factors. It has been extensively demonstrated that the posttranslational modifications of the histone tails, as well as modifications within the nucleosome domain, regulate the level of chromatin ...
Chiara, Biancotto +2 more
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2013
Histone posttranslational modifications (PTM) constitute one of the most important signaling pathways in the eukaryotic nucleus. In this chapter, we will discuss the molecular mechanisms by which histone PTM are deciphered by chromatin regulators and the functional outcomes of reading this signaling system.
Chun Ruan, Bing Li
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Histone posttranslational modifications (PTM) constitute one of the most important signaling pathways in the eukaryotic nucleus. In this chapter, we will discuss the molecular mechanisms by which histone PTM are deciphered by chromatin regulators and the functional outcomes of reading this signaling system.
Chun Ruan, Bing Li
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Global patterns of histone modifications
Current Opinion in Genetics & Development, 2007Histones, the proteins that package eukaryotic genomes into chromatin, are subject to a huge number and variety of covalent modifications. In the past few years, genomic technologies such as microarray hybridization have been applied to the study of histone modifications. These studies shed significant light on the role of covalent modifications in DNA-
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Histone Modifications in Corepressor Functions
2004Publisher Summary This chapter emphasizes histone modifications in corepressor functions. Histone modifications play a regulatory role in gene expression by altering higher order chromatin structures and by providing docking sites for non-histone regulatory proteins. Many corepressor complexes contain or recruit histone-modifying activities.
Judith K, Davie, Sharon Y R, Dent
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2017
There are a lot of histone modifications other than methylation, many of which are known to be dysregulated in cancer cells. This chapter briefly introduces typical histone modifications associated with cancer, and then provides an overview of the current understanding of histone acetylation.
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There are a lot of histone modifications other than methylation, many of which are known to be dysregulated in cancer cells. This chapter briefly introduces typical histone modifications associated with cancer, and then provides an overview of the current understanding of histone acetylation.
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Histone Posttranslational Modifications in Schizophrenia
2017Schizophrenia is a complex neuropsychiatric disorder with high heritability; however, family and twin studies have indicated that environmental factors also play important roles in the etiology of disease. Environmental triggers exert their influence on behavior via epigenetic mechanisms.
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