Results 41 to 50 of about 239,429 (335)

Probing the (H3-H4)(2) histone tetramer structure using pulsed EPR spectroscopy combined with site-directed spin labelling [PDF]

open access: yes, 2009
The (H3-H4)2 histone tetramer forms the central core of nucleosomes and, as such, plays a prominent role in assembly, disassembly and positioning of nucleosomes.
Bowman, A.   +4 more
core   +5 more sources

Activation of AMP-activated protein kinase by metformin induces protein acetylation in prostate and ovarian cancer cells [PDF]

open access: yes, 2016
AMP-activated protein kinase (AMPK) is an energy sensor and master regulator of metabolism. AMPK functions as a fuel gauge monitoring systemic and cellular energy status.
Galdieri, Luciano   +3 more
core   +2 more sources

Proteomic Analysis of Serum Lysine Acetylation in Uyghur Patients With T2DM

open access: yesFrontiers in Molecular Biosciences, 2022
Lysine acetylation is a reversible modification process after protein translation, which plays a key regulatory role in various metabolic diseases such as diabetes.
Liang Yin   +3 more
doaj   +1 more source

Redistribution of Histone Marks on Inflammatory Genes Associated With Intracerebral Hemorrhage-Induced Acute Brain Injury in Aging Rats

open access: yesFrontiers in Neuroscience, 2022
The contribution of histone mark redistribution to the age-induced decline of endogenous neuroprotection remains unclear. In this study, we used an intracerebral hemorrhage (ICH)-induced acute brain injury rat model to study the transcriptional and ...
Qin Zhang   +14 more
doaj   +1 more source

Histone acetyltransferase 1 is a succinyltransferase for histones and non‐histones and promotes tumorigenesis

open access: yesEMBO reports, 2020
Lysine succinylation (Ksucc) is an evolutionarily conserved and widespread post-translational modification. Histone acetyltransferase 1 (HAT1) is a type B histone acetyltransferase, regulating the acetylation of both histone and non-histone proteins. However, the role of HAT1 in succinylation modulation remains unclear.
Guang Yang   +14 more
openaire   +3 more sources

AIP1 is a novel Agenet/Tudor domain protein from Arabidopsis that interacts with regulators of DNA replication, transcription and chromatin remodeling [PDF]

open access: yes, 2015
Background: DNA replication and transcription are dynamic processes regulating plant development that are dependent on the chromatin accessibility. Proteins belonging to the Agenet/Tudor domain family are known as histone modification "readers" and ...
Barroso-Neto, Ito Liberato   +9 more
core   +3 more sources

Distinctive Nuclear Features of Dinoflagellates with A Particular Focus on Histone and Histone-Replacement Proteins

open access: yesMicroorganisms, 2018
Dinoflagellates are important eukaryotic microorganisms that play critical roles as producers and grazers, and cause harmful algal blooms. The unusual nuclei of dinoflagellates “dinokaryon„ have led researchers to investigate their enigmatic ...
Sadaf Riaz   +5 more
doaj   +1 more source

Elevated Plasma Histone H4 Levels Are an Important Risk Factor in the Development of Septic Cardiomyopathy

open access: yesBalkan Medical Journal, 2020
Background:Myocardial impairment is a major complication and an important prognostic predictor of sepsis. Therefore, early and accurate diagnosis as well as timely management of septic cardiomyopathy is critical to achieve favorable outcomes.Aims:To ...
Nian-Fang Lu   +7 more
doaj   +1 more source

Extracting histones for the specific purpose of label-free MS [PDF]

open access: yes, 2016
Extracting histones from cells is the first step in studies that aim to characterize histones and their post-translational modifications (hPTMs) with MS.
De Clerck, Laura   +9 more
core   +2 more sources

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