Cryo-EM of nucleosome core particle interactions in trans
Scientific Reports, 2018 Nucleosomes, the basic unit of chromatin, are repetitively spaced along DNA and regulate genome expression and maintenance. The long linear chromatin molecule is extensively condensed to fit DNA inside the nucleus.
Silvija Bilokapic +2 more
doaj +1 more source
Chromatin—a global buffer for eukaryotic gene control
AIMS Biophysics, 2015 Most of eukaryotic DNA is embedded into nucleosome arrays formed by DNA wrapped around a core histone octamer. Nucleosome is a fundamental repeating unit of chromatin guarding access to the genetic information.
Yuri M. Moshkin
doaj +1 more source
An advanced coarse-grained nucleosome core particle model for computer simulations of nucleosome-nucleosome interactions under varying ionic conditions. [PDF]
PLoS ONE, 2013 In the eukaryotic cell nucleus, DNA exists as chromatin, a compact but dynamic complex with histone proteins. The first level of DNA organization is the linear array of nucleosome core particles (NCPs).
Yanping Fan +3 more
doaj +1 more source
Epigenetic Regulation in the Pathogenesis of Renal Inflammation: Insights and Therapeutic Potentials
iNew Medicine, EarlyView.ABSTRACT Renal inflammation is a common pathological process in various kidney diseases, often initiated by factors such as toxins, ischemia, or autoimmune reactions. This inflammatory response can result in structural damage and a rapid decline in renal function.
Yu‐Hang Dong +5 more
wiley +1 more source
An organometallic compound which exhibits a DNA topology-dependent one-stranded intercalation mode [PDF]
, 2016 Understanding how small molecules interact with DNA is essential since it underlies a multitude of pathological conditions and therapeutic interventions.
Adhireksan +16 more
core +2 more sources
Chromatin Stability at Low Concentration Depends on Histone Octamer Saturation Levels [PDF]
Biophysical Journal, 2009 Studies on the stability of nucleosome core particles as a function of concentration have indicated a lower limit of approximately 5 ng/microL, below which the complexes start to spontaneously destabilize. Until recently little information was available on the effect of low concentration on chromatin.
Hagerman, Thomas A. +5 more
openaire +2 more sources
Intrinsic specificity of a ‘core’ TIP60 acetyltransferase complex in Drosophila
The FEBS Journal, EarlyView.The intrinsic substrate selectivity of the Drosophila TIP60‐core acetyltransferase was determined using synthetic nucleosome arrays. Targeted mass spectrometry revealed site‐specific acetylation of histones H2A, H2A.V, and H4, uncovering distinct acetylation rates and patterns across individual lysines.
Silke Krause +5 more
wiley +1 more source
MedComm – Oncology, Volume 5, Issue 1, March 2026.Ageing acts as a double‐edged sword in cancer. In the elderly, open chromatin, immunosenescence, and chronic inflammation drive SASP (IL‐6, MMPs), MDSC accumulation and T‐cell suppression, fostering tumor‐promoting microenvironments and limited therapeutic benefit.
Qi Wang +7 more
wiley +1 more source
Nickel binding sites in histone proteins [PDF]
, 2012 Nickel compounds are well known as human carcinogens, though the molecular events that are responsible for this are not well understood. It has been proposed that a crucial element in the mechanism of carcinogenesis is the binding of Ni(II) ions within
Medici, Serenella +3 more
core
Characterization of the histone methyltransferase PRDM9 using biochemical, biophysical and chemical biology techniques [PDF]
, 2014 PRDM proteins have emerged as important regulators of disease and developmental processes. To gain insight into the mechanistic actions of the PRDM family, we have performed comprehensive characterization of a prototype member protein, the histone ...
Alvin Hung +55 more
core +1 more source