Results 111 to 120 of about 658,368 (320)
Polymerase/nicking enzyme powered dual-template multi-cycled G-triplex machine for HIV-1 determination [PDF]
arXiv, 2020 We proposed a dual-template multi-cycled DNA nanomachine driven by polymerase nicking enzyme with high efficiency. The reaction system simply consists of two templates (T1, T2) and two enzymes (KF polymerase, Nb.BbvCI). The two templates are similar in structure (X-X-Y, Y-Y-C): primer recognition region, primer analogue generation region, output region
arxiv
Advanced Science, EarlyView.This study uncovers that CD38high monocytes discriminate sepsis and sterile inflammation and are associated with 28‐day mortality in bacterial sepsis. Targeting CD38 therapy reduces inflammatory response in monocytes and in sepsis mice model. Mechanistically, CD38‐HIF‐1α/glycolysis/MGO loop exacerbates sepsis‐induced immune dysregulation.
Ning Hua +19 more
wiley +1 more source
Frontiers in Cellular and Infection Microbiology, 2023 Alexander O. Pasternak +4 more
doaj +1 more source
HIV-1 Drug Resistance in ART-Naïve Individuals in Myanmar
Infection and Drug Resistance, 2020 Mei Ye,1,2 Xin Chen,1,3 Yu Wang,4 Yan-Heng Zhou,5 Wei Pang,1 Chiyu Zhang,6 Yong-Tang Zheng1,4 1Key Laboratory of Animal Models and Human Disease Mechanisms of the Chinese Academy of Sciences/Key Laboratory of Bioactive Peptides of Yunnan Province, KIZ ...
Ye M +6 more
doaj
Journal of Enzyme Inhibition and Medicinal Chemistry, 2020 Lens-epithelium-derived growth-factor (LEDGF/p75)-binding site on HIV-1 integrase (IN), is an attractive target for antiviral chemotherapy. Small-molecule compounds binding to this site are referred as LEDGF-IN inhibitors (LEDGINs).
Da-Wei Zhang +6 more
doaj +1 more source
Impact of delay on HIV-1 dynamics of fighting a virus with another virus [PDF]
arXiv, 2014 In this paper, we propose a mathematical model for HIV-1 infection with intracellular delay. The model examines a viral-therapy for controlling infections through recombining HIV-1 virus with a genetically modified virus. For this model, the basic reproduction number $\mathcal{R}_0$ are identified and its threshold properties are discussed.
arxiv
Dynamic Cap‐Mediated Substrate Access and Potent Inhibitor Design of Monkeypox Virus I7L Protease
Advanced Science, EarlyView.The first crystal structure of MPXV I7L protease, revealing its unique dimeric form is resolved. The structures and MD simulations uncovered a dynamic cap region that regulates substrate access to the active site. The structural basis of substrate recognition and the catalytic mechanism are elucidated, which led to the development of a FRET‐based assay
Haixia Su +12 more
wiley +1 more source
Viruses, 2019 Background: HIV-1 transmitted/founder viruses (TF) are selected during the acute phase of infection from a multitude of virions present during transmission.
Alexis Kafando +11 more
doaj +1 more source
Origins of the Aids Viruses, Hiv-1 and Hiv-2: Fact or Fiction? Discussion Paper [PDF]
, 1988 John Seale
openalex +1 more source
Cell, 2014 HIV-1 virion assembly at the plasma membrane requires the selective recruitment of the viral RNA genome into nascent viral particles while cellular transcripts are excluded. Kutluay et al. now demonstrate that this is a two-step process in which Gag binds sequentially to different sites on the viral genome.
openaire +3 more sources