Results 91 to 100 of about 24,860,034 (345)

Cytopathic Mechanisms of HIV-1 [PDF]

Virology Journal, 2007
The human immunodeficiency virus type 1 (HIV-1) has been intensely investigated since its discovery in 1983 as the cause of acquired immune deficiency syndrome (AIDS). With relatively few proteins made by the virus, it is able to accomplish many tasks, with each protein serving multiple functions.
openaire   +4 more sources

Engineered Plasmonic and Fluorescent Nanomaterials for Biosensing, Motion, Imaging, and Therapeutic Applications

Advanced Materials, EarlyView.
A schematic illustration of how noble metals can be used to create nanoparticles (NPs) or nanoclusters (NCs). Noble metal NPs, due to their plasmonic properties, enable photothermal therapy and surface‐enhanced Raman scattering (SERS). In contrast, NCs, which lack a plasmonic resonance band, exhibit fluorescence, making them ideal for bioimaging ...
David Esporrín‐Ubieto, Juan C. Fraire, Daniel Sánchez‐deAlcázar, Samuel Sánchez   +3 more
wiley   +1 more source

A novel quantitative approach for measuring the reservoir of latent HIV-1 proviruses

Nature, 2019
A stable latent reservoir for HIV-1 in resting CD4+ T cells is the principal barrier to a cure1–3. Curative strategies that target the reservoir are being tested4,5 and require accurate, scalable reservoir assays.
Katherine M. Bruner, Z. Wang, F. Simonetti, A. Bender, K. J. Kwon, Srona Sengupta, E. Fray, Subul A. Beg, A. Antar, K. Jenike, Lynn N. Bertagnolli, A. Capoferri, J. Kufera, Andrew E Timmons, Christopher L. Nobles, J. Gregg, N. Wada, Y. Ho, Hao Zhang, J. Margolick, J. Blankson, S. Deeks, F. Bushman, J. Siliciano, G. Laird, R. Siliciano   +25 more
semanticscholar   +1 more source

Implantable Microarray Patch: Engineering at the Nano and Macro Scale for Sustained Therapeutic Release via Synthetic Biodegradable Polymers

Advanced Materials Technologies, Volume 10, Issue 6, March 18, 2025.
This review focuses on the application of synthetic biodegradable microarray patches (MAPs) in sustained drug delivery. Compared to conventional MAPs which release drugs into the skin in an immediate manner, these implantable MAPs release drugs into skin microcirculation gradually as the biodegradable polymers degrade, thus offering sustained release ...
Li Zhao, Akmal Hidayat Bin Sabri, Mary B. McGuckin, Linlin Li, Zihao Wang, Eneko Larrañeta, Ryan F. Donnelly   +6 more
wiley   +1 more source

HIV-1 detection in the olfactory mucosa of HIV-1-infected participants

AIDS, 2019
HIV infection chronically affects the central nervous system (CNS). Olfactory mucosa is a unique site in the respiratory tract that is directly connected to the CNS; thus we wanted to evaluate olfactory mucosa as a surrogate of CNS sampling.We conducted a preliminary study examining HIV populations and susceptible cells in the olfactory mucosa ...
Bertero, Luca, Joseph, Sarah Beth, Trunfio, Mattia, Allice, Tiziano, Catera, Sebastiano, Imperiale, Daniele, Cassoni, Paola, Kincer, Laura Pesci, Pirriatore, Veronica, Ghisetti, Valeria, Amasio, Enrica, Zanusso, Gianluigi, Bonora, Stefano, Di Perri, Giovanni, Calcagno, Andrea   +14 more
openaire   +5 more sources

Nanomaterial‐Based Optical Biosensors for SARS‐CoV‐2 Detection: A Retrospective of the Pandemic

Advanced Sensor Research, EarlyView.
This review discusses nanomaterial‐based optical biosensors developed for or adapted to the detection of severe acute respiratory syndrome coronavirus 2 (SARS‐CoV‐2). It concludes by providing a perspective on how lessons learned during the coronavirus disease of 2019 (COVID‐19) pandemic may be applied for future research on nanomaterial‐based ...
Flavie Martin, Scott G. Harroun, Michel Meunier   +2 more
wiley   +1 more source

Digital Bioassays on the Slipchip Microfluidic Devices

Advanced Sensor Research, EarlyView.
This review summarizes recent advances in SlipChip‐based digital bioassays, highlighting their simple “load and slip” operation for fluid partitioning which eliminate the need for sophisticated fluidic systems. Applications include digital nucleic acid analysis, digital protein analysis and single‐cell analysis, demonstrating the platform‘s potential ...
Qingqing Luo, Ziqing Yu, Weiyuan Lyu, Yang Luo, Lei Xu, Feng Shen   +5 more
wiley   +1 more source

Editorial: The relevance of molecular mechanisms in HIV-1 latency and reactivation from latency

Frontiers in Cellular and Infection Microbiology, 2023
Alexander O. Pasternak, Olivier Rohr, Olivier Rohr, Carine Van Lint, Anna Kula-Pacurar   +4 more
doaj   +1 more source

Early Therapy in HIV-1-Infected Children: Effect on HIV-1 Dynamics and HIV-1-Specific Immune Response

Antiviral Therapy, 2008
Background Perinatal HIV-1 infection is acquired in the milieu of a developing immune system, leading to high levels of uncontrolled viral replication. Few data have been reported that address the viral dynamics and immunological response in infants who initiated aggressive antiretroviral therapy (ART) shortly after birth.
M. Zanchetta, A. Anselmi, D. Vendrame, O. Rampon, C. Giaquinto, A. Mazza, ACCAPEZZATO, DANIELE, BARNABA, Vincenzo, A. De Rossi   +8 more
openaire   +5 more sources

Mechanical Interactions Impact the Functions of Immune Cells and Their Application in Immunoengineering

Advanced Therapeutics, EarlyView.
This review covers the mechanical forces experienced by immune cells through cell–cell and cell–extracellular matrix interactions and how these forces influence their receptors and functions. These relationships between forces and cellular functions can be exploited using engineering techniques to modify the physical properties of materials for novel ...
Yu‐Chang Chen, Nghi M. Tran, Kyle H. Vining   +2 more
wiley   +1 more source