Results 141 to 150 of about 31,173,191 (303)
Political Theory in the Historical Sciences and Historical Theory in Political Science
CalendaThrough this joint Call for Papers, “Geschichtstheorie am Werk” and “theorieblog”, two blog platforms designed to address basic theoretical questions of their disciplines (history and political science) for a wider audience, invite you to explore how and with what implications historical theory assumptions, historicity concepts and historical ...
openaire +1 more source
Symposium of the Arizona-Nevada Academy of Science (1973)
, 1973 SEVENTEENTH ANNUAL MEETING / May 5, 1973 / Joint Meeting with the Pacific Division of the American Association for the Advancement of Science / University of Arizona / Tucson, ArizonaThis volume is part of the Arizona-Nevada Academy of Science ...
Arizona-Nevada Academy of Science
core
Molecular Oncology, EarlyView.This study shows that lung adenocarcinomas exploit developmental branching morphogenesis to acquire a therapy resistant basal‐like tumour cell state. This process was found to be regulated by combined TP53 loss‐of‐function and type‐I interferon signalling, identifying a novel axis for biomarker and therapeutic target discovery.
Kamila J Bienkowska +13 more
wiley +1 more source
Molecular Oncology, EarlyView.Combining osimertinib with the STING agonist ADU‐S100 activates innate and adaptive immunity to overcome the non‐inflamed microenvironment of Egfr‐mutant lung cancer. This combination increases NK and CD8+ T‐cell infiltration, associated with activation of the STING‐IRF3 pathway and local immunogenic cell death.
Jun Nishimura +19 more
wiley +1 more source
Proceedings of the Arizona-Nevada Academy of Science, Volume 19 (1984)
, 1983 TWENTY EIGHTH ANNUAL MEETING / April 7, 1984 / Joint Meeting with the Pacific Division of the American Association for the Advancement of Science / Participating Societies: Arizona Junior Academy of Science, American Water Resources Association ...
Arizona-Nevada Academy of Science
core
Loss of IGF‐1R impairs DNA‐PKcs recruitment to chromatin leading to defective end‐joining
Molecular Oncology, EarlyView.IGF‐1R promotes radioresistance by facilitating DNA‐PKcs recruitment to chromatin, enabling non‐homologous end‐joining (NHEJ) repair of double‐strand breaks. Inhibition or loss of IGF‐1R disrupts this recruitment to damage sites, driving compensatory reliance on microhomology‐mediated end‐joining (MMEJ) repair.
Matthew O. Ellis +3 more
wiley +1 more source
Proceedings of the Arizona-Nevada Academy of Science, Volume 21 (1986)
, 1986 THIRTIENTH ANNUAL MEETING / April 19, 1986 / Joint Meeting with the Pacific Division of the American Association for the Advancement of Science / Participating Societies: Arizona Junior Academy of Science, American Water Resources Association / Glendale ...
Arizona-Nevada Academy of Science
core
Molecular Oncology, EarlyView.Pair‐wise comparison of the CellSearch and FETCH enrichment technologies for circulating tumor cells (CTCs) from metastatic breast, prostate, and small cell lung cancer patients shows an increased capture of CTCs using FETCH enrichment. The clinical implementation of circulating tumor cells (CTCs) as a predictive tool for therapy efficacy in the ...
Michiel Stevens +6 more
wiley +1 more source
Finding novel vulnerabilities of hypomorphic BRCA1 alleles
Molecular Oncology, EarlyView.Synthetic lethality screens performed to identify novel vulnerabilities often model complete gene loss, thereby overlooking patient‐derived hypomorphic mutations. In this study, we have performed genome‐wide CRISPR screens on BRCA1 hypomorphic mutations, showing BRCA1I26A behaves like wild‐type, while BRCA1R1699Q mimics deficiency. Furthermore, we have
Anne Schreuder +10 more
wiley +1 more source