Results 121 to 130 of about 8,202,239 (241)

Alternating Shear Force of Respiration Regulates Cell Interactions of Fibroblasts and Macrophages to Promote Soft Tissue Integration of Chest Wall Polyetheretherketone Implants

Advanced Science, EarlyView.
Given that PEEK chest wall implants induce shear force at the soft tissue‐implant interface due to respiratory motion in the early in vivo post‐implantation stage. We confirmed that this mechanical stimulus triggers the PIEZO1/ITGB1/YAP1 signalling axis in L929 and the STAT6/p‐STAT6 pathway in RAW264.7, which in turn mediates adhesion and migration of ...
Rou Huang, Yangfan Huo, Jin Liu, Sida Liu, Minghai Ma, Hao Guo, Yuanquan Zhang, Xing Li, Xiao Liang, Jiawei Xiu, Ying Sun, Lijun Huang, Xiaolong Yan, Weiwei Wu, Lei Wang   +14 more
wiley   +1 more source

Investigation of three alternative histopathological scoring methods at the invasive tumour front in colorectal cancer

The Journal of Pathology: Clinical Research
Although the characteristics at the invasive tumour front in colorectal cancer (CRC) are simple to assess, they are not included in routine pathology reports because they lack reproducibility and standardisation.
Walaiphorn Woraharn, Ashley McCulloch, Christopher Bigley, Phimmada Hatthakarnkul, Kathryn Pennel, Peter Alexander, Hester vanWyk, Antonia Roseweir, Jennifer Hay, Noori Maka, James Park, Nigel B Jamieson, Joanne Edwards, Campbell SD Roxburgh   +13 more
doaj   +1 more source

Diagnostic dilemma in gastroduodenal lesions: Heterotopic pancreas mimicking gastrointestinal stromal tumours managed by minimally invasive approach – A case series and review of the literature

Journal of Minimal Access Surgery
Background: Heterotopic pancreas (HP) is a rare congenital anomaly, characterised by ectopic pancreatic tissue lacking anatomical and vascular continuity with the main pancreas.
D. Raghavendra, S. Gilbert Samuel Jebakumar, Jeevanandham Muthiah, Gaurav Chinappa, Siddhesh Suresh Tasgaonkar, Venkatesh Munikrishnan, Sudeepta Kumar Swain   +6 more
doaj   +1 more source

Dual‐Responsive Hydrogels Integrate Bioelectrical Stimulation and Piezo‐Photocatalysis for Regenerative Treatment of Infected Wounds

Advanced Science, EarlyView.
A wireless, dual‐responsive hydrogel (PVA/(PVDF‐TrFE)/BiOClBr@PDA) is developed to promote efficient regeneration of infected wounds by integrating piezoelectric stimulation with piezo‐photocatalytic pathways. Under simultaneous light and ultrasonic stimulation, the hydrogel generates therapeutic electrical cues and reactive oxygen species, disrupting ...
Baoying Dai, Wenxuan Qie, Xiaoye Li, Jingben Zheng, Ao He, Heng Dong, Jiangjiang Yan, Hao Zhang, Ziheng Pan, Hang Yin, Chuyi Zhou, Rui Kong, Hao Wang, Binghan Dai, Yannan Xie, Zhiqun Lin   +15 more
wiley   +1 more source

Entorhinal Astrocyte Transplants Restore Spatial Exploration and Alleviate Amyloid‐Beta Pathology in Alzheimer's Mice

Advanced Science, EarlyView.
Impaired MEC astrocytic Ca2+ signaling is associated with fragmented spatial exploration in AD mice. Region‐specific glial progenitor transplantation generates engrafted astrocytes that are accompanied by improved AQP4 polarization, reduced amyloid‐β‐associated pathology, attenuated neuroinflammation, preserved synaptic integrity, and ameliorated ...
Fengjuan Wu, Jihua Fan, Xiang Zhou, Zhiqi Yang, Mingyue Gong, Mingzhu Huang, Zhenlu Cai, Shaofan Yang, Teng Teng, Chuanyan Yang, Jin Li, Haoyu Wang, Shuangshuang Dai, Chunhai Chen, Xiaowei Chen, Manxia Wang, Kuan Zhang   +16 more
wiley   +1 more source

Prognostic implications of adaptive immune features in MMR-proficient colorectal liver metastases classified by histopathological growth patterns. [PDF]

Br J Cancer, 2022
Messaoudi N, Henault D, Stephen D, Cousineau I, Simoneau E, Rong Z, Létourneau R, Plasse M, Dagenais M, Roy A, Lapointe R, Vandenbroucke-Menu F, Kunda R, Ysebaert D, Soucy G, Stagg J, Vermeulen P, Turcotte S.   +17 more
europepmc   +1 more source

USP30‐Mediated Deubiquitination of PEX5 Suppresses Pexophagy to Drive Tubular Injury in Diabetic Kidney Disease

Advanced Science, EarlyView.
USP30 accumulation in diabetic renal tubular epithelial cells deubiquitinates PEX5, suppresses pexophagy, and drives dysfunctional peroxisome accumulation and tubular injury. USP30 depletion restores PEX5 ubiquitination and pexophagy, improves peroxisomal function, and alleviates tubular damage, highlighting USP30 as a therapeutic target in diabetic ...
Jia Li, Chaoyang Hua, Guangpu Li, Furong Zhai, Jingjing Ren, Shaokang Pan, Qi Feng, Jianguo Wen, Dongwei Liu, Zhangsuo Liu, Jiayu Duan   +10 more
wiley   +1 more source

Histopathological assessment of wheat seedling tissues infected by Fusarium pseudograminearum

, 2013
Histopathological assessment of infection by the crown rot pathogen Fusarium pseudograminearum in wheat seedling tissues was performed using fluorescence microscopy. The coleoptiles and leaf sheaths of four host cultivars of differing susceptibility were
Knight, N. L., Sutherland, M. W.
core   +1 more source

A Decoy‐Receptor‐Armed Biomimetic Nanotherapeutic With Inherent Tropism for Conserved Pathogenic Macrophages for Treating Osteoarthritis and Intervertebral Disc Degeneration

Advanced Science, EarlyView.
A biomimetic doppelgänger nanosystem neutralizes extracellular inflammatory cytokines and silences intracellular pyroptosis, reprogramming pathogenic macrophages to attenuate both joint and spine degeneration. ABSTRACT Osteoarthritis (OA) and intervertebral disc degeneration (IVDD) are debilitating musculoskeletal disorders driven by shared ...
Fudong Li, Bin Zhang, Zhiqiu Zhang, Bing Zheng, Linhui Han, Chen Yan, Jialin Li, Kaiqiang Sun, Tianyi Zhao, Jiangang Shi   +9 more
wiley   +1 more source

A Study On The Histopathological Analysis Of Nasal Masses Among Patients Attending The Ent Department Of Pakistan Institute Of Medical Sciences, Islamabad

Journal of Rawalpindi Medical College
Objective: The study was conducted to understand the different histopathological patterns, the classification of nasal tumours, and the relative distribution of the various lesions by age and sex.
Malik Jawad Faisal, Muhammad Arshad, Moniba Zafar, Ahmed Hasan Ashfaq, Syed Fahd Shah   +4 more
doaj   +1 more source