Results 151 to 160 of about 7,049,835 (311)

Matrix metalloproteinase‐9 regulates cell adhesion and membrane protrusive activity of ovarian cancer cells

FEBS Open Bio, EarlyView.
Matrix metalloproteinase‐9 (MMP9) drives ovarian cancer progression. Using MMP9‐null cells (M9‐KO) created from ovarian cancer cells, we found MMP9 loss did not block Epidermal Growth Factor (EGF)‐driven E‐cadherin dissolution or EMT but delayed and reduced EGF‐driven membrane protrusions. Transient MMP9 re‐expression drove membrane protrusion.
Claire Strauel, Sam Bennett, Natalie Ehlinger, Nelson Cook, Katelyn Marvin, Caleb L. Lines, Sam Reyes, Brooke Kirby, Shawn M. Ellerbroek   +8 more
wiley   +1 more source

Quantitative proteomic analysis reveals different characteristics of bladder cancer cells after exposure to bisphenol A

FEBS Open Bio, EarlyView.
Bisphenol A (BPA), a common chemical in plastics, exerts dual effects on bladder cancer cells: low doses promote growth and migration, while high doses suppress growth and migration. Multi‐omics and bioinformatics reveal BPA acts via MAPK and inflammatory pathways.
Shaomin Niu, Lanlan Li, Wenjuan Jia, Hanzhong Feng, Xiaoquan Yu, Youli Zhao, Fengzhi Yuan, Hui Ding, Junqiang Tian, Yong‐Xing He, Zhiping Wang   +10 more
wiley   +1 more source

The Heritage from Cultural Turn to Inclusive Turn. The Cultural and Sacred Landscapes of the UNESCO List: a Sustainable Track to overcome the Dichotomy between Tangible and Intangible Heritage? [PDF]

, 2016
The term ‘heritage’ has considerably changed its meaning over time, especially in recent decades and among contemporary local communities, partially owing to the instruments developed by the UNESCO jointly with the World Heritage Center.
Fiorella Dallari
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Critical Literacy and Socio-Historical and Cultural theory: approaches and reflections on development and constitution of the subject

, 2022
En este artículo buscamos aproximaciones entre la Teoría Socio-Histórico y Cultural (VYGOTSKY, 2007 [1934]; LURIA, 1988, 2012; MOLON, 2011) y la teoría de la Literacidad (KLEIMAN, 1995, 2006; ROJO, 2009; SOARES, 2003; STREET, 2003, 2014; GEE, 1991, 2000), con énfasis en la Literacidad Crítica (CASSANY; CASTELLÀ, 2010; CARBONIERI, 2016; MENEZES DE SOUZA,
openaire   +1 more source

Evolutionarily divergent DUF4465 domains have a common vitamin B12‐binding function

FEBS Open Bio, EarlyView.
We show that DUF4465 family proteins, widespread across bacteria from gut microbiomes, hydrothermal vents, and soil, share a common vitamin B12‐binding function. These augmented β‐jellyroll proteins bind vitamin B12 via extended loops. Our findings establish sequence‐diverse DUF4465 proteins as a widespread class of B12‐binding proteins, highlighting ...
Charlea Clarke, Michal Banasik, Rokas Juodeikis, Martin J. Warren, Richard W. Pickersgill   +4 more
wiley   +1 more source

Suppression of lung adenocarcinoma migration through organelle alkalization by human lactoferrin – albumin fusion

FEBS Open Bio, EarlyView.
This paper reveals how human lactoferrin–albumin fusion (hLF‐HSA) potently suppresses lung adenocarcinoma cell migration. hLF‐HSA upregulates NHE7, leading to Golgi alkalization, disruption of the Golgi secretome, downregulation of MMP1, and reversal of EMT. These findings suggest a novel Golgi‐targeting strategy to suppress cancer cell migration.
Hana Nopia, Masahiro Kimura, Daisuke Kurimoto, Atsushi Sato   +3 more
wiley   +1 more source

Blood‐based proteomic profiling reveals context‐dependent changes in BCL2‐associated signaling during taxane therapy in breast cancer patients

FEBS Open Bio, EarlyView.
Chemotherapy side effects significantly impact cancer survivors' quality of life. Using protein levels in blood samples from breast cancer patients before and after 12 weeks of taxane treatment, we detected treatment‐dependent changes in calcium signaling and aging pathways associated with cancer recurrence.
Saira Munshani, Eiman Y. Ibrahim, Rozalyn L. Rodwin, Leah M. Ferrucci, Kim Blenman, Maryam Lustberg, Barbara E. Ehrlich   +6 more
wiley   +1 more source

Integrating agents and virtual institutions for sharing cultural heritage on the Web

, 2009
This work outlines the research activities carried out by our groups in the direction of the implementation of a tool for sharing natural and cultural heritage on the web. The tool will serve as a support to teachers and people involved in scientific and
Ancona, Massimo, Mascardi, Viviana, Simoff, Simeon J., Traverso, Antonella, Papaleo, Laura, Quercini, Gianluca, Cohen, Alex S., Bogdanovych, Anton   +7 more
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Identifying gene expression signatures for risk stratification of postoperative adjuvant chemotherapy in colorectal cancer

FEBS Open Bio, EarlyView.
A novel signature integrating genome‐wide analysis with clinical factors predicts recurrence in stage II colorectal cancer and enables a new risk stratification to guide postoperative adjuvant chemotherapy. Clinical risk stratification for postoperative recurrence in patients with pathological stage II (pStage II) colorectal cancer (CRC) is essential ...
Mayuko Otomo, Keisuke Okuno, Shuichi Watanabe, Sakiko Oba, Hiroyasu Kagawa, Masanori Tokunaga, Daisuke Ban, Yusuke Kinugasa   +7 more
wiley   +1 more source

Culture and Cognitive Theory: Toward a Reformulation

, 2001
In a provocative and important recent article Anthony Marsella (1998) makes an eloquent plea for the forging of a new metadiscipline of psychology that he labels global-community psychology.
Durrant, Russil, Thakker, Jo
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