Results 121 to 130 of about 186,634 (241)
Curcumin's Therapeutic Potential in Ovarian Cancer: Current Insights and Future Perspectives
Food Science &Nutrition, Volume 13, Issue 12, December 2025.This review provides an overview of ovarian cancer, examines curcumin's emerging role in its treatment, identifies existing research gaps, and outlines a roadmap for future studies aimed at fully exploring curcumin's therapeutic potential in the management of ovarian cancer.
Smirnova Elena +7 more
wiley +1 more source
MedComm – Future Medicine, Volume 4, Issue 4, December 2025.Air pollution, a major global health hazard, contributes to asthma, chronic obstructive pulmonary disease, pulmonary fibrosis, and lung cancer via four core epigenetic pathways (DNA/RNA methylation, noncoding RNAs, and histone modifications), shaping gene expression and driving disease pathogenesis.
Ruitong Zeng +6 more
wiley +1 more source
Role of Histone Deacetylase and Inhibitors in Cardiovascular Diseases
Cell Proliferation, Volume 58, Issue 12, December 2025.HDACs play an important role in the occurrence and development of cardiovascular diseases, such as myocardial hypertrophy, hypertension, and atherosclerosis. HDAC inhibitors have broad prospects for the treatment of CVD, and different HDAC subtypes can act through different mechanisms.
Li‐Ying Zhang +4 more
wiley +1 more source
Unconventional structure and function of PHD domains from additional sex combs‐like proteins
The FEBS Journal, Volume 292, Issue 24, Page 6626-6643, December 2025.A plant homeodomain (PHD) at the C terminus of additional sex combs‐like (ASXL) proteins is recurrently truncated in disease. In the current study, the ASXL PHD was shown not to bind histone modifications. Instead, a complex between the ASXL PHD and methyl CpG‐binding domain proteins 5 and 6 (MBD5/6) was investigated.
Cameron J. Reddington +4 more
wiley +1 more source
, 2005 Innate and adaptive immunity are connected via antigen processing and presentation (APP), which results in the presentation of antigenic peptides to T cells in the complex with the major histocompatibility (MHC) determinants.
Drozina, G. +3 more
core +2 more sources
Binding to nucleosome poises human SIRT6 for histone H3 deacetylation
eLifeSirtuin 6 (SIRT6) is an NAD+-dependent histone H3 deacetylase that is prominently found associated with chromatin, attenuates transcriptionally active promoters and regulates DNA repair, metabolic homeostasis and lifespan.
Ekaterina Smirnova +4 more
doaj +1 more source
Calculation of complex DNA damage induced by ions
, 2011 This paper is devoted to the analysis of the complex damage of DNA irradiated by ions. The analysis and assessment of complex damage is important because cells in which it occurs are less likely to survive because the DNA repair mechanisms may not be ...
Gallagher, David C. +2 more
core +1 more source
Journal of Biological Chemistry, 2001 The rate of transcription through the nucleosome, the fine structure of the nucleosomal barrier, and the fate of the nucleosome during transcription at different salt concentrations were analyzed using linear 227-base pair mononucleosomal templates ...
W. Walter, V. Studitsky
semanticscholar +1 more source
Competitive titration in living sea urchin embryos of regulatory factors required for expression of the CyIIIa actin gene [PDF]
, 1990 Previous studies have located some twenty distinct sites within the 2.3 kb 5' regulatory domain of the sea urchin CyIIIa cytoskeletal actin gene, where there occur in vitro high-specificity interactions with nuclear DNA-binding proteins of the embryo ...
Anderson, Roger +5 more
core
Statistical mechanics of nucleosome ordering by chromatin structure-induced two-body interactions
, 2011 One-dimensional arrays of nucleosomes (DNA-bound histone octamers separated by stretches of linker DNA) fold into higher-order chromatin structures which ultimately make up eukaryotic chromosomes.
Chereji, Răzvan V. +3 more
core +1 more source