Results 101 to 110 of about 432,891 (284)

The (Glg)ABCs of cyanobacteria: modelling of glycogen synthesis and functional divergence of glycogen synthases in Synechocystis sp. PCC 6803

open access: yesFEBS Letters, EarlyView.
We reconstituted Synechocystis glycogen synthesis in vitro from purified enzymes and showed that two GlgA isoenzymes produce glycogen with different architectures: GlgA1 yields denser, highly branched glycogen, whereas GlgA2 synthesizes longer, less‐branched chains.
Kenric Lee   +3 more
wiley   +1 more source

Site-Specific Installation Art in Historical Perspective

open access: yes, 2021
The argument in this chapter starts with a discussion of the art historical discourse on site-specific installation art. Artists as well as critics have explored various notions of site specificity, usually in concordance with successive art historical periods: the first “wave” of site-specific installations created during the late ...
openaire   +1 more source

The Constitution of Social Practices [PDF]

open access: yes, 2017
Practices – specific, recurrent types of human action and activity – are perhaps the most fundamental "building blocks" of social reality. This book argues that the detailed empirical study of practices is essential to effective social-scientific ...
McMillan, Kevin
core  

Organ‐specific redox imbalances in spinal muscular atrophy mice are partially rescued by SMN antisense oligonucleotides

open access: yesFEBS Letters, EarlyView.
We identified a systemic, progressive loss of protein S‐glutathionylation—detected by nonreducing western blotting—alongside dysregulation of glutathione‐cycle enzymes in both neuronal and peripheral tissues of Taiwanese SMA mice. These alterations were partially rescued by SMN antisense oligonucleotide therapy, revealing persistent redox imbalance as ...
Sofia Vrettou, Brunhilde Wirth
wiley   +1 more source

Personal Names of Vilnius Residents in the 16th–17th Centuries

open access: yesOnomástica desde América Latina
Documents of municipal self-government institutions are among the most important historical anthroponymy sources of the Lithuanian burgher estate.
Alma Ragauskaitė
doaj   +1 more source

β‐TrCP overexpression enhances cisplatin sensitivity by depleting BRCA1

open access: yesMolecular Oncology, EarlyView.
Low levels of β‐TrCP (Panel A) allow the accumulation of BRCA1 and CtIP, which facilitate the repair of cisplatin‐induced DNA damage via homologous recombination (HR) and promote tumor cell survival. In contrast, high β‐TrCP expression (Panel B) leads to BRCA1 and CtIP degradation, impairing HR repair, resulting in persistent DNA damage and apoptosis ...
Rocío Jiménez‐Guerrero   +8 more
wiley   +1 more source

PARP inhibitors elicit distinct transcriptional programs in homologous recombination competent castration‐resistant prostate cancer

open access: yesMolecular Oncology, EarlyView.
PARP inhibitors are used to treat a small subset of prostate cancer patients. These studies reveal that PARP1 activity and expression are different between European American and African American prostate cancer tissue samples. Additionally, different PARP inhibitors cause unique and overlapping transcriptional changes, notably, p53 pathway upregulation.
Moriah L. Cunningham   +21 more
wiley   +1 more source

Noël Carroll : eine Bibliographie [PDF]

open access: yes, 2010
Das Werk des Philosophen und Filmtheoretikers Noël Carroll ist außerordentlich vielgestaltig, über mehrere Disziplinen verstreut, umfaßt allgemeine Arbeiten zur ästhetischen Theorie (auf diesem Gebiet ist Carroll vor allem in den letzten Jahren aktiv ...
Wulff, Hans Jürgen
core  

Characterizing the salivary RNA landscape to identify potential diagnostic, prognostic, and follow‐up biomarkers for breast cancer

open access: yesMolecular Oncology, EarlyView.
This study explores salivary RNA for breast cancer (BC) diagnosis, prognosis, and follow‐up. High‐throughput RNA sequencing identified distinct salivary RNA signatures, including novel transcripts, that differentiate BC from healthy controls, characterize histological and molecular subtypes, and indicate lymph node involvement.
Nicholas Rajan   +9 more
wiley   +1 more source

I confini di Urania. La geografia come limes perdurante [PDF]

open access: yesDiacronie. Studi di Storia Contemporanea, 2009
The notion of “inner boundary” is the key point in understanding the internal dynamics of independence and autonomy movements that have made ​​their appearance in Corsica and Sicily during the nineteenth and twentieth centuries.
Deborah Paci
doaj  

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