Results 101 to 110 of about 1,411,447 (295)
Modeling hepatic fibrosis in TP53 knockout iPSC‐derived human liver organoids
Molecular Oncology, EarlyView.This study developed iPSC‐derived human liver organoids with TP53 gene knockout to model human liver fibrosis. These organoids showed elevated myofibroblast activation, early disease markers, and advanced fibrotic hallmarks. The use of profibrotic differentiation medium further amplified the fibrotic signature seen in the organoids.
Mustafa Karabicici +8 more
wiley +1 more source
Histone H2A variants play a key role at DNA double-strand breaks during repair pathway choice
Frontiers in Epigenetics and EpigenomicsHistone post-translational modifications and variants play crucial roles in the adaptability of chromatin structure, facilitating rapid responses necessary for biological processes such as transcription, replication, and DNA damage signaling.
Emile Clerf +3 more
doaj +1 more source
Acta Societatis Botanicorum Poloniae, 2011 As continuation of investigations in to the mechanism of the role of the H1 histone, which is a crucial protein component chromosomes of all eukaryotes, transgenic tobacco plants with different levels of the H1 histone variants were examined. Tobacco has
Joanna Ślusarczyk +5 more
doaj +1 more source
Localization of Epigenetic Markers in Leishmania Chromatin
Pathogens, 2022 Eukaryotes use histone variants and post-translation modifications (PTMs), as well as DNA base modifications, to regulate DNA replication/repair, chromosome condensation, and gene expression. Despite the unusual organization of their protein-coding genes
Jacquelyn R. McDonald +5 more
doaj +1 more source
MacroH2A histone variants limit chromatin plasticity through two distinct mechanisms
EMBO Reports, 2018 MacroH2A histone variants suppress tumor progression and act as epigenetic barriers to induced pluripotency. How they impart their influence on chromatin plasticity is not well understood.
M. Kozłowski +15 more
semanticscholar +1 more source
A synthetic benzoxazine dimer derivative targets c‐Myc to inhibit colorectal cancer progression
Molecular Oncology, EarlyView.Benzoxazine dimer derivatives bind to the bHLH‐LZ region of c‐Myc, disrupting c‐Myc/MAX complexes, which are evaluated from SAR analysis. This increases ubiquitination and reduces cellular c‐Myc. Impairing DNA repair mechanisms is shown through proteomic analysis.
Nicharat Sriratanasak +8 more
wiley +1 more source
A catalog of potential putative functional variants in psoriasis genome-wide association regions. [PDF]
PLoS ONE, 2018 Psoriasis is a common inflammatory skin disease, with considerable genetic contribution. Genome-wide association studies have successfully identified a number of genomic regions for the risk of psoriasis.
Yan Lin +8 more
doaj +1 more source
The Drosophila histone variant H2A.V works in concert with HP1 to promote kinetochore-driven microtubule formation [PDF]
, 2015 Unlike other organisms that have evolved distinct H2A variants for different functions, Drosophila melanogaster has just one variant which is capable of filling many roles.
Cenci, Giovanni, Verni', Fiammetta
core +1 more source
Molecular Oncology, EarlyView.Detection of extrachromosomal circular DNA (eccDNA) in plasma samples from EGFR‐mutated non‐small cell lung cancer patients. Plasma was collected before and during treatment with the EGFR‐tyrosine kinase inhibitor osimertinib. Plasma eccDNA was detected in all cancer samples, and the presence of the EGFR gene on eccDNA serves as a potential biomarker ...
Simone Stensgaard +5 more
wiley +1 more source
SWI/SNF-like chromatin remodeling factor Fun30 supports point centromere function in S. cerevisiae [PDF]
, 2011 Budding yeast centromeres are sequence-defined point centromeres and are, unlike in many other organisms, not embedded in heterochromatin. Here we show that Fun30, a poorly understood SWI/SNF-like chromatin remodeling factor conserved in humans ...
Anna T. Vetter +13 more
core +9 more sources