Results 151 to 160 of about 194,482 (300)
The article highlights the relevance of the study of the objects of cultural heritage of Ukraine of the post-Hetman period and the descendants of the Ukrainian early modern elite of the late 18th – mid 19th centuries.
Gorenko, L. (Larisa)
core
FEBS Open Bio, EarlyView.Human ABCE1 cannot functionally replace its yeast ortholog. Yeast–human chimera analysis identified NBD1 as a major interspecies barrier. Genetic screening yielded hABCE1 revertants that rescue yeast viability but fail to suppress aberrant translation reinitiation in the 3′ UTR.
Eriko Nakata +3 more
wiley +1 more source
Sustainable urban planning patterns and techniques in historical contextsCase study (Bolaghi neighborhood of Qazvin) [PDF]
تحقیقات کاربردی علوم جغرافیاییHistorical contexts have rich cultural and cultural resources and are not very important not only because of the existence of valuable historical buildings and spaces, but also because they are real narratives of the life and activities of human beings ...
Amir Alimmohamadi +3 more
doaj
Type I interferons modulate autophagy to shape gemcitabine response in pancreatic cancer cells
FEBS Open Bio, EarlyView.Type I interferons differentially modulate autophagy and the response of pancreatic cancer cells to gemcitabine. IFNα2b stimulates autophagic flux and protects cells from gemcitabine‐induced cell death, contributing to chemoresistance. In contrast, IFNβ1a inhibits autophagosome formation and enhances gemcitabine‐induced cell death, resulting in ...
Lucy E. Bonilla +10 more
wiley +1 more source
Selective elimination of quiescent cancer cells by dequalinium chloride via ROS‐mediated ferroptosis
FEBS Open Bio, EarlyView.Dequalinium chloride (DQ) selectively eliminates quiescent cancer cells (QCCs) by amplifying mitochondrial ROS. QCCs exhibit elevated basal ROS and limited redox‐buffering capacity, making them vulnerable to further ROS increases. DQ‐induced ROS exceeds the tolerance threshold, triggering lipid peroxidation and ferroptosis, whereas proliferating cells ...
Kotaro Miyamoto +14 more
wiley +1 more source
CONCEPTUAL APPROACH TO THE DEVELOPMENT OF HISTORICAL AND CULTURAL HERITAGE OF HOTELS
European Science, 2019 openaire +1 more source
The natural-historical and socio-cultural foundations of personal self-identification
, 2014 The article describes some sources of personal self-identification that belong to the sphere of the unconscious and preconceptual, of certain predispositions and potentials, collective memory and traditions.
I I Kvasova
core
The problem of individuals and groups supporting discriminatory attitudes, which is one of the obstacles to the sustainable development of society, is in the field of research attention of psychology, sociology, law and other sciences.
Rail M. Shamionov
core +1 more source
FEBS Open Bio, EarlyView.TGF‐β1 stimulation downregulates lysosomal channel TRPML1 in pulmonary fibroblasts. The TRPML1 agonist ML‐SA5 suppressed fibroblast‐to‐myofibroblast activation and collagen production. Mechanistically, ML‐SA5 inhibited mTOR phosphorylation, restored autophagic flux, and its effects were enhanced by rapamycin (mTOR inhibitor) and reversed by MHY1485 ...
Jiatong Yao +10 more
wiley +1 more source
In vitro generation of regulatory T cells: A challenging tool for studying immune aging in humans
FEBS Open Bio, EarlyView.In vitro induction of human regulatory T cells using standard protocols generates suppressive, Foxp3‐expressing CD4+ T cells independently of TGF‐β supplementation and donor age. Regulatory T (Treg) cells play a key role in immune tolerance and homeostasis.
Lynn Muller +3 more
wiley +1 more source