Results 101 to 110 of about 186,634 (241)

Binding of NF-κB to nucleosomes: effect of translational positioning, nucleosome remodeling and linker histone H1. [PDF]

PLoS Genetics, 2013
NF-κB is a key transcription factor regulating the expression of inflammatory responsive genes. How NF-κB binds to naked DNA templates is well documented, but how it interacts with chromatin is far from being clear. Here we used a combination of UV laser
Imtiaz Nisar Lone, Manu Shubhdarshan Shukla, John Lalith Charles Richard, Zahary Yordanov Peshev, Stefan Dimitrov, Dimitar Angelov   +5 more
doaj   +1 more source

Structure of an Intranucleosomal DNA Loop That Senses DNA Damage during Transcription

Cells, 2022
Transcription through chromatin by RNA polymerase II (Pol II) is accompanied by the formation of small intranucleosomal DNA loops containing the enzyme (i-loops) that are involved in survival of core histones on the DNA and arrest of Pol II during the ...
Nadezhda S. Gerasimova, Olesya I. Volokh, Nikolay A. Pestov, Grigory A. Armeev, Mikhail P. Kirpichnikov, Alexey K. Shaytan, Olga S. Sokolova, Vasily M. Studitsky   +7 more
doaj   +1 more source

Changes in nucleosome occupancy occur in a chromosome specific manner

Genomics Data, 2014
In the eukaryotic nucleus, DNA is packaged into chromatin. The fundamental subunit of chromatin is the nucleosome, DNA is wrapped 1.6 times around a histone octamer core.
Brittany S. Sexton, Brooke R. Druliner, Denis Avey, Fanxiu Zhu, Jonathan H. Dennis   +4 more
doaj   +1 more source

A Pan‐TE Map Reveals the Important Role of Transposable Elements in Gene Expression and Phenotypic Diversity in 2,311 Rapeseed Accessions

Advanced Science, Volume 13, Issue 4, 19 January 2026.
This study presents the first pan‐transposable element (TE) atlas in rapeseed, profiling over 8 million TEs across 2311 accessions. Integrative analyses reveal that TEs broadly shape gene expression through diverse regulatory mechanisms, with key insertions in BnaA03.FLC and BnaA09.CYP78A9 linked to flowering time and silique development.
Zhiquan Yang, Haiyan Fan, Yifan Chen, Jiawei Li, Minjian Chen, Yingying Tan, Liang Guo, Jintao Li, Kede Liu, Qing‐Yong Yang   +9 more
wiley   +1 more source

HP1 reshapes nucleosome core to promote phase separation of heterochromatin [PDF]

, 2019
Heterochromatin affects genome function at many levels. It enables heritable gene repression, maintains chromosome integrity and provides mechanical rigidity to the nucleus1,2.
Burlingame, AL, Dharmarajan, V, Griffin, PR, Gross, JD, Narlikar, GJ, Pascal, BD, Sanulli, S, Tibble, RW, Trnka, MJ   +8 more
core  

Polymer reptation and nucleosome repositioning

, 2001
We consider how beads can diffuse along a chain that wraps them, without becoming displaced from the chain; our proposed mechanism is analogous to the reptation of "stored length" in more familiar situations of polymer dynamics. The problem arises in the
D. Keller, G. Meersseman, H. Schiessel, H. Schiessel, J. F. Marko, J. Widom, J. Widom, J. Widom, K. J. Polach, K. J. Polach, K. Luger, P. G. de Gennes, R. D. Kornberg, R. F. Bruinsma, S. A. Sukhishvili, S. Pennings, V. M. Studitsky, W. M. Gelbart, Y. Lorch   +18 more
core   +2 more sources

Structure, localization and histone binding properties of nuclear-associated nucleosome assembly protein from Plasmodium falciparum

Malaria Journal, 2010
Background Nucleosome assembly proteins (NAPs) are histone chaperones that are crucial for the shuttling and incorporation of histones into nucleosomes.
Maier Alexander G, Brown Monica, Rug Melanie, Jain SK, Belrhali Hassan, Yogavel Manickam, Kumar Anuj, Gill Jasmita, Sharma Amit   +8 more
doaj   +1 more source

Advances and Applications of Spatial Proteomics: From Organellar Maps to Clinical Translation

ChemBioChem, Volume 27, Issue 1, January 2026.
Spatial proteomics provides high‐resolution maps of protein localization and trafficking by combining advanced mass spectrometry with complementary imaging and computational tools. Emerging low‐input and automated workflows are expanding its applicability to challenging clinical samples, supporting mechanistic disease research and biomarker discovery ...
Chiara Bernardini, Maike Däther, Franziska R. Traube   +2 more
wiley   +1 more source

Accessibility of promoter DNA is not the primary determinant of chromatin-mediated gene regulation [PDF]

, 2019
DNA accessibility is thought to be of major importance in regulating gene expression. We test this hypothesis using a restriction enzyme as a probe of chromatin structure and as a proxy for transcription factors.
Chereji, Razvan V., Clark, David, Eriksson, Peter R., Ocampo, Josefina, Prajapati, Hemant Kumar   +4 more
core   +1 more source

The Histone Octamer Is Invisible When NF-κB Binds to the Nucleosome [PDF]

Journal of Biological Chemistry, 2004
The transcription factor NF-kappaB is involved in the transcriptional control of more than 150 genes, but the way it acts at the level of nucleosomal templates is not known. Here we report on a study examining the interaction of NF-kappaB p50 with its DNA recognition sequence in a positioned nucleosome.
Angelov, Dimitar, Lenouvel, François, Hans, Fabienne, Müller, Christoph, Bouvet, Philippe, Bednar, Jan, Moudrianakis, Evangelos, Cadet, Jean, Dimitrov, Stefan   +8 more
openaire   +6 more sources