Results 231 to 240 of about 190,855 (259)

Detecting Histone Modifications in Plants

2014
Histone modifications play an essential role in chromatin-associated processes including gene regulation and epigenetic inheritance. It is therefore very important to quantitatively analyze histone modifications at both the single gene and whole genome level.
Song, J., Rutjens, B., Dean, C.
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Histone modifications in development

Development
ABSTRACT In eukaryotic cells, the genetic material is organized into chromatin, which consists mainly of DNA, histones and chromatin-associated proteins. An important regulator of chromatin structure and function are histone post-translational modifications, which can shape gene expression patterns and control the epigenetic landscape ...
Yu-Hao Liu, Robert Schneider
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Histone variants and histone modifications: A structural perspective

Biochemistry and Cell Biology, 2001
In this review, we briefly analyze the current state of knowledge on histone variants and their posttranslational modifications. We place special emphasis on the description of the structural component(s) defining and determining their functional role. The information available indicates that this histone "variability" may operate at different levels:
J, Ausió, D W, Abbott, X, Wang, S C, Moore   +3 more
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The language of covalent histone modifications

Nature, 2000
Histone proteins and the nucleosomes they form with DNA are the fundamental building blocks of eukaryotic chromatin. A diverse array of post-translational modifications that often occur on tail domains of these proteins has been well documented. Although the function of these highly conserved modifications has remained elusive, converging biochemical ...
B D, Strahl, C D, Allis
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Histone Modification Therapy of Cancer

2010
The state of modification of histone tails plays an important role in defining the accessibility of DNA for the transcription machinery and other regulatory factors. It has been extensively demonstrated that the posttranslational modifications of the histone tails, as well as modifications within the nucleosome domain, regulate the level of chromatin ...
Chiara, Biancotto, Gianmaria, Frigè, Saverio, Minucci   +2 more
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Functional consequences of histone modifications

Current Opinion in Genetics & Development, 2003
Covalent modifications of the histone proteins have well-known roles in gene expression. Experiments reported during the past year have extended this paradigm to include roles for histone acetylation and phosphorylation in DNA double-strand break repair.
Masayoshi, Iizuka, M Mitchell, Smith
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Histone interactions, histone modifications and chromatin structure

Philosophical Transactions of the Royal Society of London. B, Biological Sciences, 1978
Abstract A subunit structure for chromatin is now well established (Hewish & Burgoyne 1973; Burgoyne, Hewish & Hobbs 1974; Olins & Olins 1973, 1974; Woodcock 1973; Rill & Van Holde 1973; Kornberg 1974; Baldwin, Boseley, Bradbury & Ibel 1975; Oudet, Gross-Bellard & Chambon 1975)* Nuclease digestion of chromatin ...
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Histone Modifications in Corepressor Functions

2004
Publisher Summary This chapter emphasizes histone modifications in corepressor functions. Histone modifications play a regulatory role in gene expression by altering higher order chromatin structures and by providing docking sites for non-histone regulatory proteins. Many corepressor complexes contain or recruit histone-modifying activities.
Judith K, Davie, Sharon Y R, Dent
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Global patterns of histone modifications

Current Opinion in Genetics & Development, 2007
Histones, the proteins that package eukaryotic genomes into chromatin, are subject to a huge number and variety of covalent modifications. In the past few years, genomic technologies such as microarray hybridization have been applied to the study of histone modifications. These studies shed significant light on the role of covalent modifications in DNA-
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Histone Modification of Colorectal Cancer by Natural Products

Pharmaceuticals, 2023
Da Liu, Zijun Geng
exaly