Results 111 to 120 of about 24,860,034 (345)

Tumor necrosis factor stimulates transcription of HIV-1 in human T lymphocytes, independently and synergistically with mitogens. [PDF]

, 1989
Nicole Israël, Uriel Hazan, José Alcamı́, A. Munier, F Arenzana-Seisdedos, Françoise Bachelerie, Alain Israël, J L Virelizier   +7 more
openalex   +1 more source

Advances in Single‐Cell Sequencing for Infectious Diseases: Progress and Perspectives

Advanced Science, EarlyView.
Single‐cell sequencing technologies uncover novel, unknown, and emergent features of many diseases. This review describes recent progress of single‐cell sequencing technologies and their applications in infectious diseases, summarizes the underlying commonalities of different infections and discusses future research directions, facilitating the ...
Mengyuan Lyu, Yang Liu, Jian Zhou, Hongli Lai, Hongxia Ruan, Dongsheng Wu, Shun Zhu, Xudong Zhou, Wananqi Ma, Yuchen Huang, Shuting Lei, Han Luo, Jie Chen, Binwu Ying   +13 more
wiley   +1 more source

(Q)SAR Models of HIV-1 Protein Inhibition by Drug-Like Compounds

Molecules, 2019
Despite the achievements of antiretroviral therapy, discovery of new anti-HIV medicines remains an essential task because the existing drugs do not provide a complete cure for the infected patients, exhibit severe adverse effects, and lead to the ...
Leonid A. Stolbov, Dmitry S. Druzhilovskiy, Dmitry A. Filimonov, Marc C. Nicklaus, Vladimir V. Poroikov   +4 more
doaj   +1 more source

In vitro formation of short RNA polymerase II transcripts that terminate within the HIV-1 and HIV-2 promoter-proximal downstream regions. [PDF]

, 1989
M G Toohey, Katherine A. Jones
openalex   +1 more source

Use of a Vaginal Ring Containing Dapivirine for HIV-1 Prevention in Women.

New England Journal of Medicine, 2016
BACKGROUND Antiretroviral medications that are used as prophylaxis can prevent acquisition of human immunodeficiency virus type 1 (HIV-1) infection.
J. Baeten, T. Palanee-Phillips, E. Brown, Katie D. Schwartz, L. Soto‐torres, Vaneshree Govender, N. Mgodi, Flavia Matovu Kiweewa, G. Nair, F. Mhlanga, Samantha Siva, L. Bekker, Nitesha Jeenarain, Z. Gaffoor, F. Martinson, B. Makanani, Arendevi Pather, Logashvari Naidoo, Marla J. Husnik, B. Richardson, U. Parikh, J. Mellors, M. Marzinke, C. Hendrix, A. van der Straten, G. Ramjee, Z. Chirenje, C. Nakabiito, T. Taha, Judith G. Jones, Ashley J. Mayo, Rachel Scheckter, Jennifer Berthiaume, E. Livant, Cindy E. Jacobson, P. Ndase, Rhonda R White, K. Patterson, Donna Germuga, Beth Galaska, K. Bunge, Devika Singh, D. Szydlo, E. Montgomery, B. Mensch, Kristine Torjesen, Cynthia I. Grossman, N. Chakhtoura, A. Nel, Z. Rosenberg, I. McGowan, S. Hillier   +51 more
semanticscholar   +1 more source

LEDGF Binds H3R17me2a Promoting De Novo Nucleotide Biosynthesis in SETD2 Mutant Clear Cell Renal Cell Carcinoma

Advanced Science, EarlyView.
In SETD2‐mutant ccRCC, the original LEDGF recognition of the H3K36me3 regulatory axis no longer exists. LEDGF interacts with CARM1‐dependent H3R17me2a regulating the transcription of key enzymes in the de novo synthesis pathway. The abnormally elevated LEDGF leads to the accumulation of purine nucleotides in SETD2‐mutant ccRCC, thereby satisfying the ...
Yuwei Zhang, Yuhua Zhou, Yuezhou Zhang, Jing Lv, Yang Shen, Dong Zhang, Bo Liu, Wei Zhao, Junyi Ju, Qingyi Zhu, Ke Wang, Ninghan Feng   +11 more
wiley   +1 more source

HIV-1 Drug Resistance in ART-Naïve Individuals in Myanmar

Infection and Drug Resistance, 2020
Mei Ye,1,2 Xin Chen,1,3 Yu Wang,4 Yan-Heng Zhou,5 Wei Pang,1 Chiyu Zhang,6 Yong-Tang Zheng1,4 1Key Laboratory of Animal Models and Human Disease Mechanisms of the Chinese Academy of Sciences/Key Laboratory of Bioactive Peptides of Yunnan Province, KIZ ...
Ye M, Chen X, Wang Y, Zhou YH, Pang W, Zhang C, Zheng YT   +6 more
doaj  

Several antigenic determinants exposed on the gp120 moiety of HIV-1 gp160 are hidden on the mature gp120. [PDF]

, 1989
Clotilde Thiriart, M Francotte, J. Cohen, Catherine Collignon, Anne Delers, SUZY KUMMERT, Chantal Molitor, D Gilles, P. Roelants, F. van Wijnendaele   +9 more
openalex   +1 more source

A new ensemble coevolution system for detecting HIV-1 protein coevolution

Biology Direct, 2015
A key challenge in the field of HIV-1 protein evolution is the identification of coevolving amino acids at the molecular level. In the past decades, many sequence-based methods have been designed to detect position-specific coevolution within and between
Guangdi Li, Kristof Theys, J. Verheyen, A. Pineda-Peña, R. Khouri, Supinya Piampongsant, M. Eusébio, J. Ramon, A. Vandamme   +8 more
semanticscholar   +1 more source

Integrative Single‐Cell Analysis Reveals Iron Overload‐Induced Senescence and Metabolic Reprogramming in Ovarian Endometriosis‐Associated Infertility

Advanced Science, EarlyView.
Iron overload in ovarian endometriosis (OE) disrupts follicular function and contributes to infertility. This study maps iron‐induced cellular changes using single‐cell and spatial transcriptomics, revealing senescence phenotypes in OE patients and mouse models. Similar patterns are observed in aging ovaries, highlighting iron metabolism as a potential
Yangshuo Li, Wei Zhou, Jie Ding, Di Song, Wen Cheng, Jin Yu, Shuai Sun, Shanshan Mei, Xiaolan Liang, Qianqian Zhao, Yanping Kuang, Mingqing Li, Zhexin Ni, Chaoqin Yu, Yue Gao   +14 more
wiley   +1 more source