Results 241 to 250 of about 289,022 (302)

Cancer‐Associated Fibroblasts Promote Tumor Immunosuppression in Hepatocellular Carcinoma via the NNMT‐ANGPTL4 Axis

Advanced Science, EarlyView.
ABSTRACT Background & Aims: Cancer‐associated fibroblasts (CAFs) drive immunosuppression in hepatocellular carcinoma (HCC). However, their metabolic regulation remains poorly defined. We investigated the role of nicotinamide N‐methyltransferase (NNMT) in CAFs. Approach & Results: High NNMT expression in CAF tissues was confirmed by western blotting and
Shounan Lu, Shanjia Ke, Hongjun Yu, Zhanzhi Meng, Miaoyu Bai, Yanan Xu, Hui Zhu, Jinwen Yang, Baolin Qian, Bing Yin, Chaoqun Wang, Zhigang Feng, Zhongyu Li, Yongzhi Zhou, Zihao Li, Xinglong Li, Yongliang Hua, Yao Fu, Wei Tang, Yaohua Wu, Yong Ma   +20 more
wiley   +1 more source

Extracellular Vesicle‐Transferred ATP‐Citrate Lyase Induces Monocyte Differentiation Toward Tumor‐Associated Macrophages and Fuels Hepatocellular Carcinoma Progression

Advanced Science, EarlyView.
Hepatocellular carcinoma (HCC)‐derived extracellular vesicles (EVs) enrich the metabolic enzyme ATP‐citrate lyase (ACLY). EV‐transferred ACLY enhances palmitate biosynthesis, increases the S‐palmitoylation and stability of multiple immune checkpoint proteins, augments the cellular immunosuppressive activity, and ultimately accelerates the malignant ...
Zhijun Liu, Haihong Lai, Qing Yang, Chaoyue Zhang, Bin Jia, Qiyi Chen, Yuling Deng, Fen Cao, Yuyu You, Zhe Li, Dongming Kuang, Bo Li   +11 more
wiley   +1 more source

Integration of histone modification-based risk signature with drug sensitivity analysis reveals novel therapeutic strategies for lower-grade glioma. [PDF]

Front Pharmacol
Wang J, Yan S.
europepmc   +1 more source

Lactylation: the novel histone modification influence on gene expression, protein function, and disease. [PDF]

Clin Epigenetics
Hu Y, He Z, Li Z, Wang Y, Wu N, Sun H, Zhou Z, Hu Q, Cong X.   +8 more
europepmc   +1 more source

Evaluating histone modification analysis of individual preimplantation embryos. [PDF]

BMC Genomics
Zeng Y, Hoshino Y, Susami K, Honda S, Minami N, Ikeda S.   +5 more
europepmc   +1 more source

Dynamic histone modification signatures coordinate developmental programs in strawberry fruit ripening. [PDF]

Hortic Res
Pan Q, Guo S, Ding J, Zhou Y, Huang X, Qi Q, Wang F, Wu H, Li Y, Gu T.   +9 more
europepmc   +1 more source

A-Z of Epigenetic Readers: Targeting Alternative Splicing and Histone Modification Variants in Cancer. [PDF]

Cancers (Basel)
Mohan N, Dashwood RH, Rajendran P.
europepmc   +1 more source

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Histones and Their Modification

Critical Reviews in Biochemistry, 1986
Histones constitute the protein core around which DNA is coiled to form the basic structural unit of the chromosome known as the nucleosome. Because of the large amount of new histone needed during chromosome replication, the synthesis of histone and DNA is regulated in a complex manner.
R S, Wu, H T, Panusz, C L, Hatch, W M, Bonner   +3 more
openaire   +2 more sources

Histone Variants and Histone Modifications in Neurogenesis

Trends in Cell Biology, 2020
During embryonic brain development, neurogenesis requires the orchestration of gene expression to regulate neural stem cell (NSC) fate specification. Epigenetic regulation with specific emphasis on the modes of histone variants and histone post-translational modifications are involved in interactive gene regulation of central nervous system (CNS ...
Mengtian Zhang, Jinyue Zhao, Yuqing Lv, Wenwen Wang, Chao Feng, Wenzheng Zou, Libo Su, Jianwei Jiao   +7 more
openaire   +2 more sources