Results 111 to 120 of about 186,634 (241)

Oocyte Age‐Dependent DNA Damage Can Be Reverted by the DNA Repair Competent Karyoplasm of Young Oocytes

Aging Cell, Volume 25, Issue 1, January 2026.
As females age, oocyte chromosomal aberrations and DNA damage increase in frequency; this condition is believed to be irreversible. By exposing the aged oocyte nuclei to nuclear factors from young oocytes, the negative effects can be effectively suppressed, restoring their developmental competence. ABSTRACT Mammalian fully grown oocytes are believed to
Nataliia Dudko, Tereza Ilcikova, Natalie Novotna, Marta Czernik, Pasqualino Loi, Josef Fulka Jr., Pritha Bhattacharjee, Raffaella Santoro, Helena Fulka   +8 more
wiley   +1 more source

Regulation of the nucleosome repeat length in vivo by the DNA sequence, protein concentrations and long-range interactions. [PDF]

, 2014
The nucleosome repeat length (NRL) is an integral chromatin property important for its biological functions. Recent experiments revealed several conflicting trends of the NRL dependence on the concentrations of histones and other architectural chromatin ...
Beshnova, Daria A, Cherstvy, Andrey G, Teif, Vladimir B, Vainshtein, Yevhen   +3 more
core   +2 more sources

Nucleosomal DNA unwinding pathway through canonical and non-canonical histone disassembly

Communications Biology
The nucleosome including H2A.B, a mammalian-specific H2A variant, plays pivotal roles in spermatogenesis, embryogenesis, and oncogenesis, indicating unique involvement in transcriptional regulation distinct from canonical H2A nucleosomes.
Hikaru Nozawa, Fritz Nagae, Satoshi Ogihara, Rina Hirano, Hirohito Yamazaki, Ryo Iizuka, Munetaka Akatsu, Tomoya Kujirai, Shoji Takada, Hitoshi Kurumizaka, Sotaro Uemura   +10 more
doaj   +1 more source

Sequence-dependent nucleosome sliding in rotation-coupled and uncoupled modes revealed by molecular simulations. [PDF]

PLoS Computational Biology, 2017
While nucleosome positioning on eukaryotic genome play important roles for genetic regulation, molecular mechanisms of nucleosome positioning and sliding along DNA are not well understood.
Toru Niina, Giovanni B Brandani, Cheng Tan, Shoji Takada   +3 more
doaj   +1 more source

The role of UPR‐related long noncoding RNAs in development of endocrine resistance in breast cancer

International Journal of Cancer, Volume 157, Issue 12, Page 2434-2446, 15 December 2025.
Abstract Breast cancer patients who express estrogen receptor α (ER) typically receive endocrine therapy as a first‐line treatment. Most ER‐positive breast cancer patients initially respond to endocrine therapy, but up to 40% of patients develop resistance over time, and the main mechanism is aberrant activation of ER signaling pathways.
Wen Liu, Sahil Gupta, Sanjeev Gupta
wiley   +1 more source

High-throughput sequencing reveals a simple model of nucleosome energetics

, 2010
We use nucleosome maps obtained by high-throughput sequencing to study sequence specificity of intrinsic histone-DNA interactions. In contrast with previous approaches, we employ an analogy between a classical one-dimensional fluid of finite-size ...
A. V. Morozov, Adams, D. Tolkunov, Deckert, Fedor, Felsenfeld, Field, G. Locke, Horz, Ioshikhes, Jenuwein, K. Struhl, Kaplan, Kornberg, Lee, Mavrich, Miller, Richmond, Segal, Sekinger, Tillo, Tolstorukov, Wang, Widom, Wingert, Yuan, Z. Moqtaderi   +26 more
core   +1 more source

Activation of the U2 snRNA promoter by the octamer motif defines a new class of RNA polymerase II enhancer elements [PDF]

, 1988
The recent discovery that the activation domains of transcriptional activators (e.g., GAL4) from a number of species are interchangeable has led to the concept of a general mechanism for activation of RNA polymerase II genes.
Grossniklaus, U., Hernandez, N., Herr, W., Tanaka, M.   +3 more
core   +1 more source

Genome-wide mapping and cryo-EM structural analyses of the overlapping tri-nucleosome composed of hexasome-hexasome-octasome moieties

Communications Biology
The nucleosome is a fundamental unit of chromatin in which about 150 base pairs of DNA are wrapped around a histone octamer. The overlapping di-nucleosome has been proposed as a product of chromatin remodeling around the transcription start site, and ...
Masahiro Nishimura, Takeru Fujii, Hiroki Tanaka, Kazumitsu Maehara, Ken Morishima, Masahiro Shimizu, Yuki Kobayashi, Kayo Nozawa, Yoshimasa Takizawa, Masaaki Sugiyama, Yasuyuki Ohkawa, Hitoshi Kurumizaka   +11 more
doaj   +1 more source

Single‐Cell Nucleus Extraction with Cellular Indexing

Advanced Science, Volume 12, Issue 46, December 11, 2025.
VacTrap is a multilayer, high‐throughput microfluidic system that isolates and spatially indexes single nuclei from hundreds of cells within minutes. Using dissolvable hydrogel trapdoors triggered by chemical and vacuum actuation, VacTrap synchronously transfers nuclei while preserving spatial links to parent cells.
Trinh Lam, Ana Esmeralda Gomez Martinez, Alison Su, Anna Fomitcheva‐Khartchenko, Xin Wang, Md Nazibul Islam, Paul Lum, Amy Elizabeth Herr   +7 more
wiley   +1 more source

Regulating repression : roles for the Sir4 N-terminus in linker DNA protection and stabilization of epigenetic states [PDF]

, 2012
The Gasser laboratory is supported by the Novartis Research Foundation and the EU training network Nucleosome 4D. SK was supported by an EMBO long-term fellowship, a Schrodinger fellowship from the FWF, and the Swiss SystemsX.ch initiative/C-CINA; HCF by
Ferreira, Helder C., Gasser, Susan M., Kueng, Stephanie, Oppikofer, Mariano, Roberts, Emma, Roloff, Tim-Christoph, Sack, Ragna, Tsai, Chinyen, Tsai-Pflugfelder, Monika   +8 more
core   +4 more sources