Results 31 to 40 of about 1,411,447 (295)
Using genomic annotations increases statistical power to detect eGenes. [PDF]
, 2016 MotivationExpression quantitative trait loci (eQTLs) are genetic variants that affect gene expression. In eQTL studies, one important task is to find eGenes or genes whose expressions are associated with at least one eQTL. The standard statistical method
Duong, Dat +6 more
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Histone variants: deviants? [PDF]
Genes & Development, 2005 Histones are a major component of chromatin, the protein-DNA complex fundamental to genome packaging, function, and regulation. A fraction of histones are nonallelic variants that have specific expression, localization, and species-distribution patterns.
Rohinton T, Kamakaka, Sue, Biggins
openaire +2 more sources
Quantitative Kinetic Analyses of Histone Turnover Using Imaging and Flow Cytometry
Bio-Protocol, 2020 Dynamic histone changes occur as a central part of chromatin regulation. Deposition of histone variants and post-translational modifications of histones are strongly associated with properties of chromatin status.
Hanae Sato, Robert Singer, John Greally
doaj +1 more source
Chromosome Centromeres: Structural and Analytical Investigations with High Resolution Scanning Electron Microscopy in Combination with Focused Ion Beam Milling [PDF]
, 2009 Whole mount mitotic metaphase chromosomes of different plants and animals were investigated with high resolution field emission scanning electron microscopy (FESEM) to study the ultrastructural organization of centromeres, including metacentric ...
Schroeder-Reiter, E., Wanner, Gerhard
core +1 more source
A Read/Write Mechanism Connects p300 Bromodomain Function to H2A.Z Acetylation
iScience, 2019 Summary: Acetylation of the histone variant H2A.Z (H2A.Zac) occurs at active regulatory regions associated with gene expression. Although the Tip60 complex is proposed to acetylate H2A.Z, functional studies suggest additional enzymes are involved.
Yolanda Colino-Sanguino +10 more
doaj +1 more source
Frontiers in Immunology, 2022 In teleost fish, the nucleotide polymorphisms of histone H2A significantly affect the resistance or susceptibility of zebrafish to Edwardsiella piscicida infection.
Yuan Yuan Yang +10 more
doaj +1 more source
ATP-dependent chromatosome remodeling [PDF]
, 2008 Chromatin serves to package, protect and organize the complex eukaryotic genomes to assure their stable inheritance over many cell generations. At the same time, chromatin must be dynamic to allow continued use of DNA during a cell's lifetime.
Dimitrov S. +6 more
core +1 more source
Mutations in the PKM2 exon-10 region are associated with reduced allostery and increased nuclear translocation. [PDF]
, 2019 PKM2 is a key metabolic enzyme central to glucose metabolism and energy expenditure. Multiple stimuli regulate PKM2's activity through allosteric modulation and post-translational modifications.
Chen, Tsan-Jan +11 more
core +3 more sources
Mice without MacroH2A Histone Variants [PDF]
Molecular and Cellular Biology, 2014 MacroH2A core histone variants have a unique structure that includes a C-terminal nonhistone domain. They are highly conserved in vertebrates and are thought to regulate gene expression. However, the nature of genes regulated by macroH2As and their biological significance remain unclear.
John R, Pehrson +3 more
openaire +2 more sources
Reciprocal intronic and exonic histone modification regions in humans. [PDF]
, 2010 While much attention has been focused on chromatin at promoters and exons, human genes are mostly composed of intronic sequences. Analyzing published surveys of nucleosomes and 41 chromatin marks in humans, we identified histone modifications ...
Guthrie, Christine +3 more
core +2 more sources