Results 91 to 100 of about 61,334 (223)
Suboptimal extracellular pH values alter DNA damage response to induced double‐strand breaks
FEBS Open Bio, 2018 Conditions leading to unrepaired DNA double‐stranded breaks are potent inducers of genetic instability. Systemic conditions may lead to fluctuation of hydrogen ions in the cellular microenvironment, and we show that small variations in extracellular pH ...
Julien Massonneau +5 more
doaj +1 more source
Advanced Biology, EarlyView.Hypoxia promotes the epithelial‐mesenchymal transition (EMT) of renal tubular epithelial cells via the SIRT1‐FoxO1‐FoxO3‐autophagy pathway, thereby resulting in the fibrosis of renal tubular epithelial cells. Activation of SIRT1 or induction of autophagy inhibits this process, alleviating hypoxia‐induced fibrosis.
Guangyu Wang +6 more
wiley +1 more source
Ageing-Related Changes to H3K4me3, H3K27ac, and H3K27me3 in Purified Mouse Neurons
CellsNeurons are central to lifelong learning and memory, but ageing disrupts their morphology and function, leading to cognitive decline. Although epigenetic mechanisms are known to play crucial roles in learning and memory, neuron-specific genome-wide ...
Brandon Signal +7 more
doaj +1 more source
Histones of Mitosis and Meiosis in Loxa flavicolis (Hemipteran) [PDF]
, 1958 Hudson R. Ansley
openalex +1 more source
Advanced Biology, EarlyView.Extracellular vesicles (EVs) play a dual role in diagnostics and therapeutics, offering innovative solutions for treating cancer, cardiovascular, neurodegenerative, and orthopedic diseases. This review highlights EVs’ potential to revolutionize personalized medicine through specific applications in disease detection and treatment.
Farbod Ebrahimi +4 more
wiley +1 more source
The entropic lock and key of the histone code [PDF]
arXiv, 2013 The intricate pattern of chemical modifications on DNA and histones, the "histone code", is considered to be a key gene regulation factor. Multivalency is seen by many as an essential instrument to transmit the "encoded" information to the transcription machinery via multi-domain effector proteins and chromatin-associated complexes.
arxiv
Advanced Functional Materials, EarlyView.On‐cell covalent crosslinking of hydrogel matrix to the membrane of a single cell using droplet microfluidics enables mechanotransduction and influences stem cell fate. This newly established approach influences stem cell fate, independent of YAP/TAZ mechanotransduction and non‐covalent reversible binding ligands yet by various intracellular ...
Castro Johnbosco +6 more
wiley +1 more source
Destabilization of the outer and inner mitochondrial membranes by core and linker histones.
PLoS ONE, 2012 BackgroundExtensive DNA damage leads to apoptosis. Histones play a central role in DNA damage sensing and may mediate signals of genotoxic damage to cytosolic effectors including mitochondria.Methodology/principal findingsWe have investigated the effects
Annunziata Cascone +4 more
doaj +1 more source