Results 101 to 110 of about 1,885,281 (312)

Historical sociology of the city [PDF]

open access: yes, 2003
About the book: This Handbook consists of 26 chapters on historical sociology. It is divided into three parts. Part One is devoted to Foundations and covers Marx, Weber, evolutionary and functionalist approaches, the Annales School, Elias, Nelson and ...
Isin, Engin F.
core  

Mechanisms of IgE‐mediated food allergy and the role of allergen‐specific B cells

open access: yesFEBS Letters, EarlyView.
Food allergy arises when allergen‐specific B cells preferentially produce immunoglobulin E (IgE) antibodies against harmless foods. This article explains the mechanisms driving IgE‐mediated reactions, highlights the central role of these B cells, and discusses how natural tolerance (NT) and oral immunotherapy (OIT) can reshape allergic immune responses.
Juan‐Felipe López   +2 more
wiley   +1 more source

The Learning Sciences in China: Historical Development and Future Trends

open access: yesECNU Review of Education, 2019
Purpose: This study charts the developmental history of the learning sciences (LS) in China and analyzes the direction of its future development. Design/Approach/Methods: An extensive literature review is presented to compile notable events in the ...
Jian Zhao, Xiaozhe Yang
doaj   +1 more source

Transferrin receptor 1‐mediated iron uptake supports thermogenic activation in human cervical‐derived adipocytes

open access: yesFEBS Letters, EarlyView.
In this study, we found that human cervical‐derived adipocytes maintain intracellular iron level by regulating the expression of iron transport‐related proteins during adrenergic stimulation. Melanotransferrin is predicted to interact with transferrin receptor 1 based on in silico analysis.
Rahaf Alrifai   +9 more
wiley   +1 more source

The Sikhs – religion and nation. Chosen political and social determinants of functioning

open access: yesStudia z Geografii Politycznej i Historycznej, 2019
The article attempts to estimate the influence of the geographical and political conditions on the transformation of a Sikhs community after the decolonisation of India in 1947.
Marek Barwiński, Łukasz Musiaka
doaj   +1 more source

Foundation Funding for the Humanities: An Overview of Current and Historical Trends [PDF]

open access: yes, 2004
Foundation Funding for the Humanities: An Overview of Current and Historical Trends, finds that funding for fields such as art history, history and archeology, languages and linguistics, area studies, and the humanistic social sciences increased two and ...
Loren Renz, Steven Lawrence
core  

Tau acetylation at K331 has limited impact on tau pathology in vivo

open access: yesFEBS Letters, EarlyView.
We mapped tau post‐translational modifications in humanized MAPT knock‐in mice and in amyloid‐bearing double knock‐in mice. Acetylation within the repeat domain, particularly around K331, showed modest increases under amyloid pathology. To test functional relevance, we generated MAPTK331Q knock‐in mice.
Shoko Hashimoto   +3 more
wiley   +1 more source

Preotul Gheorghe I. Cotenescu (1886-1965), protopsalt, profesor, compozitor, dirijor, publicist şi om politic [PDF]

open access: yesStudii si Cercetari de Istoria Artei : Teatru, Muzică, Cinematografie, 2015
The intellectual portrait of Father Gheorghe I. Cotenescu sketched out in this essay performs a dual function. While paying tribute to the work and fate of a neglected, but fascinating inter-war scholar, it serves as a tool which allows us to focus on ...
Radu Petrescu
doaj  

Calpain small subunit homodimerization is robust and calcium‐independent

open access: yesFEBS Letters, EarlyView.
Calpains dimerize via penta‐EF‐hand (PEF) domains. Using single‐molecule force spectroscopy, we measured the strength and kinetics of PEF–PEF homodimer binding. The interaction is robust, shows a transient conformational step before dissociation, and remains largely insensitive to Ca2+.
Nesha May O. Andoy   +4 more
wiley   +1 more source

Structural insights into an engineered feruloyl esterase with improved MHET degrading properties

open access: yesFEBS Letters, EarlyView.
A feruloyl esterase was engineered to mimic key features of MHETase, enhancing the degradation of PET oligomers. Structural and computational analysis reveal how a point mutation stabilizes the active site and reshapes the binding cleft, expading substrate scope.
Panagiota Karampa   +5 more
wiley   +1 more source

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