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VirusesThe human immunodeficiency virus type 1 (HIV-1) epidemic has been a major public health threat on a global scale since the early 1980s. Despite the introduction of combination antiretroviral therapy (cART), the incidence of new HIV-1 infections continues
Cicek Topcu +6 more
doaj +1 more source
Establishment and stability of the latent HIV-1 DNA reservoir [PDF]
arXiv, 2016 HIV-1 infection currently cannot be cured because the virus persists as integrated proviral DNA in long-lived cells despite years of suppressive antiretroviral therapy (ART). To characterize establishment, turnover, and evolution of viral DNA reservoirs we deep-sequenced the p17gag region of the HIV-1 genome from samples obtained after 3-18 years of ...
arxiv
Advanced Science, EarlyView.This study shows that the classical secretory protein S100 calcium‐binding protein A9 (S100A9) can translocate to the nucleus upon de‐phosphorylation at Thr 113 in human amnion fibroblasts at parturition, where S100A9 induces heterochromatin erosion through segregation of the heterochromatin maintenance protein, resulting inLong Interspersed Nuclear ...
Fan Zhang +8 more
wiley +1 more source
Supplemental Data: Stochastic Gene Expression in a Lentiviral Positive Feedback Loop: HIV-1 Tat Fluctuations Drive Phenotypic Diversity [PDF]
arXiv, 2006 Supplemental data for "Stochastic Gene Expression in a Lentiviral Positive Feedback Loop: HIV-1 Tat Fluctuations Drive Phenotypic Diversity" [q-bio.MN/0608002, Cell. 2005 Jul 29;122(2):169-82].
arxiv
Advanced Science, EarlyView.The MoSMAR‐chip platform provides a high‐throughput and cost‐effective tool for identifying and characterizing antigen‐specific antibody‐secreting cells (ASCs) and memory B cells (MBCs) at the single‐cell level. The ASCs from coronavirus disease 2019 (COVID‐19) vaccine‐immunized mice were successfully analyzed, revealing diverse neutralizing antibodies
Tian Zhao +13 more
wiley +1 more source
Geometry of Liquid Crystals and the alignment of HIV-1 virus helical filaments [PDF]
arXiv, 2007 Geometry of Liquid crystals as detectors of HIV twisted helical filaments is presented.
arxiv
Cytopathic Mechanisms of HIV-1 [PDF]
Virology Journal, 2007 The human immunodeficiency virus type 1 (HIV-1) has been intensely investigated since its discovery in 1983 as the cause of acquired immune deficiency syndrome (AIDS). With relatively few proteins made by the virus, it is able to accomplish many tasks, with each protein serving multiple functions.
openaire +4 more sources
Advanced Science, EarlyView.The upregulation of FTO in autoimmune dry eye suppresses the recognition of pri‐miR‐31 by DGCR8, thereby inhibiting the maturation of miR‐31‐5p and reducing its inhibitory effect on the target gene P2RX7. The activation of P2RX7 subsequently triggers the p38 MAPK signaling pathway and increases the level of M1‐related genes, thus exacerbating the ...
Lu Zhao +10 more
wiley +1 more source
Prevalence of HIV Transmitted Drug Resistance in Nanjing from 2018 to 2021
Infection and Drug Resistance, 2023 Yifan Su,1 Mingxue Qi,1 Mingli Zhong,2 Nawei Yu,1 Chen Chen,1 Zi Ye,1 Cong Cheng,1 Zhiliang Hu,1 Hongying Zhang,3 Hongxia Wei1 1Department of Infectious Disease, The Second Hospital of Nanjing Affiliated to Nanjing University of Chinese Medicine, Nanjing,
Su Y +9 more
doaj
How conformational changes can affect catalysis, inhibition and drug resistance of enzymes with induced-fit binding mechanism such as the HIV-1 protease [PDF]
, 2013 A central question is how the conformational changes of proteins affect their function and the inhibition of this function by drug molecules. Many enzymes change from an open to a closed conformation upon binding of substrate or inhibitor molecules.
arxiv +1 more source