Results 51 to 60 of about 186,634 (241)

The exocyclic groups of DNA modulate the affinity and positioning of the histone octamer

Proceedings of the National Academy of Sciences of the United States of America, 1998
Memmo Buttinelli, Andrew Minnock, Gianna Panetta, Michael J. Waring, Andrew Travers   +4 more
openalex   +3 more sources

The chromatin remodeller ACF acts as a dimeric motor to space nucleosomes. [PDF]

, 2009
Evenly spaced nucleosomes directly correlate with condensed chromatin and gene silencing. The ATP-dependent chromatin assembly factor (ACF) forms such structures in vitro and is required for silencing in vivo.
Acevedo, Ashley, Cheng, Yifan, Cooke, Roger, Naber, Nariman, Narlikar, Geeta J, Partensky, Peretz D, Purcell, Thomas J, Racki, Lisa R, Yang, Janet G   +8 more
core   +2 more sources

A NMR study of mobility in the histone octamer [PDF]

FEBS Letters, 1990
The histone octamer from chicken erythrocytes was studied in 2 M NaCI using 500 mHz 1H NMR spectroscopy. We compared the spectrum of control octamers with that of octamers isolated from trypsinized nucleosome core particles. We observe that the sharp resonances found in the spectrum of the native octamer disappear completely after trypsinization ...
Schroth, Gary P., Yau, Peter, Imai, Brian S., Gatewood, Joe M., Bradbury, E.Morton   +4 more
openaire   +2 more sources

Cryo-EM structures of remodeler-nucleosome intermediates suggest allosteric control through the nucleosome

eLife, 2019
The SNF2h remodeler slides nucleosomes most efficiently as a dimer, yet how the two protomers avoid a tug-of-war is unclear. Furthermore, SNF2h couples histone octamer deformation to nucleosome sliding, but the underlying structural basis remains unknown.
Jean Paul Armache, Nathan Gamarra, Stephanie L Johnson, John D Leonard, Shenping Wu, Geeta J Narlikar, Yifan Cheng   +6 more
doaj   +1 more source

Partial Unwrapping and Histone Tail Dynamics in Nucleosome Revealed by Coarse-Grained Molecular Simulations. [PDF]

PLoS Computational Biology, 2015
Nucleosomes, basic units of chromatin, are known to show spontaneous DNA unwrapping dynamics that are crucial for transcriptional activation, but its structural details are yet to be elucidated.
Hiroo Kenzaki, Shoji Takada
doaj   +1 more source

Chronopotentiometric Analysis of Single Histones and Histone Octamer at Charged Surfaces

ChemElectroChem, 2021
AbstractHistones play an essential role in the nucleosome structure and organization. The key role of highly positively charged histones is to stabilize negatively charged DNA inside the chromatin. Histones are basic proteins containing a large amount of electroactive residues, namely, arginine and lysine.
Eva Melníková, Tatiana Galicová, Miroslav Gál, Veronika Ostatná   +3 more
openaire   +1 more source

Statistical-mechanical lattice models for protein-DNA binding in chromatin [PDF]

, 2010
Statistical-mechanical lattice models for protein-DNA binding are well established as a method to describe complex ligand binding equilibriums measured in vitro with purified DNA and protein components. Recently, a new field of applications has opened up
Adams C C, Akhrem A A, Bash R C, Gurskii G V, Gurskii G V, Hill T L, Iovanovich B, Karsten Rippe, Lando D Y, Lando D Y, Längst G, Markov A A, Mirny L A, Nechipurenko Y D, Nechipurenko Y D, Nechipurenko Y D, Poland D, Schellman J A, Svaren J, Teif V B, Teif V B, Teif V B, van Holde K E, Vladimir B Teif, Zasedatelev A S   +24 more
core   +2 more sources

The DNA intercalators ethidium bromide and propidium iodide also bind to core histones

FEBS Open Bio, 2014
Eukaryotic DNA is compacted in the form of chromatin, in a complex with histones and other non-histone proteins. The intimate association of DNA and histones in chromatin raises the possibility that DNA-interactive small molecules may bind to chromatin ...
Amrita Banerjee, Parijat Majumder, Sulagna Sanyal, Jasdeep Singh, Kuladip Jana, Chandrima Das, Dipak Dasgupta   +6 more
doaj   +1 more source

Toward a molecular understanding of yeast silent chromatin : roles for H4K16 acetylation and the Sir3 C-terminus [PDF]

, 2012
Discrete regions of the eukaryotic genome assume a heritable chromatin structure that is refractory to gene expression. In budding yeast, silent chromatin is characterized by the loading of the Silent Information Regulatory (Sir) proteins (Sir2, Sir3 and
Oppikofer, Mariano
core   +1 more source

Phylogenetic analysis of the core histone doublet and DNA topo II genes of Marseilleviridae: evidence of proto-eukaryotic provenance

Epigenetics & Chromatin, 2017
Background While the genomes of eukaryotes and Archaea both encode the histone-fold domain, only eukaryotes encode the core histone paralogs H2A, H2B, H3, and H4.
Albert J. Erives
doaj   +1 more source