Results 71 to 80 of about 186,634 (241)
Theory of Nucleosome Corkscrew Sliding in the Presence of Synthetic DNA Ligands
, 2004 Histone octamers show a heat-induced mobility along DNA. Recent theoretical studies have established two mechanisms that are qualitatively and quantitatively compatible with in vitro experiments on nucleosome sliding: Octamer repositiong through one ...
Kulic, Igor M. +2 more
core +2 more sources
Histone H3 localizes to the centromeric DNA in budding yeast. [PDF]
PLoS Genetics, 2012 During cell division, segregation of sister chromatids to daughter cells is achieved by the poleward pulling force of microtubules, which attach to the chromatids by means of a multiprotein complex, the kinetochore.
Berit Lochmann, Dmitri Ivanov
doaj +1 more source
Liquid biopsy epigenetics: establishing a molecular profile based on cell‐free DNA
Molecular Oncology, EarlyView.Cell‐free DNA (cfDNA) fragments in plasma from cancer patients carry epigenetic signatures reflecting their cells of origin. These epigenetic features include DNA methylation, nucleosome modifications, and variations in fragmentation. This review describes the biological properties of each feature and explores optimal strategies for harnessing cfDNA ...
Christoffer Trier Maansson +2 more
wiley +1 more source
Nucleosome mobilization by ISW2 requires the concerted action of the ATPase and SLIDE domains [PDF]
, 2013 The ISWI family of ATP-dependent chromatin remodelers represses transcription by changing nucleosome positioning. The interactions with extranucleosomal DNA and the requirement of a minimal length of extranucleosomal DNA by ISWI mediate the spacing of ...
A Eberharter +38 more
core +2 more sources
A computational model for histone mark propagation reproduces the distribution of heterochromatin in different human cell types. [PDF]
PLoS ONE, 2013 Chromatin is a highly compact and dynamic nuclear structure that consists of DNA and associated proteins. The main organizational unit is the nucleosome, which consists of a histone octamer with DNA wrapped around it.
Veit Schwämmle, Ole Nørregaard Jensen
doaj +1 more source
Cytoplasmic p21 promotes stemness of colon cancer cells via activation of the NFκB pathway
Molecular Oncology, EarlyView.Cytoplasmic p21 promotes colorectal cancer stem cell (CSC) features by destabilizing the NFκB–IκB complex, activating NFκB signaling, and upregulating BCL‐xL and COX2. In contrast to nuclear p21, cytoplasmic p21 enhances spheroid formation and stemness transcription factor CD133.
Arnatchai Maiuthed +10 more
wiley +1 more source
Determining the Influence of Histone Tails on Compaction and Transcription Factor Binding [PDF]
, 2013 Histone octamer tails play an important role in regulating transcription factor binding and nucleosome compaction. In order to determine the mechanisms by which the histone octamer tails play a role in such processes, the tails were labeled with a spin ...
Bravo, Jaime
core
Charged rosettes at high and low ionic strengths
, 2002 The complexation between a semiflexible polyelectrolyte and an oppositely charged macroion leads to a multitude of structures ranging from tight complexes with the chain wrapped around the macroion to open multileafed rosette-like complexes.
Schiessel, Helmut
core +2 more sources
Evolution of histone 2A for chromatin compaction in eukaryotes. [PDF]
, 2014 During eukaryotic evolution, genome size has increased disproportionately to nuclear volume, necessitating greater degrees of chromatin compaction in higher eukaryotes, which have evolved several mechanisms for genome compaction.
Campos, Oscar A +7 more
core +2 more sources
PLoS ONE, 2022 We have performed a comprehensive analysis of the involvement of histone H3 and H4 residues in the regulation of chronological lifespan in yeast and identify four structural groups in the nucleosome that influence lifespan.
Mzwanele Ngubo +2 more
doaj +1 more source