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Lactylation: the novel histone modification influence on gene expression, protein function, and disease. [PDF]
Clin EpigeneticsHu Y +8 more
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Histones and Their Modification
Critical Reviews in Biochemistry, 1986Histones constitute the protein core around which DNA is coiled to form the basic structural unit of the chromosome known as the nucleosome. Because of the large amount of new histone needed during chromosome replication, the synthesis of histone and DNA is regulated in a complex manner.
R S, Wu +3 more
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The analysis of histone modifications
Biochimica et Biophysica Acta (BBA) - Proteins and Proteomics, 2006The biological function of many proteins is often regulated through posttranslational modifications (PTMs). Frequently different modifications influence each other and lead to an intricate network of interdependent modification patterns that affect protein-protein interactions, enzymatic activities and sub-cellular localizations.
Ana, Villar-Garea, Axel, Imhof
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Histone Variants and Histone Modifications in Neurogenesis
Trends in Cell Biology, 2020During embryonic brain development, neurogenesis requires the orchestration of gene expression to regulate neural stem cell (NSC) fate specification. Epigenetic regulation with specific emphasis on the modes of histone variants and histone post-translational modifications are involved in interactive gene regulation of central nervous system (CNS ...
Mengtian Zhang +7 more
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Overview of Histone Modification
2020Epigenetics is the epi-information beyond the DNA sequence that can be inherited from parents to offspring. From years of studies, people have found that histone modifications, DNA methylation, and RNA-based mechanism are the main means of epigenetic control. In this chapter, we will focus on the general introductions of epigenetics, which is important
Yanjun, Zhang +7 more
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Histone modifications in the brain
Neurochemistry International, 2007Chromatin remodelling, including histone modifications has been recognized to play a central role in the regulation of gene expression. Histone modifications are mostly based on studies in cell culture systems in vitro. Recent evidence suggests that histone modifications are actively involved in activity-dependent neural plasticity via regulation of ...
Hideo, Taniura +2 more
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The modification and variants of histone
Molecular Biology, 2007The modification of histone plays a crucial role in regulating chromatin states that conserve transcription programs and provide a mechanism for chromatin states to be maintained as cells proliferate. A large number of factors and protein complexes are now known to be involved in regulating the dynamic states of the modification and variants of histone.
Changjun, Mu +2 more
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Control of histone modifications
Journal of Cellular Biochemistry, 1999A role for histone modifications in transcription processes and the remodeling of chromatin structure has been established. This review highlights the recent advances made in studies on histone acetyltransferases, histone deacetylases, histone kinases, and protein phosphatases, as well as their roles in transcriptional activation and repression ...
J R, Davie, V A, Spencer
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Histone Modifications and Cancer
2010It is now widely recognized that epigenetic events are important mechanisms underlying cancer development and progression. Epigenetic information in chromatin includes covalent modifications (such as acetylation, methylation, phosphorylation, and ubiquitination) of core nucleosomal proteins (histones).
Carla, Sawan, Zdenko, Herceg
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