Results 91 to 100 of about 25,225,361 (379)

Next‐Generation Bio‐Reducible Lipids Enable Enhanced Vaccine Efficacy in Malaria and Primate Models

Advanced Functional Materials, EarlyView.
Structure–activity relationship (SAR) optimization of bio‐reducible ionizable lipids enables the development of highly effective lipid nanoparticle (LNP) mRNA vaccines. Lead LNPs show superior tolerability and antibody responses in rodents and primates, outperforming approved COVID‐19 vaccine lipids.
Ruben De Coen, Sabah Kasmi, Shrinivas Dumbre, Lies Baekens, Elise Seynaeve, Louise Van den Hauwe, Niccolò Cantini, Aello Garantoudi, Filipe Branco Madeira, Alain Marrot, Emma Tuypens, Sofie Seghers, Anna Kuchmiy, Elisabeth Brabants, Bart Vanderborght, Ine Maes, Sarah Vandenberghe, Jessica Filtjens, Alícia Gordún Peiró, Daliya Kancheva, Ayla Debraekeleer, Florence Lambolez, Emily De Lombaerde, Yong Chen, Rafael Miyazawa Martins, Pauline Formaglio, Damya Laoui, Sofie Deschoemaeker, Bruno G. De Geest, Rogerio Amino, Stefaan De Koker   +30 more
wiley   +1 more source

Development of a droplet digital polymerase chain reaction assay for the sensitive detection of total and integrated HIV-1 DNA

Chinese Medical Journal
. Background:. Total human immunodeficiency virus (HIV) DNA and integrated HIV DNA are widely used markers of HIV persistence. Droplet digital polymerase chain reaction (ddPCR) can be used for absolute quantification without needing a standard curve ...
Lin Yuan, Zhiying Liu, Xin Zhang, Feili Wei, Shan Guo, Na Guo, Lifeng Liu, Zhenglai Ma, Yunxia Ji, Rui Wang, Xiaofan Lu, Zhen Li, Wei Xia, Hao Wu, Tong Zhang, Bin Su, Yanjie Yin   +16 more
doaj   +1 more source

Pharmacological suppression of glycogen synthase kinase-3 reactivates HIV-1 from latency via activating Wnt/β-catenin/TCF1 axis in CD4+ T cells

Emerging Microbes and Infections, 2022
HIV-1 latency posts a major obstacle for HIV-1 eradication. Currently, no desirable latency reversing agents (LRAs) have been implicated in the “Shock and Kill” strategy to mobilize the latently infected cells to be susceptible for clearance by immune ...
Jing Wen, Xin Li, Qing-Xia Zhao, Xiao-Fan Yang, Meng-Li Wu, Qihong Yan, Junbiao Chang, Haikun Wang, Xia Jin, Xiao Su, Kai Deng, Ling Chen, Jian-Hua Wang   +12 more
doaj   +1 more source

The HIV-1 Vaccine Race [PDF]

Cell, 2002
There is an urgent need to come up with a vaccine that will curtail the spread of HIV-1. To be successful, the scientific community must work in concert to develop sound strategies based on a deeper understanding of the virus. Significant technological advances are also required to overcome the unique obstacles posed by HIV-1. Some of the challenges we
Yaoxing Huang, David D. Ho
openaire   +3 more sources

Highly Customizable Scaffold‐Type 3D Microelectrode Array Platform for Design and Analysis of the 3D Neuronal Network In Vitro

Advanced Functional Materials, EarlyView.
An innovative fabrication platform for 3D microelectrode arrays (MEAs) is presented, utilizing a 3D printer and the capillary action of electrically conductive inks. This approach enables the simple and versatile fabrication of 3D MEAs with complex structures.
Dongjo Yoon, Yoonkey Nam
wiley   +1 more source

Study protocol for assessment of the efficacy of calcium dobesilate versus placebo on SARS-CoV-2 viral load in outpatients with COVID-19 (CADOVID study): a randomised, placebo-controlled, double-blind, monocentric phase II trial

BMJ Open
Introduction SARS-CoV-2 mainly infects respiratory endothelial cells, which is facilitated through its spike protein binding to heparan sulphate. Calcium dobesilate (CaD) is a well-established, widely available vasoactive and angioprotective drug ...
Idris Guessous, Alexandra Calmy, Herve Spechbach, Julien Salamun, Tamara Da Silva, Pilar Ustero, Yvan Gosmain   +6 more
doaj   +1 more source

SnapShot: HIV-1 Proteins [PDF]

Cell, 2008
4 to 35 trimersTM Binds cell-surface receptors; mediates virus attachment and entry CD4 CD4 plus CCR5/CXCR4 mediate virion entry; major determinants of viral tropismChemokine receptors (CCR5 and CXCR4)C-type lectin receptors (DC-SIGN, Langerin) Virion capture; viral transmission from dendritic cells to T ...
Michael H. Malim, Chad M. Swanson
openaire   +2 more sources

At‐Home Early Diagnosis of Mastitis: Calibration‐Free Analysis of Sodium to Potassium Ratio in Breast Milk

Advanced Functional Materials, EarlyView.
MAMAWEL is introduced as the first calibration‐free potentiometric sensor for at‐home mastitis diagnosis. By measuring the sodium‐to‐potassium ratio in breast milk, the device reliably differentiates between healthy and mastitis‐affected samples with less than 10% error.
Ali Soleimani, Farbod Amirghasemi, Melissa Banks, Abdulrahman Al‐Shami, Sina Khazaee Nejad, Abdalrhman Sheer, Clare Dominique Sanchez, Haozheng Ma, Daniel Vargas Ramos, Maral P.S. Mousavi   +9 more
wiley   +1 more source

1,2,4-Triazolo[1,5-a]pyrimidines as a Novel Class of Inhibitors of the HIV-1 Reverse Transcriptase-Associated Ribonuclease H Activity

Molecules, 2020
Despite great efforts have been made in the prevention and therapy of human immunodeficiency virus (HIV-1) infection, however the difficulty to eradicate latent viral reservoirs together with the emergence of multi-drug-resistant strains require the ...
Jenny Desantis, Serena Massari, Angela Corona, Andrea Astolfi, Stefano Sabatini, Giuseppe Manfroni, Deborah Palazzotti, Violetta Cecchetti, Christophe Pannecouque, Enzo Tramontano, Oriana Tabarrini   +10 more
doaj   +1 more source

Enhanced target cell specificity and uptake of lipid nanoparticles using RNA aptamers and peptides

Beilstein Journal of Organic Chemistry, 2021
Lipid nanoparticles (LNPs) constitute a facile and scalable approach for delivery of payloads to human cells. LNPs are relatively immunologically inert and can be produced in a cost effective and scalable manner.
Roslyn M. Ray, Anders Højgaard Hansen, Maria Taskova, Bernhard Jandl, Jonas Hansen, Citra Soemardy, Kevin V. Morris, Kira Astakhova   +7 more
doaj   +1 more source