Results 141 to 150 of about 426,189 (312)
AI, Science, and Intellectual Processes: Preliminary Remarks andArguments
, 1990 This paper argues that trying to answer questions like the precise relationship of AI to existing disciplines (psychology, philosophy, linguistics, etc.) is both premature and potentially harmful to all concerned.
Nutter, J. Terry
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Kuhn, Sarton, and the history of science [PDF]
, 2013 The scientific work of Leonardo da Vinci may have served as the main inspiration for the historical research of George Sarton. Although he never produced a work he felt was worthy of its subject, the little that he did write about Leonardo reveals the ...
Oliveira, Amelia J. +1 more
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Somatic mutational landscape in von Hippel–Lindau familial hemangioblastoma
Molecular Oncology, EarlyView.The causes of central nervous system (CNS) hemangioblastoma in Von Hippel–Lindau (vHL) disease are unclear. We used Whole Exome Sequencing (WES) on familial hemangioblastoma to investigate events that underlie tumor development. Our findings suggest that VHL loss creates a permissive environment for tumor formation, while additional alterations ...
Maja Dembic +5 more
wiley +1 more source
The image of N. M. Karamzin in Russian poetry
Слово.ру: балтийский акцент, 2016 There are virtually no specialized studies into the creation of poetic image of N. Karamzin in late 18th — early 19th centuries in Russian literature; though it is the expressiveness and imagery of poetry which can have a great impact on the myths in ...
Galtsov V.
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Molecular Oncology, EarlyView.Targeted therapy was evaluated in SHH medulloblastoma using neuroepithelial stem cell (NES) and tumor‐derived NES‐like (tNES) models in 2D monolayers and 3D spheroids. PI3K, AKT, and CDK4/6 inhibitors had minimal effects in NES but markedly reduced viability and growth and induced apoptosis in tNES cells, revealing distinct therapeutic vulnerabilities.
Monika Lukoseviciute +4 more
wiley +1 more source
The Kentennial, Newsletter of the Kent Historical Society, Volume 34, March 1999
, 1999 March 1999 A Note from the Director I am pleased to announce the appointment Lisa Mertel as our new Administrative Assistant at Kent Historical Society. Lisa replaces Bev Thome, who left us De- Lisa is a native of Geauga County. She holds a B.A.
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Molecular Oncology, EarlyView.We have established a humanized orthotopic patient‐derived xenograft (Hu‐oPDX) mouse model of high‐grade serous ovarian cancer (HGSOC) that recapitulates human tumor–immune interactions. Using combined anti‐PD‐L1/anti‐CD73 immunotherapy, we demonstrate the model's improved biological relevance and enhanced translational value for preclinical ...
Luka Tandaric +10 more
wiley +1 more source
The State of Computer Science in National Colleges And Universities
, 1983 The author served on the State Council for Higher Education in Virginia (SCHEV) task force on computer science education during the academic year 1983; this report was originally offered as the first chapter in the report of that task force.
Lee, John A. N.
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Hippo pathway at the crossroads of stemness and therapeutic resistance in breast cancer
Molecular Oncology, EarlyView.Dysregulation of the Hippo pathway drives nuclear accumulation of YAP/TAZ, activating stemness‐related transcriptional programs that sustain breast cancer stemness and fuel therapeutic resistance across subtypes, underscoring Hippo signaling as a targetable vulnerability. Figure created and edited with BioRender.com.
Giulia Schiavoni +11 more
wiley +1 more source
The Kent Historian, Kent Historical Society Newsletter, Number 83, Summer/Fall 2014
, 2014 THE KENT HISTORIAN The Newsletter of the Kent Historical Society Summer/Fall 2014 Number83 Mill artifacts at home in Garrett Room exhibit Objects help tell stories of Kent, its residents and its history By Kasha Legeza Burton Kent Historical Society ...
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