Results 41 to 50 of about 317,398 (334)
Histone Citrullination Mediates a Protective Role in Endothelium and Modulates Inflammation
Cells, 2022 NETosis is a key host immune process against a pathogenic infection during innate immune activation, consisting of a neutrophil “explosion” and, consequently, NET formation, containing mainly DNA, histones, and other nuclear proteins.
Rebeca Osca-Verdegal +8 more
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Histones as mediators of host defense, inflammation and thrombosis.
Future Microbiology, 2016 Histones are known for their ability to bind to and regulate expression of DNA. However, histones are also present in cytoplasm and extracellular fluids where they serve host defense functions and promote inflammatory responses.
M. Hoeksema +3 more
semanticscholar +1 more source
Frontiers in Plant Science, 2020 Chromatin regulation ensures stable repression of stress-inducible genes under non-stress conditions and transcriptional activation and memory of stress-related genes after stress exposure.
Kora Vyse +6 more
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Diseases, 2021 Lysine methylation is among the key posttranslational modifications to histones that contribute to epigenetic regulation. SMYD3 is a lysine methyltransferase that is essential for the proliferation of a range of tumorigenic cells. The findings that SMYD3
Dillon K. Jarrell +4 more
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Histone Deacetylases and Histone Deacetylase Inhibitors in Neuroblastoma [PDF]
Frontiers in Cell and Developmental Biology, 2020 Histone deacetylases (HDACs) are enzymes that play a key role in regulating gene expression by remodeling chromatin structure. An imbalance of histone acetylation caused by deregulated HDAC expression and activity is known to promote tumor progression in a number of tumor types, including neuroblastoma, the most common solid tumor in children ...
Monica Phimmachanh +6 more
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Journal of Emergencies, Trauma and Shock, 2013 Background: Tissue injury increases blood levels of extracellular histones and nucleic acids, and these may influence hemostasis, promote inflammation and damage the endothelium. Trauma-induced coagulopathy (TIC) may result from an endogenous response to
Pär I Johansson +4 more
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H2A-H2B Histone Dimer Plasticity and Its Functional Implications
Cells, 2022 The protein core of the nucleosome is composed of an H3-H4 histone tetramer and two H2A-H2B histone dimers. The tetramer organizes the central 60 DNA bp, while H2A-H2B dimers lock the flanking DNA segments. Being positioned at the sides of the nucleosome,
Anastasiia S. Kniazeva +2 more
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Role of histone tyrosines in nucleosome formation and histone-histone interaction.
Journal of Biological Chemistry, 1984 We have studied the functional properties of iodinated histones. Isolated, denatured histones were iodinated at trace levels and then renatured together with carrier histones and high molecular weight DNA to form nucleohistone. Nucleosomes were prepared from the reconstitute using micrococcal nuclease, and the relative representations of the individual
H G Martinson, A M Kleinschmidt
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FoxO1 signaling in B cell malignancies and its therapeutic targeting
FEBS Letters, EarlyView.FoxO1 has context‐specific tumor suppressor or oncogenic character in myeloid and B cell malignancies. This includes tumor‐promoting properties such as stemness maintenance and DNA damage tolerance in acute leukemias, or regulation of cell proliferation and survival, or migration in mature B cell malignancies.
Krystof Hlavac +3 more
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Current Approaches to Epigenetic Therapy
Epigenomes, 2023 Epigenetic therapy is a promising tool for the treatment of a wide range of diseases. Several fundamental epigenetic approaches have been proposed. Firstly, the use of small molecules as epigenetic effectors, as the most developed pharmacological method,
Ekaterina D. Griazeva +10 more
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