Results 181 to 190 of about 31,026,669 (309)

Enrichment of the TRIM21-IgG complex in placental villi during HIV-1 infection. [PDF]

Front Immunol
Campo BN, de Sousa ESA, Pereira NZ, Pietrobon AJ, Milanez HMBPM, Sotto MN, Mattos GD, Simões GB, Sousa DP, Naresse MM, Leal VNC, Sato MN.   +11 more
europepmc   +1 more source

Zuranolone: A case study in (regulatory) rush to judgement?

British Journal of Clinical Pharmacology, EarlyView.
Abstract Sage, in collaboration with Biogen, submitted a new drug approval for zuranolone for postpartum depression (PPD) and major depressive disorder (MDD) in December 2022. In August 2023, the US Food and Drug Administration granted approval for PPD but denied approval for MDD.
Lisa Cosgrove, Milutin Kostic, Barbara Mintzes, Gianna D'Ambrozio, Allen Shaughnessy   +4 more
wiley   +1 more source

Hydroxylation of the HIV-1 antisense protein promotes immune evasion of HIV-1 via modulation of TBK1. [PDF]

Nat Commun
Lin X, Zhang W, Li M, Zhang C, Xun J, Han W, Chen J, Zhang Y, Yan D.   +8 more
europepmc   +1 more source

Do drugs approved via expedited approval pathways have therapeutic advantages? A systematic review and meta‐analysis

British Journal of Clinical Pharmacology, EarlyView.
Regulators use expedited approval pathways to speed market approval and patient access to promising new drugs. However, there is uncertainty about whether these pathways are successful in approving drugs with significant therapeutic advantages. This systematic review aims to examine the safety, effectiveness and cost‐effectiveness of drugs approved via
Ashleigh Hooimeyer, Eliza J. McEwin, Zhicheng Wang, Joel Lexchin, Barbara Mintzes   +4 more
wiley   +1 more source

Epigenetic regulation of HIV-1 transcription: insights into latency mechanisms and therapeutic strategies. [PDF]

Front Cell Infect Microbiol
Yang S, Yuan J, Sun X, Huan C.
europepmc   +1 more source

Precision medicine in paediatrics: Progress and priorities

British Journal of Clinical Pharmacology, EarlyView.
Precision medicine is revolutionizing personalized healthcare, advancing both diagnostics and therapeutics at an unprecedented pace. Reviewing the paediatric applications of pharmacometrics, pharmacogenomics and advanced therapy medicinal products highlights not only the relevance of these exciting innovations to frontline care but also the significant
Nicola Husain, Claire Booth, Joseph F. Standing, Charlotte I. S. Barker   +3 more
wiley   +1 more source

Structure and Dynamics of the HIV-1 Envelope Protein on the Virion Envelope. [PDF]

J Am Chem Soc
Majumder A, Dutta M, Cherek L, Voth GA.
europepmc   +1 more source

British National Formulary Guidance on prescribing in pregnancy: A descriptive cross‐sectional study

British Journal of Clinical Pharmacology, EarlyView.
Aim To assess how well pregnancy‐specific guidance within the British National Formulary supports healthcare professionals to facilitate safe and effective medication use. Methods We performed a manifest content analysis of the text of all pregnancy sections within British National Formulary drug monographs, with inductive and iterative coding.
Hannah Johnson, Cleodie Swire, Lakshiv Dhingra, Toqa El‐Nahhas, Michelle Essiam, Salma Muse, Maria Tonkova, Nazmin Begum, Joan Morris, Emma Baker   +9 more
wiley   +1 more source

[Impact of HIV-1 genotypes and population mobility on HIV-1 transmission in Guangzhou: a molecular transmission network analysis]. [PDF]

Nan Fang Yi Ke Da Xue Xue Bao
Huang W, Yan H, Li S, Wu H, Cai Y, Han Z, Tang S.   +6 more
europepmc   +1 more source

Atazanavir/Ritonavir-Associated Erythema Multiforme in an HIV-1-Positive Patient. [PDF]

Cureus
Singh RK.
europepmc   +1 more source