Results 111 to 120 of about 8,202,239 (241)

Review of Gastrointestinal Capsule Robots: Materials, Actuation, Diagnostics, and Therapeutics

Advanced Science, EarlyView.
This review examines gastrointestinal capsule robots through a systems engineering lens, covering shell materials, actuation and localization strategies, diagnostic modalities, therapeutic interventions, and commercialization status. By mapping the complete technological chain from fabrication to clinical deployment, this work identifies critical gaps ...
Zengsheng Li, Zhongguo Ren, Yiliang Lin, Xianfeng Xia, Tianlong Li, Kai Fung Chan, Philip Wai Yan Chiu, Wei Peng Yong, Mengmeng Sun   +8 more
wiley   +1 more source

Deciphering Anti‐Cancer Drug Efficacy Through Nanomechanical Vibrations in Living Gastric Cancer Organoids

Advanced Science, EarlyView.
This study developed an efficacy assessment platform that integrates patient‐derived gastric cancer organoids, atomic force microscopy (AFM)‐based nanomechanical vibration detection, deep learning analysis, and organoid mechanical modeling. It detects picomolar drug effects within 0.1 s signal, achieves 97% classification accuracy, and offers non ...
Ting Zhang, Qiubo Chen, Shihai Lan, Liang Zhu, Shuaiyu Liu, Yan Xia, Yalu Zhang, Hanhui Yao, Yongman Liu, Shangquan Wu, Qingchuan Zhang   +10 more
wiley   +1 more source

Morphological patterns of pneumonia in free-roaming cats: a necropsy and histopathological study

Frontiers in Veterinary Science
BackgroundPneumonia is a significant cause of morbidity and mortality in free-roaming domestic cats, particularly when associated with infectious agents and underlying systemic conditions. Post-mortem studies remain essential for characterizing pulmonary
Rubia Avlade Guedes Sampaio, Gedean Galdino da Cruz Silva, Gabriela Santina Costa Henrique, Vinícius Mendes Gonçalves, Victória Maria Belarmino dos Santos, Wanessa Otoni de Souza Silva, Danielly Santos Silva, Markyson Tavares Linhares, Lucas Rannier Ribeiro Antonino Carvalho, Ricardo Barbosa Lucena   +9 more
doaj   +1 more source

Circulating tumour cells are associated with histopathological growth patterns of colorectal cancer liver metastases. [PDF]

Clin Exp Metastasis, 2023
Meyer YM, Wilting SM, Kraan J, Olthof P, Vermeulen P, Martens J, Grünhagen DJ, Sleijfer S, Verhoef C.   +8 more
europepmc   +1 more source

A Rare De Novo Missense Mutation in IFT122 Confers a Genetic Susceptibility Factor of Idiopathic Pediatric Uveitis Via Trio‐based Whole‐Exome Sequencing

Advanced Science, EarlyView.
A rare de novo IFT122‐A773E variant is identified in idiopathic pediatric uveitis and shown to exacerbate retinal inflammation and barrier dysfunction. Mechanistically, the variant enhances IFT43 interaction, elevates calcium signaling, and activates the MEK/ERK/FRA1 axis, revealing a previously unrecognized cilia‐associated pathway that may increase ...
Qian Zhou, Jiaxing Huang, Yilin Wang, Xingran Li, Xianyang Liu, Lingyu Dai, Hongshun Li, Qingfeng Wang, Jiangyi Liu, Guannan Su, Wanyun Zhang, Yang Deng, Qingfeng Cao, Yujie Lai, Xiang Luo, Changwei Huang, Ling Chen, Shengping Hou, Peizeng Yang   +18 more
wiley   +1 more source

Intracholecystic Papillary Neoplasm With Associated Invasive Carcinoma, Accompanied by Tumor Thrombi of Hepatoid Adenocarcinoma: A Case Report

Case Reports in Pathology
Hepatoid adenocarcinoma (HAC) is a rare extrahepatic adenocarcinoma characterized by hepatocellular differentiation. HAC arising in the gallbladder is rare. We report a case of intracholecystic papillary neoplasm (ICPN) with HAC, most of which were tumor
Sho Yoshida, Yusuke Kouchi, Ryotaro Eto, Masayuki Ohtsuka, Takashi Kishimoto   +4 more
doaj   +1 more source

Integrated Radiographic and Histopathological Characterization of Morphological Deformities in Farmed Rainbow Trout (Oncorhynchus mykiss)

Fishes
Morphological and skeletal deformities compromise growth, swimming, feeding, welfare, and market value in farmed fish, but externally visible abnormalities may not reveal the underlying tissue lesions.
Rümeysa Şen, Buket Albayrak, Arda Deniz Gür, Onur Onguncan, Nihed Ajmi, Görkem Taşçı, Sabire Güler, Muhammed Duman   +7 more
doaj   +1 more source

Nickel‐Catalyzed Three‐Component Difluoroalkylation‐Amination for the Direct Access to Anti‐Inflammatory β‐Difluoroalkyl Amines

Advanced Science, EarlyView.
A nickel‐catalyzed three‐component reductive fluoroalkylation‐amination strategy of N‐vinylamides for the direct access to the α‐amidyl‐β‐difluoroalkyl amines was reported here. The synthetic method features with broad substrate scope, mild conditions, high functional group tolerance, and convenience to handle.
Chang Xu, Fangting Ma, Fan Ding, Luyan Wang, Yunxi Li, Yunzhi He, Xingang Zhang, Siyu He, Dandan Liu   +8 more
wiley   +1 more source

Blood Cell‐Camouflaged Liquid Metal Nanoconjugates Orchestrate Treg Depletion and STING‐Amplified Photothermal Immunity for Metastatic Triple‐Negative Breast Cancer Therapy

Advanced Science, EarlyView.
Whole‐blood biomimetic engineering transforms liquid metal nanoparticles into a tripartite immunotherapeutic platform that orchestrates regulatory T‐cell depletion, photothermal‐induced immunogenic cell death, and activation of the stimulator of interferon genes pathway.
Nina Sang, Eijiro Miyako
wiley   +1 more source

Dose-dependent effects of extracted microcystins on embryonic development, larval growth and histopathological changes of southern catfish (Silurus meridionalis)

, 2008
A laboratory toxic experiment was conducted to examine dose-dependent effects of extracted microcystins (MCs) on embryonic development, larval growth and histopathological changes of southern catfish (Silurus meridionalis). Fertilized eggs were incubated
Wang, Weimin, Li, Li, Li, Dapeng, Xie, P, Chinese Acad Sci, Inst Hydrobiol, State Key Lab Freshwater Ecol & Biotechnol China, Donghu Expt Stn Lake Ecosyst, Wuhan 430072, Peoples R China, Tang, Rong, Shi, Zechao, Zhang, Xuezhen, Xie, Ping, Lei, Hehua   +8 more
core   +1 more source