Results 111 to 120 of about 61,334 (223)
Analysis of interaction partners of H4 histone by a new proteomics approach [PDF]
arXiv, 2009 We describe a modification of the TAP method for purification and analysis of multiprotein complexes, termed here DEF-TAP (for Differential Elution Fractionation after Tandem Affinity Purification). Its essential new feature is the use for last purification step of 6XHis-Ni++ interaction, which is resistant to a variety of harsh washing conditions ...
arxiv
Roles of Kdm6a and Kdm6b in Regulation of Mammalian Neural Regeneration
Advanced Science, EarlyView.This study reveals that Kdm6a plays key roles in repressing either peripheral nervous system (PNS) or central nervous system (CNS) axon regeneration, whereas Kdm6b is not involved in regulating CNS axon regeneration. Moreover, both demethylases are able to regulate CNS neuronal survival after injury, but with non‐overlapping mechanisms.
Shu‐Guang Yang +13 more
wiley +1 more source
N-terminal acetyl-peptides from two calf thymus histones [PDF]
, 1968 D. M. P. Phillips
openalex +1 more source
Chromatin Organization Governs Transcriptional Response and Plasticity of Cancer Stem Cells
Advanced Science, EarlyView.Through a combination of transcriptomic and histone mapping studies integrated with chromatin imaging, we define how chromatin organization in nanoscale packing domains fine tunes the plasticity of cancer stem cells (CSCs) driving evasion from and survival after chemotherapy.
Yinu Wang +20 more
wiley +1 more source
Targeting KMT5C Suppresses Lung Cancer Progression and Enhances the Efficacy of Immunotherapy
Advanced Science, EarlyView.This study reveals that KMT5C activates DNA damage repair to inhibit STING‐IRF3 pathway, downstream type I IFN signaling and CCL5 secretion, leading to the downregulation of CD8+ T cell infiltration and function in NSCLC, ultimately facilitating tumor progression.
Yunfeng Yuan +11 more
wiley +1 more source
DILUTION OF POLIOVIRUS RIBONUCLEIC ACID AS AN IMPORTANT STEP IN OBTAINING INFECTIVITY WITH HISTONE [PDF]
, 1964 E. H. Ludwig, Christine E. Smull
openalex +1 more source
Shrimp Virus Regulates ROS Dynamics via the Nrf2 Pathway to Facilitate Viral Replication
Advanced Science, EarlyView.Viruses manipulate host ROS as a strategy to achieve successful infection. WSSV exploits Nrf2 pathway to maintain ROS homeostasis and establishes a positive feedback loop to facilitate WSSV replication. Wsv220 competitively binds to Keap1 to activate Nrf2. Nrf2 up‐regulates LvG6PDH to produce more NADPH and GSH to eliminate excessive ROS.
Honghui He +6 more
wiley +1 more source
Fractionation of the lysine-rich histones [PDF]
, 1969 Richard H. Buckingham, L. A. Stocken
openalex +1 more source
Advanced Science, EarlyView.D‐galactose (D‐gal) induced inner ear hair cell senescence by inhibiting TFEB transcription. RONIN/HCF1 promotes TFEB transcription to prevent cochlear HCs from D‐gal‐induced senescence through autophagy activation. Abstract Age‐related hearing loss is characterized by senescent inner ear hair cells (HCs) and reduced autophagy.
Yongjie Wei +18 more
wiley +1 more source