Results 91 to 100 of about 317,398 (334)
A nucleotide‐independent, pan‐RAS‐targeted DARPin elicits anti‐tumor activity in a multimodal manner
Molecular Oncology, EarlyView.We report a Designed Ankyrin Repeat Protein that binds and inhibits RAS proteins, which serve as central cell signaling hubs and are essential for the progression of many cancers. Its unique feature is that it does not discriminate between different RAS isoforms or mutations and is capable of binding to RAS in both its active (GTP‐bound) and inactive ...
Jonas N. Kapp +13 more
wiley +1 more source
Balkan Medical Journal, 2020 Background:Myocardial impairment is a major complication and an important prognostic predictor of sepsis. Therefore, early and accurate diagnosis as well as timely management of septic cardiomyopathy is critical to achieve favorable outcomes.Aims:To ...
Nian-Fang Lu +7 more
doaj +1 more source
Site-specific opening of the blood-brain barrier by extracellular histones
Journal of Neuroinflammation, 2020 Background Increased extracellular histones in the bloodstream are known as a biomarker for vascular dysfunction associated with severe trauma or sepsis.
Nuria Villalba +3 more
doaj +1 more source
Epigenetic marking of sperm by post-translational modification of histones and protamines
Epigenetics & Chromatin, 2014 BackgroundThe concept that individual traits can be acquired and transmitted by the germline through epigenetic mechanisms has gained recognition in the past years.
A. M. Brunner, P. Nanni, I. Mansuy
semanticscholar +1 more source
Molecular Oncology, EarlyView.Overexpression of CHRDL2 in colon cancer cells makes them more stem‐like and resistant to chemo‐ and radiotherapy. CHRDL2‐high cells have upregulation of the WNT pathway, genes involved in the DNA damage response (DDR) pathway and epithelial‐to‐mesenchymal transition (EMT). This leads to quicker repair of damaged DNA and more cell migration.
Eloise Clarkson, Annabelle Lewis
wiley +1 more source
Histones: At the Crossroads of Peptide and Protein Chemistry
Chemical Reviews, 2014 In eukaryotic cells, inheritable information is stored in a nucleoprotein complex referred to as chromatin.1 This genome architecture serves two key purposes.
Manuel M Müller, T. Muir
semanticscholar +1 more source
Molecular Oncology, EarlyView.TRIM24 and TRIM28 are androgen receptor (AR) coregulators which exhibit increased expression with cancer progression. Both TRIM24 and TRIM28 combine to influence the response of castrate‐resistant prostate cancer (CRPC) cells to AR inhibitors by mediating AR signalling, regulation of MYC and upregulating VEGF to promote angiogenesis. Castrate‐resistant
Damien A. Leach +8 more
wiley +1 more source
COMPARATIVE STRUCTURAL STABILITY OF HISTONES BY INTERACTION OF SODIUM NDODECYL SULPHATE [PDF]
Journal of Sciences, Islamic Republic of Iran, 1991 The interaction of sodium n-dodecyl sulphate (SDS) with histones in phosphate buffer pH 6.4 has been studied spectroscopically and by equilibrium dialysis.
doaj
Lysine Succinylation and Lysine Malonylation in Histones*
Molecular & Cellular Proteomics, 2012 Histone protein post-translational modifications (PTMs) are significant for gene expression and DNA repair. Here we report the identification and validation of a new type of PTM in histones, lysine succinylation.
Zhongyu Xie +7 more
semanticscholar +1 more source
Molecular Oncology, EarlyView.Analysis of treatment‐naïve high‐grade serous ovarian carcinoma (HGSOC) and control tissues for ERVs, LINE‐1 (L1), inflammation, and immune checkpoints identified five clusters with diverse patient recurrence‐free survivals. An inflammation score was calculated and correlated with retroelement expression, where one novel cluster (Triple‐I) with high ...
Laura Glossner +6 more
wiley +1 more source